Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168548026> ?p ?o ?g. }
- W2168548026 endingPage "1175" @default.
- W2168548026 startingPage "1163" @default.
- W2168548026 abstract "A higher incidence of coronary artery disease is associated with a lower level of HDL-cholesterol. We searched for genetic loci influencing HDL-cholesterol in F2 mice from a cross between MRL/MpJ and SM/J mice. Quantitative trait loci (QTL) mapping revealed one significant HDL QTL (Apoa2 locus), four suggestive QTL on chromosomes 10, 11, 13, and 18 and four additional QTL on chromosomes 1 proximal, 3, 4, and 7 after adjusting HDL for the strong Apoa2 locus. A novel nonsynonymous polymorphism supports Lipg as the QTL gene for the chromosome 18 QTL, and a difference in Abca1 expression in liver tissue supports it as the QTL gene for the chromosome 4 QTL. Using weighted gene co-expression network analysis, we identified a module that after adjustment for Apoa2, correlated with HDL, was genetically determined by a QTL on chromosome 11, and overlapped with the HDL QTL. A combination of bioinformatics tools and systems genetics helped identify several candidate genes for both the chromosome 11 HDL and module QTL based on differential expression between the parental strains, cis regulation of expression, and causality modeling. We conclude that integrating systems genetics to a more-traditional genetics approach improves the power of complex trait gene identification." @default.
- W2168548026 created "2016-06-24" @default.
- W2168548026 creator A5005303346 @default.
- W2168548026 creator A5006860298 @default.
- W2168548026 creator A5012821611 @default.
- W2168548026 creator A5027921557 @default.
- W2168548026 creator A5033268270 @default.
- W2168548026 creator A5035352807 @default.
- W2168548026 creator A5057637591 @default.
- W2168548026 date "2012-06-01" @default.
- W2168548026 modified "2023-09-28" @default.
- W2168548026 title "Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ × SM/J intercross" @default.
- W2168548026 cites W1685382538 @default.
- W2168548026 cites W1929591387 @default.
- W2168548026 cites W1964256485 @default.
- W2168548026 cites W1964305071 @default.
- W2168548026 cites W1966327575 @default.
- W2168548026 cites W1966610596 @default.
- W2168548026 cites W1969219820 @default.
- W2168548026 cites W1974399491 @default.
- W2168548026 cites W1978684704 @default.
- W2168548026 cites W1982359478 @default.
- W2168548026 cites W1982810064 @default.
- W2168548026 cites W1989249306 @default.
- W2168548026 cites W1992118324 @default.
- W2168548026 cites W1995716751 @default.
- W2168548026 cites W1997894191 @default.
- W2168548026 cites W1998616212 @default.
- W2168548026 cites W2007991295 @default.
- W2168548026 cites W2017599655 @default.
- W2168548026 cites W2017685968 @default.
- W2168548026 cites W2020372413 @default.
- W2168548026 cites W2020901813 @default.
- W2168548026 cites W2023723430 @default.
- W2168548026 cites W2038892866 @default.
- W2168548026 cites W2048481833 @default.
- W2168548026 cites W2048760408 @default.
- W2168548026 cites W2064588547 @default.
- W2168548026 cites W2066288680 @default.
- W2168548026 cites W2083315579 @default.
- W2168548026 cites W2090107501 @default.
- W2168548026 cites W2104319042 @default.
- W2168548026 cites W2105282353 @default.
- W2168548026 cites W2115801316 @default.
- W2168548026 cites W2116053845 @default.
- W2168548026 cites W2116151546 @default.
- W2168548026 cites W2116995727 @default.
- W2168548026 cites W2119395863 @default.
- W2168548026 cites W2120865735 @default.
- W2168548026 cites W2135827569 @default.
- W2168548026 cites W2141674000 @default.
- W2168548026 cites W2144001239 @default.
- W2168548026 cites W2144473676 @default.
- W2168548026 cites W2145493621 @default.
- W2168548026 cites W2145545235 @default.
- W2168548026 cites W2150188159 @default.
- W2168548026 cites W2151488747 @default.
- W2168548026 cites W2154829503 @default.
- W2168548026 cites W2159612310 @default.
- W2168548026 cites W2164004777 @default.
- W2168548026 cites W2166653960 @default.
- W2168548026 cites W2167612600 @default.
- W2168548026 cites W2187695897 @default.
- W2168548026 doi "https://doi.org/10.1194/jlr.m025833" @default.
- W2168548026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3351823" @default.
- W2168548026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22498810" @default.
- W2168548026 hasPublicationYear "2012" @default.
- W2168548026 type Work @default.
- W2168548026 sameAs 2168548026 @default.
- W2168548026 citedByCount "12" @default.
- W2168548026 countsByYear W21685480262013 @default.
- W2168548026 countsByYear W21685480262014 @default.
- W2168548026 countsByYear W21685480262017 @default.
- W2168548026 countsByYear W21685480262018 @default.
- W2168548026 countsByYear W21685480262021 @default.
- W2168548026 countsByYear W21685480262022 @default.
- W2168548026 countsByYear W21685480262023 @default.
- W2168548026 crossrefType "journal-article" @default.
- W2168548026 hasAuthorship W2168548026A5005303346 @default.
- W2168548026 hasAuthorship W2168548026A5006860298 @default.
- W2168548026 hasAuthorship W2168548026A5012821611 @default.
- W2168548026 hasAuthorship W2168548026A5027921557 @default.
- W2168548026 hasAuthorship W2168548026A5033268270 @default.
- W2168548026 hasAuthorship W2168548026A5035352807 @default.
- W2168548026 hasAuthorship W2168548026A5057637591 @default.
- W2168548026 hasBestOaLocation W21685480261 @default.
- W2168548026 hasConcept C104317684 @default.
- W2168548026 hasConcept C122735190 @default.
- W2168548026 hasConcept C134925867 @default.
- W2168548026 hasConcept C135763542 @default.
- W2168548026 hasConcept C153209595 @default.
- W2168548026 hasConcept C168393362 @default.
- W2168548026 hasConcept C21249469 @default.
- W2168548026 hasConcept C30481170 @default.
- W2168548026 hasConcept C54355233 @default.
- W2168548026 hasConcept C69991583 @default.
- W2168548026 hasConcept C81941488 @default.
- W2168548026 hasConcept C84597430 @default.