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• W2168470557 abstract "Purpose/Objective(s)Current Radiation Therapy (RT) planning for lung stereotactic body radiation therapy (SBRT) is based on dose volume histogram such as V20 and mean lung dose to avoid radiation induced lung injury based on the assumption that the pulmonary function is the same everywhere inside lung. However, the actual lung function is indeed region specific and it can be incorporated into RT planning for functional lung avoidance. We have previously developed ventilation imaging methods coupling either free breathing 4DCT or breath hold MRI with deformable image registration. In this study, we compare the ventilation measurements from two imaging modalities on a regional basis.Materials/MethodsThe max inhale phase and the max exhale phase were extracted from the free breathing 4DCT for one lung cancer patient planned with SBRT with 55 Gy to PTVs in the right and the left lung respectively. A MRI scan pair near the end of inhale and near the end of exhale with breath hold were also acquired before RT. B-spline based vesselness preserving image registration algorithm was applied to register the breath hold MRI pair and the extreme phase pair from 4DCT separately for the calculation of regional ventilation measured as the Jacobian determinant of the displacement field from the registration result. The ventilation maps from the both breath hold MRI and free breathing 4DCT were then mapped to the planning CT using the same algorithm tuned for MRI-CT and CT-CT registrations. The ratio of the ventilation values from two methods were compared in a regional basis.ResultsThe ratio between the ventilation measured from free breathing 4DCT and the breath hold MRI has the mean value of 1.61. 91.8% of the lung voxels have the ratio large than 1 indicating the breath hold may recruit different breathing unit of the lung for breathing between the free breathing and the breath hold procedure. A strong heterogeneity was found inside the lung from the ratio map which also suggests different breathing pattern between the two procedures.ConclusionWe compared free breathing 4DCT based and static breath-hold MRI based lung imaging to evaluate regional ventilation for RT planning which may take the underlying lung function into account. Further investigation is needed to study which method is more sensitive and robust for regional lung ventilation measurement. Purpose/Objective(s)Current Radiation Therapy (RT) planning for lung stereotactic body radiation therapy (SBRT) is based on dose volume histogram such as V20 and mean lung dose to avoid radiation induced lung injury based on the assumption that the pulmonary function is the same everywhere inside lung. However, the actual lung function is indeed region specific and it can be incorporated into RT planning for functional lung avoidance. We have previously developed ventilation imaging methods coupling either free breathing 4DCT or breath hold MRI with deformable image registration. In this study, we compare the ventilation measurements from two imaging modalities on a regional basis. Current Radiation Therapy (RT) planning for lung stereotactic body radiation therapy (SBRT) is based on dose volume histogram such as V20 and mean lung dose to avoid radiation induced lung injury based on the assumption that the pulmonary function is the same everywhere inside lung. However, the actual lung function is indeed region specific and it can be incorporated into RT planning for functional lung avoidance. We have previously developed ventilation imaging methods coupling either free breathing 4DCT or breath hold MRI with deformable image registration. In this study, we compare the ventilation measurements from two imaging modalities on a regional basis. Materials/MethodsThe max inhale phase and the max exhale phase were extracted from the free breathing 4DCT for one lung cancer patient planned with SBRT with 55 Gy to PTVs in the right and the left lung respectively. A MRI scan pair near the end of inhale and near the end of exhale with breath hold were also acquired before RT. B-spline based vesselness preserving image registration algorithm was applied to register the breath hold MRI pair and the extreme phase pair from 4DCT separately for the calculation of regional ventilation measured as the Jacobian determinant of the displacement field from the registration result. The ventilation maps from the both breath hold MRI and free breathing 4DCT were then mapped to the planning CT using the same algorithm tuned for MRI-CT and CT-CT registrations. The ratio of the ventilation values from two methods were compared in a regional basis. The max inhale phase and the max exhale phase were extracted from the free breathing 4DCT for one lung cancer patient planned with SBRT with 55 Gy to PTVs in the right and the left lung respectively. A MRI scan pair near the end of inhale and near the end of exhale with breath hold were also acquired before RT. B-spline based vesselness preserving image registration algorithm was applied to register the breath hold MRI pair and the extreme phase pair from 4DCT separately for the calculation of regional ventilation measured as the Jacobian determinant of the displacement field from the registration result. The ventilation maps from the both breath hold MRI and free breathing 4DCT were then mapped to the planning CT using the same algorithm tuned for MRI-CT and CT-CT registrations. The ratio of the ventilation values from two methods were compared in a regional basis. ResultsThe ratio between the ventilation measured from free breathing 4DCT and the breath hold MRI has the mean value of 1.61. 91.8% of the lung voxels have the ratio large than 1 indicating the breath hold may recruit different breathing unit of the lung for breathing between the free breathing and the breath hold procedure. A strong heterogeneity was found inside the lung from the ratio map which also suggests different breathing pattern between the two procedures. The ratio between the ventilation measured from free breathing 4DCT and the breath hold MRI has the mean value of 1.61. 91.8% of the lung voxels have the ratio large than 1 indicating the breath hold may recruit different breathing unit of the lung for breathing between the free breathing and the breath hold procedure. A strong heterogeneity was found inside the lung from the ratio map which also suggests different breathing pattern between the two procedures. ConclusionWe compared free breathing 4DCT based and static breath-hold MRI based lung imaging to evaluate regional ventilation for RT planning which may take the underlying lung function into account. Further investigation is needed to study which method is more sensitive and robust for regional lung ventilation measurement. We compared free breathing 4DCT based and static breath-hold MRI based lung imaging to evaluate regional ventilation for RT planning which may take the underlying lung function into account. Further investigation is needed to study which method is more sensitive and robust for regional lung ventilation measurement." @default.
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• W2168470557 date "2012-11-01" @default.
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• W2168470557 title "Ventilation Imaging for Lung Radiation Therapy Planning: Free Breathing 4DCT Versus Breath-hold MRI" @default.
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