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- W2168647145 abstract "Sensory input from the temporomandibular joint (TMJ) to neurons in superficial laminae at the spinomedullary (Vc/C1–2) region is strongly influenced by estrogen status. This study determined if GABAergic mechanisms play a role in estrogen modulation of TMJ nociceptive processing in ovariectomized female rats treated with high- (HE) or low-dose (LE) estradiol (E2) for 2 days. Superficial laminae neurons were activated by ATP (1 mM) injections into the joint space. The selective GABAA receptor antagonist, bicuculline methiodide (BMI, 5 or 50 μM, 30 μl), applied at the site of recording greatly enhanced the magnitude and duration of ATP-evoked responses in LE rats, but not in units from HE rats. The convergent cutaneous receptive field (RF) area of TMJ neurons was enlarged after BMI in LE but not HE rats, while resting discharge rates were increased after BMI independent of estrogen status. By contrast, the selective GABAA receptor agonist, muscimol (50 μM, 30 μl), significantly reduced the magnitude and duration of ATP-evoked activity, resting discharge rate, and cutaneous RF area of TMJ neurons in LE and HE rats, whereas lower doses (5 μM) affected only units from LE rats. Protein levels of GABAA receptor β3 isoform at the Vc/C1–2 region were similar for HE and LE rats. These results suggest that GABAergic mechanisms contribute significantly to background discharge rates and TMJ-evoked input to superficial laminae neurons at the Vc/C1–2 region. Estrogen status may gate the magnitude of GABAergic influence on TMJ neurons at the earliest stages of nociceptive processing at the spinomedullary region." @default.
- W2168647145 created "2016-06-24" @default.
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- W2168647145 creator A5056722416 @default.
- W2168647145 date "2014-02-01" @default.
- W2168647145 modified "2023-09-30" @default.
- W2168647145 title "GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status" @default.
- W2168647145 cites W1502488470 @default.
- W2168647145 cites W1509009650 @default.
- W2168647145 cites W1538927534 @default.
- W2168647145 cites W1557591071 @default.
- W2168647145 cites W1932154717 @default.
- W2168647145 cites W1945096581 @default.
- W2168647145 cites W1965316646 @default.
- W2168647145 cites W1969591072 @default.
- W2168647145 cites W1970261756 @default.
- W2168647145 cites W1972380422 @default.
- W2168647145 cites W1973639457 @default.
- W2168647145 cites W1976547137 @default.
- W2168647145 cites W1981680359 @default.
- W2168647145 cites W1982002301 @default.
- W2168647145 cites W1982862745 @default.
- W2168647145 cites W1985780560 @default.
- W2168647145 cites W1989133677 @default.
- W2168647145 cites W1989594779 @default.
- W2168647145 cites W1989920473 @default.
- W2168647145 cites W1993427764 @default.
- W2168647145 cites W1995418087 @default.
- W2168647145 cites W1996102619 @default.
- W2168647145 cites W2001185696 @default.
- W2168647145 cites W2001368375 @default.
- W2168647145 cites W2003533181 @default.
- W2168647145 cites W2003566564 @default.
- W2168647145 cites W2004551214 @default.
- W2168647145 cites W2004934852 @default.
- W2168647145 cites W2007803278 @default.
- W2168647145 cites W2010125977 @default.
- W2168647145 cites W2010825018 @default.
- W2168647145 cites W2011606970 @default.
- W2168647145 cites W2012912591 @default.
- W2168647145 cites W2014760247 @default.
- W2168647145 cites W2015395924 @default.
- W2168647145 cites W2021450290 @default.
- W2168647145 cites W2029015778 @default.
- W2168647145 cites W2031228990 @default.
- W2168647145 cites W2033388267 @default.
- W2168647145 cites W2035298313 @default.
- W2168647145 cites W2036622789 @default.
- W2168647145 cites W2036804461 @default.
- W2168647145 cites W2037099123 @default.
- W2168647145 cites W2038300767 @default.
- W2168647145 cites W2038530539 @default.
- W2168647145 cites W2038890115 @default.
- W2168647145 cites W2042856479 @default.
- W2168647145 cites W2045898875 @default.
- W2168647145 cites W2047615113 @default.
- W2168647145 cites W2048256601 @default.
- W2168647145 cites W2049477991 @default.
- W2168647145 cites W2056060709 @default.
- W2168647145 cites W2056820580 @default.
- W2168647145 cites W2059635921 @default.
- W2168647145 cites W2060421839 @default.
- W2168647145 cites W2063223361 @default.
- W2168647145 cites W2066468959 @default.
- W2168647145 cites W2068215064 @default.
- W2168647145 cites W2074409154 @default.
- W2168647145 cites W2076187030 @default.
- W2168647145 cites W2076405008 @default.
- W2168647145 cites W2076756254 @default.
- W2168647145 cites W2078264080 @default.
- W2168647145 cites W2085513207 @default.
- W2168647145 cites W2092439619 @default.
- W2168647145 cites W2101178259 @default.
- W2168647145 cites W2103715310 @default.
- W2168647145 cites W2114719580 @default.
- W2168647145 cites W2131394216 @default.
- W2168647145 cites W2132726881 @default.
- W2168647145 cites W2133316133 @default.
- W2168647145 cites W2144172299 @default.
- W2168647145 cites W2145865543 @default.
- W2168647145 cites W2151327079 @default.
- W2168647145 cites W2158188279 @default.
- W2168647145 cites W2165008618 @default.
- W2168647145 cites W2199408538 @default.
- W2168647145 cites W2233174934 @default.
- W2168647145 cites W2300898136 @default.
- W2168647145 cites W4255329297 @default.
- W2168647145 doi "https://doi.org/10.1016/j.neuroscience.2013.11.053" @default.
- W2168647145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4045648" @default.
- W2168647145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24316475" @default.
- W2168647145 hasPublicationYear "2014" @default.
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