Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168603560> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2168603560 abstract "The estimation of cancer risk in individuals is of great interest for research teams. The kin-cohort method is a method of choice for estimating hazards and penetrance of cancer, because of its capability to illustrate the correlation between genotype and phenotype. In the estimation of cancer penetrance, many models omit to take into account the fact that hazards are likely to increase, decrease, or remain constant with respect to age variations. In order to estimate cancer penetrance by rectifying the said drawback of the commonly used models , we utilized a modified piecewise exponential model using weibull distribution, i.e. a piecewise Weibull model. We considered mutations in BRCA1 and BRCA2 genes, which are related to ovarian and breast cancer. A set of data similar to true values was generated. We analyzed the data set using both piecewise exponential and piecewise Weibull models. Our results showed that the Weibull model was closer than the exponential model to the true values in terms of estimating the hazards and penetrance and a significant difference between two models was recognized. For the persons who are at risk of developing cancer, Due to the importance of the estimation of incidence probability, methods that can generate most accurate estimations are preferable. Therefore, we recommend the piecewise Weibull model as a proper model for the estimation of hazard and penetrance." @default.
- W2168603560 created "2016-06-24" @default.
- W2168603560 creator A5002832713 @default.
- W2168603560 creator A5010302940 @default.
- W2168603560 creator A5011734352 @default.
- W2168603560 creator A5020724137 @default.
- W2168603560 creator A5064762253 @default.
- W2168603560 date "2009-01-01" @default.
- W2168603560 modified "2023-09-27" @default.
- W2168603560 title "Kin-cohort Estimate of Penetrance with Piecewise Weibull Model" @default.
- W2168603560 cites W121553317 @default.
- W2168603560 cites W1984881803 @default.
- W2168603560 cites W1991289129 @default.
- W2168603560 cites W2000919738 @default.
- W2168603560 cites W2008132111 @default.
- W2168603560 cites W2050594811 @default.
- W2168603560 cites W2066176747 @default.
- W2168603560 cites W2074282020 @default.
- W2168603560 cites W2089895854 @default.
- W2168603560 cites W2105245946 @default.
- W2168603560 cites W2106624070 @default.
- W2168603560 cites W2131347613 @default.
- W2168603560 cites W2133225943 @default.
- W2168603560 cites W2300678989 @default.
- W2168603560 cites W2328105863 @default.
- W2168603560 cites W578685584 @default.
- W2168603560 hasPublicationYear "2009" @default.
- W2168603560 type Work @default.
- W2168603560 sameAs 2168603560 @default.
- W2168603560 citedByCount "1" @default.
- W2168603560 countsByYear W21686035602017 @default.
- W2168603560 crossrefType "journal-article" @default.
- W2168603560 hasAuthorship W2168603560A5002832713 @default.
- W2168603560 hasAuthorship W2168603560A5010302940 @default.
- W2168603560 hasAuthorship W2168603560A5011734352 @default.
- W2168603560 hasAuthorship W2168603560A5020724137 @default.
- W2168603560 hasAuthorship W2168603560A5064762253 @default.
- W2168603560 hasConcept C104317684 @default.
- W2168603560 hasConcept C105795698 @default.
- W2168603560 hasConcept C127413603 @default.
- W2168603560 hasConcept C127716648 @default.
- W2168603560 hasConcept C134306372 @default.
- W2168603560 hasConcept C149782125 @default.
- W2168603560 hasConcept C164660894 @default.
- W2168603560 hasConcept C173291955 @default.
- W2168603560 hasConcept C200544954 @default.
- W2168603560 hasConcept C201995342 @default.
- W2168603560 hasConcept C33923547 @default.
- W2168603560 hasConcept C50382708 @default.
- W2168603560 hasConcept C54355233 @default.
- W2168603560 hasConcept C86803240 @default.
- W2168603560 hasConcept C96250715 @default.
- W2168603560 hasConceptScore W2168603560C104317684 @default.
- W2168603560 hasConceptScore W2168603560C105795698 @default.
- W2168603560 hasConceptScore W2168603560C127413603 @default.
- W2168603560 hasConceptScore W2168603560C127716648 @default.
- W2168603560 hasConceptScore W2168603560C134306372 @default.
- W2168603560 hasConceptScore W2168603560C149782125 @default.
- W2168603560 hasConceptScore W2168603560C164660894 @default.
- W2168603560 hasConceptScore W2168603560C173291955 @default.
- W2168603560 hasConceptScore W2168603560C200544954 @default.
- W2168603560 hasConceptScore W2168603560C201995342 @default.
- W2168603560 hasConceptScore W2168603560C33923547 @default.
- W2168603560 hasConceptScore W2168603560C50382708 @default.
- W2168603560 hasConceptScore W2168603560C54355233 @default.
- W2168603560 hasConceptScore W2168603560C86803240 @default.
- W2168603560 hasConceptScore W2168603560C96250715 @default.
- W2168603560 hasLocation W21686035601 @default.
- W2168603560 hasOpenAccess W2168603560 @default.
- W2168603560 hasPrimaryLocation W21686035601 @default.
- W2168603560 hasRelatedWork W1486989601 @default.
- W2168603560 hasRelatedWork W1559784040 @default.
- W2168603560 hasRelatedWork W1965240747 @default.
- W2168603560 hasRelatedWork W1992628211 @default.
- W2168603560 hasRelatedWork W1994008317 @default.
- W2168603560 hasRelatedWork W2010992209 @default.
- W2168603560 hasRelatedWork W2013231105 @default.
- W2168603560 hasRelatedWork W2017980290 @default.
- W2168603560 hasRelatedWork W2031837314 @default.
- W2168603560 hasRelatedWork W2114465466 @default.
- W2168603560 hasRelatedWork W2164427615 @default.
- W2168603560 hasRelatedWork W2183690433 @default.
- W2168603560 hasRelatedWork W2187003570 @default.
- W2168603560 hasRelatedWork W2289697542 @default.
- W2168603560 hasRelatedWork W2587502511 @default.
- W2168603560 hasRelatedWork W2613326358 @default.
- W2168603560 hasRelatedWork W308794564 @default.
- W2168603560 hasRelatedWork W3182165306 @default.
- W2168603560 hasRelatedWork W786682533 @default.
- W2168603560 hasRelatedWork W2187068735 @default.
- W2168603560 isParatext "false" @default.
- W2168603560 isRetracted "false" @default.
- W2168603560 magId "2168603560" @default.
- W2168603560 workType "article" @default.