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• W2168558768 abstract "Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders. The progressive remodeling of brain microvessels due to arterial hypertension or other vascular risk factors causes subtle, but constant cognitive decline through to manifest dementia and substantially increases the risk for stroke. Preliminary evidence suggests the contribution of the immune system to disease initiation and progression, but a more detailed understanding is impaired by the unavailability of appropriate animal models. Here, we introduce the spontaneously hypertensive rat (SHR) as a model for early onset cSVD and unveiled substantial immune changes in conjunction with brain abnormalities that resemble clinical findings.In contrast to age-matched normotensive Wistar Kyoto (WKY) rats, male SHR exhibited non-spatial memory deficits. Magnetic resonance imaging showed brain atrophy and a reduction of white matter volumes in SHR. Histological analyses confirmed white matter demyelination and unveiled a circumscribed blood brain barrier dysfunction in conjunction with micro- and macrogliosis in deep cortical regions. Flow cytometry and histological analyses further revealed substantial disparities in cerebral CD45high leukocyte counts and distribution patterns between SHR and WKY. SHR showed lower counts of T cells in the choroid plexus and meningeal spaces as well as decreased interleukin-10 levels in the cerebrospinal fluid. On the other hand, both T and NK cells were significantly augmented in the SHR brain microvasculature.Our results indicate that SHR share behavioral and neuropathological characteristics with human cSVD patients and further undergird the relevance of immune responses for the initiation and progression of cSVD." @default.
• W2168558768 created "2016-06-24" @default.
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• W2168558768 date "2014-12-01" @default.
• W2168558768 modified "2023-10-12" @default.
• W2168558768 title "Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease" @default.
• W2168558768 cites W1504066791 @default.
• W2168558768 cites W1534761457 @default.
• W2168558768 cites W1552103637 @default.
• W2168558768 cites W1578359906 @default.
• W2168558768 cites W1600560134 @default.
• W2168558768 cites W1831914306 @default.
• W2168558768 cites W1910162587 @default.
• W2168558768 cites W1964580878 @default.
• W2168558768 cites W1969700660 @default.
• W2168558768 cites W1972140032 @default.
• W2168558768 cites W1972545796 @default.
• W2168558768 cites W1986782185 @default.
• W2168558768 cites W1995866677 @default.
• W2168558768 cites W2002430747 @default.
• W2168558768 cites W2004349171 @default.
• W2168558768 cites W2005754674 @default.
• W2168558768 cites W2005980822 @default.
• W2168558768 cites W2006672829 @default.
• W2168558768 cites W2007859835 @default.
• W2168558768 cites W2010433426 @default.
• W2168558768 cites W2013636732 @default.
• W2168558768 cites W2016418670 @default.
• W2168558768 cites W2022765352 @default.
• W2168558768 cites W2022857700 @default.
• W2168558768 cites W2032919519 @default.
• W2168558768 cites W2035439084 @default.
• W2168558768 cites W2035809865 @default.
• W2168558768 cites W2041202229 @default.
• W2168558768 cites W2042427055 @default.
• W2168558768 cites W2043880713 @default.
• W2168558768 cites W2061353398 @default.
• W2168558768 cites W2061781158 @default.
• W2168558768 cites W2062163100 @default.
• W2168558768 cites W2072441360 @default.
• W2168558768 cites W2077500496 @default.
• W2168558768 cites W2082231545 @default.
• W2168558768 cites W2088733850 @default.
• W2168558768 cites W2090829353 @default.
• W2168558768 cites W2092650586 @default.
• W2168558768 cites W2099341695 @default.
• W2168558768 cites W2102780439 @default.
• W2168558768 cites W2103597959 @default.
• W2168558768 cites W2104901197 @default.
• W2168558768 cites W2108329377 @default.
• W2168558768 cites W2109011905 @default.
• W2168558768 cites W2109598200 @default.
• W2168558768 cites W2110729320 @default.
• W2168558768 cites W2111009586 @default.
• W2168558768 cites W2111800376 @default.
• W2168558768 cites W2112118655 @default.
• W2168558768 cites W2115207239 @default.
• W2168558768 cites W2119313270 @default.
• W2168558768 cites W2120437689 @default.
• W2168558768 cites W2124054487 @default.
• W2168558768 cites W2130766313 @default.
• W2168558768 cites W2132421444 @default.
• W2168558768 cites W2133402519 @default.
• W2168558768 cites W2135158617 @default.
• W2168558768 cites W2136295271 @default.
• W2168558768 cites W2136671298 @default.
• W2168558768 cites W2138465150 @default.
• W2168558768 cites W2140621953 @default.
• W2168558768 cites W2143140966 @default.
• W2168558768 cites W2145034992 @default.
• W2168558768 cites W2148856395 @default.
• W2168558768 cites W2150664247 @default.
• W2168558768 cites W2151372937 @default.
• W2168558768 cites W2152063570 @default.
• W2168558768 cites W2152409603 @default.
• W2168558768 cites W2159753138 @default.
• W2168558768 cites W2166469889 @default.
• W2168558768 cites W2168364487 @default.
• W2168558768 cites W2312943022 @default.
• W2168558768 cites W2527609605 @default.
• W2168558768 cites W2928618355 @default.
• W2168558768 cites W4249741519 @default.
• W2168558768 cites W59296430 @default.
• W2168558768 doi "https://doi.org/10.1186/s40478-014-0169-8" @default.
• W2168558768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4279586" @default.
• W2168558768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25519173" @default.
• W2168558768 hasPublicationYear "2014" @default.
• W2168558768 type Work @default.

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