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• W2168557435 abstract "ABSTRACT Autoinducer 2 (AI-2) is required for the growth of Aggregatibacter ( Actinobacillus ) actinomycetemcomitans in culture under conditions of iron limitation. However, in vivo this organism thrives in a complex multispecies biofilm that forms in the human oral cavity. In this report, we show that adherent growth of A. actinomycetemcomitans on a saliva-coated surface, but not planktonic growth under iron-replete conditions, is defective in a LuxS-deficient background. Biofilm growth of the luxS mutant exhibited lower total biomass and lower biofilm depth than those for the wild-type strain. Normal biofilm growth of the luxS mutant was restored genetically by introduction of a functional copy of luxS and biochemically by addition of partially purified AI-2. Furthermore, introduction of S -adenosylhomocysteine hydrolase, which restores the metabolism of S -adenosylmethionine in the absence of LuxS, into A. actinomycetemcomitans did not complement the luxS mutation unless AI-2 was added in trans . This suggests that AI-2 itself is required for biofilm growth by A. actinomycetemcomitans . A biofilm growth deficiency similar to that of the LuxS-deficient strain was also observed when a gene encoding the AI-2-interacting protein RbsB or LsrB was inactivated. Biofilm formation by A. actinomycetemcomitans was virtually eliminated upon inactivation of both rbsB and lsrB . In addition, biofilm growth by wild-type A. actinomycetemcomitans was reduced in the presence of ribose, which competes with AI-2 for binding to RbsB. These results suggest that RbsB and LsrB function as AI-2 receptors in A. actinomycetemcomitans and that the development of A. actinomycetemcomitans biofilms requires AI-2." @default.
• W2168557435 created "2016-06-24" @default.
• W2168557435 creator A5006760859 @default.
• W2168557435 creator A5008946134 @default.
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• W2168557435 date "2007-09-01" @default.
• W2168557435 modified "2023-09-27" @default.
• W2168557435 title "Autoinducer 2 Is Required for Biofilm Growth of <i>Aggregatibacter</i> ( <i>Actinobacillus</i> ) <i>actinomycetemcomitans</i>" @default.
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• W2168557435 doi "https://doi.org/10.1128/iai.00402-07" @default.
• W2168557435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1951166" @default.
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