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- W2168698734 abstract "Abstract The coelomocytes of Caenorhabditis elegans are scavenger cells that continuously and nonspecifically endocytose fluid from the pseudocoelom (body cavity). Green fluorescent protein (GFP) secreted into the pseudocoelom from body wall muscle cells is endocytosed and degraded by coelomocytes. We show that toxin-mediated ablation of coelomocytes results in viable animals that fail to endocytose pseudocoelomic GFP, indicating that endocytosis by coelomocytes is not essential for growth or survival of C. elegans under normal laboratory conditions. We examined known viable endocytosis mutants, and performed RNAi for other known endocytosis genes, for coelomocyte uptake defective (Cup) phenotypes. We also screened for new genes involved in endocytosis by isolating viable mutants with Cup defects; this screen identified 14 different genes, many with multiple alleles. A variety of Cup terminal phenotypes were observed, consistent with defects at various steps in the endocytic pathway. Available molecular information indicates that the Cup mutant screen has identified novel components of the endocytosis machinery that are conserved in mammals but not in Saccharomyces cerevisiae, the only other organism for which large-scale genetic screens for endocytosis mutants have been performed." @default.
- W2168698734 created "2016-06-24" @default.
- W2168698734 creator A5069328543 @default.
- W2168698734 creator A5073848674 @default.
- W2168698734 date "2001-09-01" @default.
- W2168698734 modified "2023-10-02" @default.
- W2168698734 title "Genetic Analysis of Endocytosis in <i>Caenorhabditis elegans</i>: Coelomocyte Uptake Defective Mutants" @default.
- W2168698734 cites W106780798 @default.
- W2168698734 cites W126794640 @default.
- W2168698734 cites W1486450190 @default.
- W2168698734 cites W1490641559 @default.
- W2168698734 cites W1508614407 @default.
- W2168698734 cites W1509564548 @default.
- W2168698734 cites W1510849499 @default.
- W2168698734 cites W1515622122 @default.
- W2168698734 cites W1518809734 @default.
- W2168698734 cites W1524778592 @default.
- W2168698734 cites W1526102413 @default.
- W2168698734 cites W1533988685 @default.
- W2168698734 cites W1548405860 @default.
- W2168698734 cites W1550712876 @default.
- W2168698734 cites W1581412826 @default.
- W2168698734 cites W1587363777 @default.
- W2168698734 cites W1647075334 @default.
- W2168698734 cites W173218542 @default.
- W2168698734 cites W1785785489 @default.
- W2168698734 cites W1840564118 @default.
- W2168698734 cites W1847602617 @default.
- W2168698734 cites W1914196681 @default.
- W2168698734 cites W1915093727 @default.
- W2168698734 cites W1936931129 @default.
- W2168698734 cites W1944127002 @default.
- W2168698734 cites W1976514154 @default.
- W2168698734 cites W1979232276 @default.
- W2168698734 cites W1985518475 @default.
- W2168698734 cites W1987248266 @default.
- W2168698734 cites W1987736310 @default.
- W2168698734 cites W1987984945 @default.
- W2168698734 cites W1989760629 @default.
- W2168698734 cites W1997966048 @default.
- W2168698734 cites W1999402559 @default.
- W2168698734 cites W2007277428 @default.
- W2168698734 cites W2007307174 @default.
- W2168698734 cites W2007599495 @default.
- W2168698734 cites W2010241113 @default.
- W2168698734 cites W2010502904 @default.
- W2168698734 cites W2015272827 @default.
- W2168698734 cites W2017949964 @default.
- W2168698734 cites W2022159036 @default.
- W2168698734 cites W2026740840 @default.
- W2168698734 cites W2032579724 @default.
- W2168698734 cites W2033365440 @default.
- W2168698734 cites W2033978875 @default.
- W2168698734 cites W2036083888 @default.
- W2168698734 cites W2039247434 @default.
- W2168698734 cites W2040954100 @default.
- W2168698734 cites W2041948818 @default.
- W2168698734 cites W2042863201 @default.
- W2168698734 cites W2048912204 @default.
- W2168698734 cites W2049240980 @default.
- W2168698734 cites W2051919099 @default.
- W2168698734 cites W2058282339 @default.
- W2168698734 cites W2060797732 @default.
- W2168698734 cites W2065365365 @default.
- W2168698734 cites W2066123272 @default.
- W2168698734 cites W2074693969 @default.
- W2168698734 cites W2089827948 @default.
- W2168698734 cites W2095778900 @default.
- W2168698734 cites W2096196335 @default.
- W2168698734 cites W2104922795 @default.
- W2168698734 cites W2109501447 @default.
- W2168698734 cites W2118393965 @default.
- W2168698734 cites W2118858388 @default.
- W2168698734 cites W2121357228 @default.
- W2168698734 cites W2122163057 @default.
- W2168698734 cites W2122356356 @default.
- W2168698734 cites W2126896262 @default.
- W2168698734 cites W2127230663 @default.
- W2168698734 cites W2127392024 @default.
- W2168698734 cites W2130264382 @default.
- W2168698734 cites W2131121107 @default.
- W2168698734 cites W2131411591 @default.
- W2168698734 cites W2131824360 @default.
- W2168698734 cites W2133194146 @default.
- W2168698734 cites W2133263385 @default.
- W2168698734 cites W2134336339 @default.
- W2168698734 cites W2135021919 @default.
- W2168698734 cites W2136784809 @default.
- W2168698734 cites W2144420636 @default.
- W2168698734 cites W2149813111 @default.
- W2168698734 cites W2149907284 @default.
- W2168698734 cites W2153155373 @default.
- W2168698734 cites W2153689647 @default.
- W2168698734 cites W2158538184 @default.
- W2168698734 cites W2159803165 @default.
- W2168698734 cites W2167036552 @default.
- W2168698734 cites W2168909179 @default.
- W2168698734 cites W2169441235 @default.