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- W2168665598 abstract "Recent studies indicate the association of matrix metalloproteinases (MMPs) transformation from varicoseveins with tissue inhibitors of metalloproteinases (TIMPs) activity alterations. This study aims to investigate MMPs andTIMPs in varicose veins, corresponding to CEAP II-III stages (simple varices) and CEAP IV-VI (complicated varices),following markers distribution profile, their morphology being associated to the clincal stage. The group of study wascomposed of 13 patients with varicose disease: 8 cases in CEAP II-III stage, 5 cases in IV-VI CEAP stage. After surgicaltreatment, the prelevated fragments, fixed in buffered formalin, were paraffin-embedded and initially processed forhistopathological examination. In order to perform immunohistochemical analysis, anti-MMP-2, anti-MMP-9, anti-TIMP-1 antibodies were used. For both investigated groups, our results revealed evident differences between the twoinvestigated MMPs. In a small number of analyzed cases we evidentiated an inconstant MMP-2 presence. On the otherhand, MMP-9 was expressed in all cases, in a parallel manner to TIMP-1. Consequently, our data indicate a MMP-9 andTIMP-1 involvement in venous insuffiency matrix remodeling." @default.
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- W2168665598 date "2010-06-09" @default.
- W2168665598 modified "2023-10-16" @default.
- W2168665598 title "Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in varicose veins" @default.
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