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• W2168702943 abstract "Over the past decade, clinical development of natriuretic peptide analogues as drug therapy for acute heart failure has sparked a wide range of interests to seek other endogenous vasoactive peptide systems that are operative as adaptive responders in human heart failure. With rapid advances in the molecular understanding of heart failure pathogenesis, several novel neurohormonal systems have been identified and more are under study. Bringing a potential therapeutic concept from bench to bedside today often involves a prerequisite set of animal and human studies. However, much of the attention in recent years has focused on identifying what the best clinical end-points should be or what the sample size should be in order to power statistical significance. Sometimes the fundamental mechanisms of action are overlooked with the rush to clinical implications. Opportunities to refine our thinking in the exploitation of such neurohormonal agonists/antagonists can be easily missed.Davis and colleagues have extended our understanding of a new neurohormone and its pathophysiological role in heart failure1. Urocortin is actually a group of peptides belonging to the corticotrophin-releasing factor (CRF) family, with other members including urocortin 1, urocortin 2, and urocortin 3. It is interesting to point out that the urocortin system has been conserved throughout evolution in vertebrates all the way back to the amphibian sauvagine.2 Such evolutionary conservation usually suggests that the peptide subserves an important adaptive role. This system appears to release corticosteroids in response to stress, at the same time contributing to some ‘cardioprotective’ … *Corresponding author. Tel: +1 216 444-3410; fax: +1 216 636-0063. E-mail address: francig{at}ccf.org" @default.
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• W2168702943 date "2007-10-14" @default.
• W2168702943 modified "2023-09-25" @default.
• W2168702943 title "Exploring new drugs for heart failure: the case of urocortin" @default.
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• W2168702943 doi "https://doi.org/10.1093/eurheartj/ehm413" @default.
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