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- W2168591440 abstract "Macrophages are on the front line of host defense. They possess an array of germline-encoded pattern recognition receptors/sensors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and which activate downstream effectors/pathways to help mediate innate immune responses and host defense. Innate immune responses include the rapid induction of transcriptional networks that trigger the production of cytokines, chemokines, and cytotoxic molecules; the mobilization of cells including neutrophils and other leukocytes; the engulfment of pathogens by phagocytosis and their delivery to lysosome for degradation; and the induction of autophagy. Autophagy is a catabolic process that normally maintains cellular homeostasis in a lysosome-dependent manner, but it also functions as a cytoprotective response that intersects with a variety of general stress-response pathways. This review focuses on the intimately linked molecular mechanisms that help govern the autophagic pathway and macrophage innate immune responses." @default.
- W2168591440 created "2016-06-24" @default.
- W2168591440 creator A5042208014 @default.
- W2168591440 creator A5057092922 @default.
- W2168591440 date "2014-01-01" @default.
- W2168591440 modified "2023-10-14" @default.
- W2168591440 title "Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection" @default.
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- W2168591440 doi "https://doi.org/10.1155/2014/825463" @default.
- W2168591440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4000662" @default.
- W2168591440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24818040" @default.
- W2168591440 hasPublicationYear "2014" @default.
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