Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168713857> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2168713857 endingPage "1406" @default.
- W2168713857 startingPage "1401" @default.
- W2168713857 abstract "Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation, where poorly soluble acidic AMG 009 molecule was intimately mixed and compressed together with a basic pH modifier (e.g., sodium carbonate) and nucleation inhibitor hydroxypropyl methylcellulose K100 LV (HPMC K100 LV), was demonstrated previously. However, not all acidic or basic drugs are compatible with basic or acidic pH modifiers either chemically or physically. The objective of this study is to investigate whether similar dissolution enhancement of AMG 009 can be achieved from a bilayer dosage form, where AMG 009 and sodium carbonate are placed in a separate layer with or without the addition of HPMC K100 LV in each layer. Study results indicate that HPMC K100 LV-containing bilayer dosage forms gained similar dissolution enhancement as matrix dosage forms did. Bilayer dosage forms without HPMC K100 LV benefitted the least from dissolution enhancement." @default.
- W2168713857 created "2016-06-24" @default.
- W2168713857 creator A5001556889 @default.
- W2168713857 creator A5022192888 @default.
- W2168713857 creator A5024441307 @default.
- W2168713857 creator A5032054827 @default.
- W2168713857 date "2011-10-20" @default.
- W2168713857 modified "2023-10-06" @default.
- W2168713857 title "Enhancing and Sustaining AMG 009 Dissolution from a Bilayer Oral Solid Dosage Form via Microenvironmental pH Modulation and Supersaturation" @default.
- W2168713857 cites W1967688016 @default.
- W2168713857 cites W1995870551 @default.
- W2168713857 cites W2012750471 @default.
- W2168713857 cites W2016662966 @default.
- W2168713857 cites W2029147126 @default.
- W2168713857 cites W2030951340 @default.
- W2168713857 cites W2039675557 @default.
- W2168713857 cites W2082875971 @default.
- W2168713857 cites W2083513185 @default.
- W2168713857 cites W2092053998 @default.
- W2168713857 cites W2100473852 @default.
- W2168713857 cites W2137002405 @default.
- W2168713857 cites W2160064817 @default.
- W2168713857 cites W4239750817 @default.
- W2168713857 doi "https://doi.org/10.1208/s12249-011-9710-2" @default.
- W2168713857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3225540" @default.
- W2168713857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22012200" @default.
- W2168713857 hasPublicationYear "2011" @default.
- W2168713857 type Work @default.
- W2168713857 sameAs 2168713857 @default.
- W2168713857 citedByCount "13" @default.
- W2168713857 countsByYear W21687138572013 @default.
- W2168713857 countsByYear W21687138572014 @default.
- W2168713857 countsByYear W21687138572015 @default.
- W2168713857 countsByYear W21687138572016 @default.
- W2168713857 countsByYear W21687138572018 @default.
- W2168713857 countsByYear W21687138572020 @default.
- W2168713857 countsByYear W21687138572023 @default.
- W2168713857 crossrefType "journal-article" @default.
- W2168713857 hasAuthorship W2168713857A5001556889 @default.
- W2168713857 hasAuthorship W2168713857A5022192888 @default.
- W2168713857 hasAuthorship W2168713857A5024441307 @default.
- W2168713857 hasAuthorship W2168713857A5032054827 @default.
- W2168713857 hasBestOaLocation W21687138572 @default.
- W2168713857 hasConcept C106487976 @default.
- W2168713857 hasConcept C127413603 @default.
- W2168713857 hasConcept C155574463 @default.
- W2168713857 hasConcept C178790620 @default.
- W2168713857 hasConcept C185592680 @default.
- W2168713857 hasConcept C192157962 @default.
- W2168713857 hasConcept C192562407 @default.
- W2168713857 hasConcept C200447597 @default.
- W2168713857 hasConcept C41625074 @default.
- W2168713857 hasConcept C42360764 @default.
- W2168713857 hasConcept C43617362 @default.
- W2168713857 hasConcept C55493867 @default.
- W2168713857 hasConcept C77281830 @default.
- W2168713857 hasConcept C88380143 @default.
- W2168713857 hasConceptScore W2168713857C106487976 @default.
- W2168713857 hasConceptScore W2168713857C127413603 @default.
- W2168713857 hasConceptScore W2168713857C155574463 @default.
- W2168713857 hasConceptScore W2168713857C178790620 @default.
- W2168713857 hasConceptScore W2168713857C185592680 @default.
- W2168713857 hasConceptScore W2168713857C192157962 @default.
- W2168713857 hasConceptScore W2168713857C192562407 @default.
- W2168713857 hasConceptScore W2168713857C200447597 @default.
- W2168713857 hasConceptScore W2168713857C41625074 @default.
- W2168713857 hasConceptScore W2168713857C42360764 @default.
- W2168713857 hasConceptScore W2168713857C43617362 @default.
- W2168713857 hasConceptScore W2168713857C55493867 @default.
- W2168713857 hasConceptScore W2168713857C77281830 @default.
- W2168713857 hasConceptScore W2168713857C88380143 @default.
- W2168713857 hasIssue "4" @default.
- W2168713857 hasLocation W21687138571 @default.
- W2168713857 hasLocation W21687138572 @default.
- W2168713857 hasLocation W21687138573 @default.
- W2168713857 hasLocation W21687138574 @default.
- W2168713857 hasOpenAccess W2168713857 @default.
- W2168713857 hasPrimaryLocation W21687138571 @default.
- W2168713857 hasRelatedWork W2077563626 @default.
- W2168713857 hasRelatedWork W2151520572 @default.
- W2168713857 hasRelatedWork W2158069230 @default.
- W2168713857 hasRelatedWork W2387982746 @default.
- W2168713857 hasRelatedWork W2736150726 @default.
- W2168713857 hasRelatedWork W2787401130 @default.
- W2168713857 hasRelatedWork W2790641115 @default.
- W2168713857 hasRelatedWork W2905153366 @default.
- W2168713857 hasRelatedWork W3014595908 @default.
- W2168713857 hasRelatedWork W3034516454 @default.
- W2168713857 hasVolume "12" @default.
- W2168713857 isParatext "false" @default.
- W2168713857 isRetracted "false" @default.
- W2168713857 magId "2168713857" @default.
- W2168713857 workType "article" @default.