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• W2168561176 abstract "Induction of a specific transcriptional program by external signaling inputs is a crucial aspect of intracellular network functioning. The theoretical concept of coexisting attractors representing particular genetic programs is reasonably adapted to experimental observations of “genome-wide” expression profiles or phenotypes. Attractors can be associated either with developmental outcomes such as differentiation into specific types of cells, or maintenance of cell functioning such as proliferation or apoptosis. Here we review a mechanism known as speed-dependent cellular decision making (SdCDM) in a small epigenetic switch and generalize the concept to high-dimensional space. We demonstrate that high-dimensional network clustering capacity is dependent on the level of intrinsic noise and the speed at which external signals operate on the transcriptional landscape." @default.
• W2168561176 created "2016-06-24" @default.
• W2168561176 creator A5029926969 @default.
• W2168561176 creator A5042447350 @default.
• W2168561176 date "2012-07-16" @default.
• W2168561176 modified "2023-10-16" @default.
• W2168561176 title "Interplay between Path and Speed in Decision Making by High-Dimensional Stochastic Gene Regulatory Networks" @default.
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• W2168561176 doi "https://doi.org/10.1371/journal.pone.0040085" @default.
• W2168561176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398018" @default.
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• W2168561176 hasPublicationYear "2012" @default.
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