FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168476645> ?p ?o ?g. }

• W2168476645 endingPage "53" @default.
• W2168476645 startingPage "53" @default.
• W2168476645 abstract "A novel application of fluorescence in situ hybridization (FISH) to isolated nuclei is described. The method detects gene amplification and chromosome aneuploidy in extracted nuclei from paraffin-embedded tissue of human cancer with greater sensitivity and specificity than existing FISH methods. In this study, the method is applied to signal detection of the HER-2/neu (c-erbB-2) gene, whose amplification is one of the most common genetic alterations associated with human breast cancer. Nuclei were extracted and isolated from formalin fixed, paraffin embedded tissue of 43 different carcinomas (breast, ovary, endometrium, gastrointestinal stromal tumor and malignant mesothelioma). FISH was performed both on sections and extracted nuclei of each tissue using chromosome enumeration probes (CEP) for the centromeric regions of chromosomes 8 and 17, and a locus specific identifier (LSI) for the HER-2/neu oncogene. Differences between ploidy calculated in sections and extracted nuclei were seen in 3 breast carcinomas and 1 gastrointestinal stromal tumor (GIST). Furthermore, 1 breast cancer, previously considered to be borderline for HER-2/neu gene amplification turned out to be clearly amplified. Nuclei extraction and isolation bypass all the problems related to signal interpretation in tissue sections, and the adoption of this new technique, which improves the signal quality in several neoplastic samples, is suggested." @default.
• W2168476645 created "2016-06-24" @default.
• W2168476645 creator A5010415164 @default.
• W2168476645 creator A5014694544 @default.
• W2168476645 creator A5050184064 @default.
• W2168476645 creator A5069612164 @default.
• W2168476645 creator A5075181427 @default.
• W2168476645 creator A5081861285 @default.
• W2168476645 date "2009-06-29" @default.
• W2168476645 modified "2023-10-01" @default.
• W2168476645 title "High-level detection of gene amplification and chromosome aneuploidy in extracted nuclei from paraffin-embedded tissue of human cancer using FISH: a new approach for retrospective studies" @default.
• W2168476645 cites W1583886175 @default.
• W2168476645 cites W1867197625 @default.
• W2168476645 cites W2021641556 @default.
• W2168476645 cites W2022895967 @default.
• W2168476645 cites W2025094110 @default.
• W2168476645 cites W2025211708 @default.
• W2168476645 cites W2026780912 @default.
• W2168476645 cites W2032263472 @default.
• W2168476645 cites W2045956393 @default.
• W2168476645 cites W2048337491 @default.
• W2168476645 cites W2076614293 @default.
• W2168476645 cites W2084234026 @default.
• W2168476645 cites W2100716241 @default.
• W2168476645 cites W2119046955 @default.
• W2168476645 cites W2133407636 @default.
• W2168476645 cites W2139713460 @default.
• W2168476645 cites W2144970247 @default.
• W2168476645 cites W2264426482 @default.
• W2168476645 cites W2320066500 @default.
• W2168476645 cites W2346648541 @default.
• W2168476645 cites W2428545643 @default.
• W2168476645 cites W287693631 @default.
• W2168476645 cites W53085452 @default.
• W2168476645 cites W947041447 @default.
• W2168476645 doi "https://doi.org/10.4081/927" @default.
• W2168476645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15823795" @default.
• W2168476645 hasPublicationYear "2009" @default.
• W2168476645 type Work @default.
• W2168476645 sameAs 2168476645 @default.
• W2168476645 citedByCount "7" @default.
• W2168476645 countsByYear W21684766452014 @default.
• W2168476645 countsByYear W21684766452016 @default.
• W2168476645 countsByYear W21684766452023 @default.
• W2168476645 crossrefType "journal-article" @default.
• W2168476645 hasAuthorship W2168476645A5010415164 @default.
• W2168476645 hasAuthorship W2168476645A5014694544 @default.
• W2168476645 hasAuthorship W2168476645A5050184064 @default.
• W2168476645 hasAuthorship W2168476645A5069612164 @default.
• W2168476645 hasAuthorship W2168476645A5075181427 @default.
• W2168476645 hasAuthorship W2168476645A5081861285 @default.
• W2168476645 hasBestOaLocation W21684766451 @default.
• W2168476645 hasConcept C104317684 @default.
• W2168476645 hasConcept C121608353 @default.
• W2168476645 hasConcept C142724271 @default.
• W2168476645 hasConcept C153911025 @default.
• W2168476645 hasConcept C167752854 @default.
• W2168476645 hasConcept C16930146 @default.
• W2168476645 hasConcept C2777542201 @default.
• W2168476645 hasConcept C2779672484 @default.
• W2168476645 hasConcept C30481170 @default.
• W2168476645 hasConcept C502942594 @default.
• W2168476645 hasConcept C530470458 @default.
• W2168476645 hasConcept C54355233 @default.
• W2168476645 hasConcept C71924100 @default.
• W2168476645 hasConcept C7602840 @default.
• W2168476645 hasConcept C86803240 @default.
• W2168476645 hasConceptScore W2168476645C104317684 @default.
• W2168476645 hasConceptScore W2168476645C121608353 @default.
• W2168476645 hasConceptScore W2168476645C142724271 @default.
• W2168476645 hasConceptScore W2168476645C153911025 @default.
• W2168476645 hasConceptScore W2168476645C167752854 @default.
• W2168476645 hasConceptScore W2168476645C16930146 @default.
• W2168476645 hasConceptScore W2168476645C2777542201 @default.
• W2168476645 hasConceptScore W2168476645C2779672484 @default.
• W2168476645 hasConceptScore W2168476645C30481170 @default.
• W2168476645 hasConceptScore W2168476645C502942594 @default.
• W2168476645 hasConceptScore W2168476645C530470458 @default.
• W2168476645 hasConceptScore W2168476645C54355233 @default.
• W2168476645 hasConceptScore W2168476645C71924100 @default.
• W2168476645 hasConceptScore W2168476645C7602840 @default.
• W2168476645 hasConceptScore W2168476645C86803240 @default.
• W2168476645 hasIssue "1" @default.
• W2168476645 hasLocation W21684766451 @default.
• W2168476645 hasLocation W21684766452 @default.
• W2168476645 hasLocation W21684766453 @default.
• W2168476645 hasOpenAccess W2168476645 @default.
• W2168476645 hasPrimaryLocation W21684766451 @default.
• W2168476645 hasRelatedWork W1967762412 @default.
• W2168476645 hasRelatedWork W2040635823 @default.
• W2168476645 hasRelatedWork W2060672055 @default.
• W2168476645 hasRelatedWork W2104046523 @default.
• W2168476645 hasRelatedWork W2348939472 @default.
• W2168476645 hasRelatedWork W2349295438 @default.
• W2168476645 hasRelatedWork W2375924121 @default.
• W2168476645 hasRelatedWork W2383037135 @default.
• W2168476645 hasRelatedWork W2401106974 @default.
• W2168476645 hasRelatedWork W2411621912 @default.

• next