Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168678220> ?p ?o ?g. }
- W2168678220 abstract "Recently, the cyclophilin A (CyPA)-binding region of the HIV-1 capsid protein was identified as a viral determinant involved in the post-entry restriction in Old World monkey cells. Here, we constructed a panel of HIV-1-based lentiviral vectors (LVs) that contain either mutations in the CyPA-binding region or the CyPA-binding region of the related viruses HIV-1 group O and HIV-2. We demonstrated that amino-acid changes in the CyPA-binding region of the capsid can alter the phenotype of the virus resulting in CyPA-independent infection in human cells and nonrestricted infection in simian cells. Combining these data with the available structural data, we speculate that reduced affinity of the capsid for CyPA is associated with an unrestricted infection of simian cells. In addition, we observed that primary rhesus macaque peripheral blood mononuclear cells could be transduced efficiently by the LV that contained the CyPA-binding region of HIV-2. Therefore, this LV might be very useful for long-term safety studies in large animal models like rhesus macaques." @default.
- W2168678220 created "2016-06-24" @default.
- W2168678220 creator A5001036014 @default.
- W2168678220 date "2009-01-01" @default.
- W2168678220 modified "2023-09-28" @default.
- W2168678220 title "Cellular factors involved in HIV-1 replication" @default.
- W2168678220 cites W1514779641 @default.
- W2168678220 cites W1551243371 @default.
- W2168678220 cites W1566969252 @default.
- W2168678220 cites W1844569659 @default.
- W2168678220 cites W1876294625 @default.
- W2168678220 cites W1965849042 @default.
- W2168678220 cites W1966649325 @default.
- W2168678220 cites W1971226986 @default.
- W2168678220 cites W1972558420 @default.
- W2168678220 cites W1974422884 @default.
- W2168678220 cites W1975534778 @default.
- W2168678220 cites W1977487387 @default.
- W2168678220 cites W1977990574 @default.
- W2168678220 cites W1983360226 @default.
- W2168678220 cites W1987128366 @default.
- W2168678220 cites W1988976525 @default.
- W2168678220 cites W1991069890 @default.
- W2168678220 cites W1991852558 @default.
- W2168678220 cites W1992969547 @default.
- W2168678220 cites W1993089489 @default.
- W2168678220 cites W1997890514 @default.
- W2168678220 cites W2001375348 @default.
- W2168678220 cites W2002039213 @default.
- W2168678220 cites W2010458160 @default.
- W2168678220 cites W2013556374 @default.
- W2168678220 cites W2017387896 @default.
- W2168678220 cites W2018729299 @default.
- W2168678220 cites W2020498024 @default.
- W2168678220 cites W2020597127 @default.
- W2168678220 cites W2022480880 @default.
- W2168678220 cites W2026948089 @default.
- W2168678220 cites W2028400386 @default.
- W2168678220 cites W2033388772 @default.
- W2168678220 cites W2040706842 @default.
- W2168678220 cites W2047953384 @default.
- W2168678220 cites W2050400345 @default.
- W2168678220 cites W2051909045 @default.
- W2168678220 cites W2052022412 @default.
- W2168678220 cites W2056832018 @default.
- W2168678220 cites W2062049977 @default.
- W2168678220 cites W2062639699 @default.
- W2168678220 cites W2067367623 @default.
- W2168678220 cites W2068880841 @default.
- W2168678220 cites W2076811542 @default.
- W2168678220 cites W2078248506 @default.
- W2168678220 cites W2082314789 @default.
- W2168678220 cites W2089852194 @default.
- W2168678220 cites W2090592602 @default.
- W2168678220 cites W2103314023 @default.
- W2168678220 cites W2110609746 @default.
- W2168678220 cites W2111401970 @default.
- W2168678220 cites W2111673257 @default.
- W2168678220 cites W2112969174 @default.
- W2168678220 cites W2114859237 @default.
- W2168678220 cites W2116773729 @default.
- W2168678220 cites W2118115182 @default.
- W2168678220 cites W2121753315 @default.
- W2168678220 cites W2124267461 @default.
- W2168678220 cites W2131912633 @default.
- W2168678220 cites W2132278469 @default.
- W2168678220 cites W2135035609 @default.
- W2168678220 cites W2138468602 @default.
- W2168678220 cites W2139119391 @default.
- W2168678220 cites W2143015604 @default.
- W2168678220 cites W2145848202 @default.
- W2168678220 cites W2145957790 @default.
- W2168678220 cites W2147703962 @default.
- W2168678220 cites W2149277009 @default.
- W2168678220 cites W2149730509 @default.
- W2168678220 cites W2152389793 @default.
- W2168678220 cites W2154853638 @default.
- W2168678220 cites W2156829363 @default.
- W2168678220 cites W2157835135 @default.
- W2168678220 cites W2158730314 @default.
- W2168678220 cites W2166197351 @default.
- W2168678220 cites W2168298661 @default.
- W2168678220 cites W2169274637 @default.
- W2168678220 cites W2169732011 @default.
- W2168678220 cites W2170482017 @default.
- W2168678220 hasPublicationYear "2009" @default.
- W2168678220 type Work @default.
- W2168678220 sameAs 2168678220 @default.
- W2168678220 citedByCount "0" @default.
- W2168678220 crossrefType "journal-article" @default.
- W2168678220 hasAuthorship W2168678220A5001036014 @default.
- W2168678220 hasConcept C137061746 @default.
- W2168678220 hasConcept C140704245 @default.
- W2168678220 hasConcept C151730666 @default.
- W2168678220 hasConcept C153911025 @default.
- W2168678220 hasConcept C159047783 @default.
- W2168678220 hasConcept C202751555 @default.
- W2168678220 hasConcept C202878990 @default.
- W2168678220 hasConcept C2522874641 @default.
- W2168678220 hasConcept C2777995582 @default.