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- W2168519169 abstract "ABSTRACT Isoleucine deprivation of cellular monolayers prior to infection has been reported to result in partial complementation of a herpes simplex virus type 1 (HSV-1) ICP0 null (ICP0 − ) mutant. We now report that glutamine deprivation alone is able to enhance the plating efficiency of an ICP0 − virus and that isoleucine deprivation has little or no effect. Because a low glutamine level is associated with stress and because stress is known to induce reactivation, low levels of glutamine may be relevant to the reactivation of HSV-1 from latency. Additionally, we demonstrate that arginine and methionine deprivation result in partial complementation of the ICP0 − virus." @default.
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- W2168519169 date "2008-11-15" @default.
- W2168519169 modified "2023-09-27" @default.
- W2168519169 title "Glutamine Deprivation Causes Enhanced Plating Efficiency of a Herpes Simplex Virus Type 1 ICP0-Null Mutant" @default.
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- W2168519169 doi "https://doi.org/10.1128/jvi.01086-08" @default.
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