FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168646723> ?p ?o ?g. }

• W2168646723 abstract "The role of the enzyme 11beta-hydroxysteroid dehydrogenase (11betaHSD) in hypertension remains unknown even if it appears that the inappropriately decreased 11betaHSD activity might be involved in a process that leads to high blood pressure. The possible changes of 11betaHSD were therefore investigated in rats with spontaneous or salt-induced hypertension. The adult male rats of the following genotypes were used: spontaneously hypertensive rats (SHR), normotensive Wistar-Kyoto rats (WKY), Dahl salt-sensitive rats fed either a high-salt diet containing 8% NaCl (DS-HS) or low-salt diet containing 0.2% NaCl (DS-LS), and Dahl salt-resistant rats fed the same diets (DR-HS, DR-LS). 11betaHSD was investigated in colon, aorta, renal cortex, and renal medulla and was assessed as percentage conversion of [3H]corticosterone to [3H]11-dehydrocorticosterone in the presence of NAD or NADP. The results demonstrated that genotype exerts a significant effect on 11betaHSD. 11betaHSD activity was significantly increased in colon and renal medulla of SHR compared with WKY rats. No significant differences were observed in renal cortex and aorta. In Dahl rats kept on a low-salt diet, 11betaHSD activity was significantly higher in colon, renal medulla, and cortex of DS-LS than in DR-LS rats but no difference was observed in aorta. The differences disappeared in age-matched DS and DR rats fed the high-salt diet. Increased dietary sodium intake stimulated the activity of 11betaHSD in renal cortex and medulla of DR rats and decreased the activity in colon of DS rats. We conclude that the development of spontaneous and salt-induced hypertension is not associated with decreased activity of 11betaHSD. However, the results showed that salt intake is able to modulate the activity of 11betaHSD and that 11betaHSD in DS and DR rats responds to high dietary salt intake in a different manner." @default.
• W2168646723 created "2016-06-24" @default.
• W2168646723 creator A5002194455 @default.
• W2168646723 creator A5007876269 @default.
• W2168646723 creator A5024669533 @default.
• W2168646723 creator A5076947309 @default.
• W2168646723 date "2000-08-01" @default.
• W2168646723 modified "2023-10-05" @default.
• W2168646723 title "11 -hydroxysteroid dehydrogenase activity in spontaneously hypertensive and Dahl rats" @default.
• W2168646723 cites W136076975 @default.
• W2168646723 cites W1503719518 @default.
• W2168646723 cites W1615328259 @default.
• W2168646723 cites W1871395002 @default.
• W2168646723 cites W1915010123 @default.
• W2168646723 cites W1964064816 @default.
• W2168646723 cites W1964332980 @default.
• W2168646723 cites W1964969914 @default.
• W2168646723 cites W1988365995 @default.
• W2168646723 cites W1992423160 @default.
• W2168646723 cites W1994533492 @default.
• W2168646723 cites W2000002639 @default.
• W2168646723 cites W2003544947 @default.
• W2168646723 cites W2036827114 @default.
• W2168646723 cites W2037135200 @default.
• W2168646723 cites W2042413521 @default.
• W2168646723 cites W2046793114 @default.
• W2168646723 cites W2062498788 @default.
• W2168646723 cites W2066415402 @default.
• W2168646723 cites W2086759864 @default.
• W2168646723 cites W2112024548 @default.
• W2168646723 cites W2120791350 @default.
• W2168646723 cites W2124888129 @default.
• W2168646723 cites W2135213898 @default.
• W2168646723 cites W2148114970 @default.
• W2168646723 cites W2162743374 @default.
• W2168646723 cites W2163757009 @default.
• W2168646723 cites W2172187560 @default.
• W2168646723 cites W2175189370 @default.
• W2168646723 cites W2317989044 @default.
• W2168646723 cites W2320163584 @default.
• W2168646723 cites W2322373571 @default.
• W2168646723 cites W2414984129 @default.
• W2168646723 cites W4251411483 @default.
• W2168646723 cites W4251528531 @default.
• W2168646723 cites W4293247451 @default.
• W2168646723 cites W2039115196 @default.
• W2168646723 doi "https://doi.org/10.1016/s0895-7061(00)00257-0" @default.
• W2168646723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10950402" @default.
• W2168646723 hasPublicationYear "2000" @default.
• W2168646723 type Work @default.
• W2168646723 sameAs 2168646723 @default.
• W2168646723 citedByCount "9" @default.
• W2168646723 countsByYear W21686467232012 @default.
• W2168646723 countsByYear W21686467232015 @default.
• W2168646723 crossrefType "journal-article" @default.
• W2168646723 hasAuthorship W2168646723A5002194455 @default.
• W2168646723 hasAuthorship W2168646723A5007876269 @default.
• W2168646723 hasAuthorship W2168646723A5024669533 @default.
• W2168646723 hasAuthorship W2168646723A5076947309 @default.
• W2168646723 hasBestOaLocation W21686467231 @default.
• W2168646723 hasConcept C126322002 @default.
• W2168646723 hasConcept C134018914 @default.
• W2168646723 hasConcept C169760540 @default.
• W2168646723 hasConcept C17291353 @default.
• W2168646723 hasConcept C181199279 @default.
• W2168646723 hasConcept C185592680 @default.
• W2168646723 hasConcept C2777348757 @default.
• W2168646723 hasConcept C2778577996 @default.
• W2168646723 hasConcept C2779980429 @default.
• W2168646723 hasConcept C2780091579 @default.
• W2168646723 hasConcept C2780352252 @default.
• W2168646723 hasConcept C2780512574 @default.
• W2168646723 hasConcept C55493867 @default.
• W2168646723 hasConcept C71315377 @default.
• W2168646723 hasConcept C71924100 @default.
• W2168646723 hasConcept C75520062 @default.
• W2168646723 hasConcept C84393581 @default.
• W2168646723 hasConcept C86803240 @default.
• W2168646723 hasConceptScore W2168646723C126322002 @default.
• W2168646723 hasConceptScore W2168646723C134018914 @default.
• W2168646723 hasConceptScore W2168646723C169760540 @default.
• W2168646723 hasConceptScore W2168646723C17291353 @default.
• W2168646723 hasConceptScore W2168646723C181199279 @default.
• W2168646723 hasConceptScore W2168646723C185592680 @default.
• W2168646723 hasConceptScore W2168646723C2777348757 @default.
• W2168646723 hasConceptScore W2168646723C2778577996 @default.
• W2168646723 hasConceptScore W2168646723C2779980429 @default.
• W2168646723 hasConceptScore W2168646723C2780091579 @default.
• W2168646723 hasConceptScore W2168646723C2780352252 @default.
• W2168646723 hasConceptScore W2168646723C2780512574 @default.
• W2168646723 hasConceptScore W2168646723C55493867 @default.
• W2168646723 hasConceptScore W2168646723C71315377 @default.
• W2168646723 hasConceptScore W2168646723C71924100 @default.
• W2168646723 hasConceptScore W2168646723C75520062 @default.
• W2168646723 hasConceptScore W2168646723C84393581 @default.
• W2168646723 hasConceptScore W2168646723C86803240 @default.
• W2168646723 hasLocation W21686467231 @default.
• W2168646723 hasLocation W21686467232 @default.
• W2168646723 hasOpenAccess W2168646723 @default.
• W2168646723 hasPrimaryLocation W21686467231 @default.

• next