FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168752138> ?p ?o ?g. }

• W2168752138 endingPage "5296" @default.
• W2168752138 startingPage "5288" @default.
• W2168752138 abstract "ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV), a human tumor virus, encodes two homologous membrane-associated E3 ubiquitin ligases, modulator of immune recognition 1 (MIR1) and MIR2, to evade host immunity. Both MIR1 and MIR2 downregulate the surface expression of major histocompatibility complex class I (MHC I) molecules through ubiquitin-mediated endocytosis followed by lysosomal degradation. Since MIR2 additionally downregulates a costimulatory molecule (B7-2) and an integrin ligand (intercellular adhesion molecule 1 [ICAM-1]), MIR2 is thought to be a more important molecule for immune evasion than MIR1; however, the molecular basis of the MIR2 substrate specificity remains unclear. To address this issue, we determined which regions of B7-2 and MIR2 are required for MIR2-mediated B7-2 downregulation. Experiments with chimeras made by swapping domains between human B7-2 and CD8α, a non-MIR2 substrate, and between MIR1 and MIR2 demonstrated a significant contribution of the juxtamembrane (JM) region of B7-2 and the intertransmembrane (ITM) region of MIR2 to MIR2-mediated downregulation. Structure prediction and mutagenesis analyses indicate that Phe119 and Ser120 in the MIR2 ITM region and Asp244 in the B7-2 JM region contribute to the recognition of B7-2 by MIR2. This finding provides new insight into the molecular basis of substrate recognition by MIR family members." @default.
• W2168752138 created "2016-06-24" @default.
• W2168752138 creator A5052281594 @default.
• W2168752138 creator A5059527715 @default.
• W2168752138 creator A5067418024 @default.
• W2168752138 creator A5074728289 @default.
• W2168752138 creator A5075257610 @default.
• W2168752138 creator A5087321727 @default.
• W2168752138 creator A5088766275 @default.
• W2168752138 creator A5029154314 @default.
• W2168752138 creator A5035804298 @default.
• W2168752138 date "2012-05-01" @default.
• W2168752138 modified "2023-10-14" @default.
• W2168752138 title "The Intertransmembrane Region of Kaposi's Sarcoma-Associated Herpesvirus Modulator of Immune Recognition 2 Contributes to B7-2 Downregulation" @default.
• W2168752138 cites W1669828090 @default.
• W2168752138 cites W1965969172 @default.
• W2168752138 cites W1969298752 @default.
• W2168752138 cites W1977922844 @default.
• W2168752138 cites W1989525395 @default.
• W2168752138 cites W1998282199 @default.
• W2168752138 cites W2006233454 @default.
• W2168752138 cites W2008116827 @default.
• W2168752138 cites W2009745195 @default.
• W2168752138 cites W2017954030 @default.
• W2168752138 cites W2021658855 @default.
• W2168752138 cites W2023256284 @default.
• W2168752138 cites W2029667189 @default.
• W2168752138 cites W2031623763 @default.
• W2168752138 cites W2033352476 @default.
• W2168752138 cites W2040809566 @default.
• W2168752138 cites W2046518207 @default.
• W2168752138 cites W2050333027 @default.
• W2168752138 cites W2055569374 @default.
• W2168752138 cites W2060736883 @default.
• W2168752138 cites W2060913542 @default.
• W2168752138 cites W2074114336 @default.
• W2168752138 cites W2074876842 @default.
• W2168752138 cites W2081376834 @default.
• W2168752138 cites W2082878575 @default.
• W2168752138 cites W2084896925 @default.
• W2168752138 cites W2085279345 @default.
• W2168752138 cites W2086196885 @default.
• W2168752138 cites W2092661111 @default.
• W2168752138 cites W2096216895 @default.
• W2168752138 cites W2105573149 @default.
• W2168752138 cites W2117919289 @default.
• W2168752138 cites W2118913742 @default.
• W2168752138 cites W2124533615 @default.
• W2168752138 cites W2124547357 @default.
• W2168752138 cites W2132262459 @default.
• W2168752138 cites W2144720739 @default.
• W2168752138 cites W2153918116 @default.
• W2168752138 cites W2159163386 @default.
• W2168752138 cites W2166935154 @default.
• W2168752138 doi "https://doi.org/10.1128/jvi.00219-12" @default.
• W2168752138 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3347341" @default.
• W2168752138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22379101" @default.
• W2168752138 hasPublicationYear "2012" @default.
• W2168752138 type Work @default.
• W2168752138 sameAs 2168752138 @default.
• W2168752138 citedByCount "13" @default.
• W2168752138 countsByYear W21687521382012 @default.
• W2168752138 countsByYear W21687521382013 @default.
• W2168752138 countsByYear W21687521382014 @default.
• W2168752138 countsByYear W21687521382015 @default.
• W2168752138 countsByYear W21687521382018 @default.
• W2168752138 countsByYear W21687521382019 @default.
• W2168752138 countsByYear W21687521382021 @default.
• W2168752138 countsByYear W21687521382022 @default.
• W2168752138 countsByYear W21687521382023 @default.
• W2168752138 crossrefType "journal-article" @default.
• W2168752138 hasAuthorship W2168752138A5029154314 @default.
• W2168752138 hasAuthorship W2168752138A5035804298 @default.
• W2168752138 hasAuthorship W2168752138A5052281594 @default.
• W2168752138 hasAuthorship W2168752138A5059527715 @default.
• W2168752138 hasAuthorship W2168752138A5067418024 @default.
• W2168752138 hasAuthorship W2168752138A5074728289 @default.
• W2168752138 hasAuthorship W2168752138A5075257610 @default.
• W2168752138 hasAuthorship W2168752138A5087321727 @default.
• W2168752138 hasAuthorship W2168752138A5088766275 @default.
• W2168752138 hasBestOaLocation W21687521381 @default.
• W2168752138 hasConcept C104317684 @default.
• W2168752138 hasConcept C127561419 @default.
• W2168752138 hasConcept C139770010 @default.
• W2168752138 hasConcept C159047783 @default.
• W2168752138 hasConcept C170493617 @default.
• W2168752138 hasConcept C170627219 @default.
• W2168752138 hasConcept C207936829 @default.
• W2168752138 hasConcept C25602115 @default.
• W2168752138 hasConcept C54355233 @default.
• W2168752138 hasConcept C86803240 @default.
• W2168752138 hasConcept C8891405 @default.
• W2168752138 hasConcept C95444343 @default.
• W2168752138 hasConceptScore W2168752138C104317684 @default.
• W2168752138 hasConceptScore W2168752138C127561419 @default.
• W2168752138 hasConceptScore W2168752138C139770010 @default.
• W2168752138 hasConceptScore W2168752138C159047783 @default.
• W2168752138 hasConceptScore W2168752138C170493617 @default.

• next