FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168495854> ?p ?o ?g. }

• W2168495854 endingPage "6272" @default.
• W2168495854 startingPage "6262" @default.
• W2168495854 abstract "ABSTRACT Our views of the genes that drive phenotypes have generally been built up one locus or operon at a time. However, a given phenotype, such as virulence, is a multilocus phenomenon. To gain a more comprehensive view of the genes and interactions underlying a phenotype, we propose an approach that incorporates information from comparative genomics and network biology and illustrate it by examining the virulence phenotype of Vibrio cholerae O1 El Tor N16961. We assessed the associations among the virulence-associated proteins from Vibrio cholerae and all the other proteins from this bacterium using a functional-association network map. In the context of this map, we were able to identify 262 proteins that are functionally linked to the virulence-associated genes more closely than is typical of the proteins in this strain and 240 proteins that are functionally linked to the virulence-associated proteins with a confidence score greater than 0.9. The roles of these genes were investigated using functional information from online data sources, comparative genomics, and the relationships shown by the protein association map. We also incorporated core proteome data from the family Vibrionaceae ; 35% of the virulence-associated proteins have orthologs among the 1,822 orthologous groups of proteins in the core proteome, indicating that they may be dual-role virulence genes or encode functions that have value outside the human host. This approach is a valuable tool in searching for novel functional associations and in investigating the relationship between genotype and phenotype." @default.
• W2168495854 created "2016-06-24" @default.
• W2168495854 creator A5005297420 @default.
• W2168495854 creator A5049012343 @default.
• W2168495854 creator A5090573566 @default.
• W2168495854 date "2009-10-15" @default.
• W2168495854 modified "2023-09-26" @default.
• W2168495854 title "A Comparative Genomics, Network-Based Approach to Understanding Virulence in Vibrio cholerae" @default.
• W2168495854 cites W1506950787 @default.
• W2168495854 cites W1637936532 @default.
• W2168495854 cites W1850339904 @default.
• W2168495854 cites W1967818960 @default.
• W2168495854 cites W1972067810 @default.
• W2168495854 cites W1972122284 @default.
• W2168495854 cites W1976511855 @default.
• W2168495854 cites W1984445465 @default.
• W2168495854 cites W1986020144 @default.
• W2168495854 cites W1996826903 @default.
• W2168495854 cites W2001773648 @default.
• W2168495854 cites W2008856488 @default.
• W2168495854 cites W2009491450 @default.
• W2168495854 cites W2013457323 @default.
• W2168495854 cites W2014834088 @default.
• W2168495854 cites W2021907449 @default.
• W2168495854 cites W2022633023 @default.
• W2168495854 cites W2028165851 @default.
• W2168495854 cites W2028857164 @default.
• W2168495854 cites W2029112298 @default.
• W2168495854 cites W2052451249 @default.
• W2168495854 cites W2060740333 @default.
• W2168495854 cites W2064441783 @default.
• W2168495854 cites W2065329772 @default.
• W2168495854 cites W2069281673 @default.
• W2168495854 cites W2073112147 @default.
• W2168495854 cites W2076724084 @default.
• W2168495854 cites W2084267822 @default.
• W2168495854 cites W2084884574 @default.
• W2168495854 cites W2096803923 @default.
• W2168495854 cites W2097795961 @default.
• W2168495854 cites W2098673485 @default.
• W2168495854 cites W2100990314 @default.
• W2168495854 cites W2107109782 @default.
• W2168495854 cites W2107943090 @default.
• W2168495854 cites W2113613985 @default.
• W2168495854 cites W2121742742 @default.
• W2168495854 cites W2124926885 @default.
• W2168495854 cites W2130790725 @default.
• W2168495854 cites W2132784310 @default.
• W2168495854 cites W2135401299 @default.
• W2168495854 cites W2135580745 @default.
• W2168495854 cites W2139275024 @default.
• W2168495854 cites W2139969153 @default.
• W2168495854 cites W2140930857 @default.
• W2168495854 cites W2141251126 @default.
• W2168495854 cites W2141626941 @default.
• W2168495854 cites W2142637309 @default.
• W2168495854 cites W2142736798 @default.
• W2168495854 cites W2144656637 @default.
• W2168495854 cites W2146429915 @default.
• W2168495854 cites W2147185759 @default.
• W2168495854 cites W2148472871 @default.
• W2168495854 cites W2148915230 @default.
• W2168495854 cites W2150318080 @default.
• W2168495854 cites W2152285853 @default.
• W2168495854 cites W2152856654 @default.
• W2168495854 cites W2153173493 @default.
• W2168495854 cites W2154496121 @default.
• W2168495854 cites W2155606054 @default.
• W2168495854 cites W2155917985 @default.
• W2168495854 cites W2157267947 @default.
• W2168495854 cites W2159410139 @default.
• W2168495854 cites W2159675211 @default.
• W2168495854 cites W2161834542 @default.
• W2168495854 cites W2162376398 @default.
• W2168495854 cites W2162953780 @default.
• W2168495854 cites W2164485511 @default.
• W2168495854 cites W2166705366 @default.
• W2168495854 cites W2167450753 @default.
• W2168495854 cites W2169420537 @default.
• W2168495854 cites W2170333156 @default.
• W2168495854 cites W2171030481 @default.
• W2168495854 cites W4211040199 @default.
• W2168495854 cites W4248664566 @default.
• W2168495854 doi "https://doi.org/10.1128/jb.00475-09" @default.
• W2168495854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2753031" @default.
• W2168495854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19666715" @default.
• W2168495854 hasPublicationYear "2009" @default.
• W2168495854 type Work @default.
• W2168495854 sameAs 2168495854 @default.
• W2168495854 citedByCount "10" @default.
• W2168495854 countsByYear W21684958542012 @default.
• W2168495854 countsByYear W21684958542014 @default.
• W2168495854 countsByYear W21684958542019 @default.
• W2168495854 countsByYear W21684958542020 @default.
• W2168495854 countsByYear W21684958542021 @default.
• W2168495854 crossrefType "journal-article" @default.
• W2168495854 hasAuthorship W2168495854A5005297420 @default.
• W2168495854 hasAuthorship W2168495854A5049012343 @default.

• next