Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168765510> ?p ?o ?g. }
- W2168765510 endingPage "10106" @default.
- W2168765510 startingPage "10098" @default.
- W2168765510 abstract "Translation in baker's yeast involves the coordinated interaction of 200,000 ribosomes, 3,000,000 tRNAs and between 15,000 and 60,000 mRNAs. It is currently unknown whether this specific constellation of components has particular relevance for the requirements of the yeast proteome, or whether this is simply a frozen accident. Our study uses a computational simulation model of the genome-wide translational apparatus of yeast to explore quantitatively which combinations of mRNAs, ribosomes and tRNAs can produce viable proteomes. Surprisingly, we find that if we only consider total translational activity over time without regard to composition of the proteome, then there are many and widely differing combinations that can generate equivalent synthesis yields. In contrast, translational activity required for generating specific proteomes can only be achieved within a much more constrained parameter space. Furthermore, we find that strongly ribosome limited regimes are optimal for cells in that they are resource efficient and simplify the dynamics of the system." @default.
- W2168765510 created "2016-06-24" @default.
- W2168765510 creator A5064834508 @default.
- W2168765510 creator A5072779904 @default.
- W2168765510 date "2012-09-08" @default.
- W2168765510 modified "2023-09-30" @default.
- W2168765510 title "The architecture of eukaryotic translation" @default.
- W2168765510 cites W1551922596 @default.
- W2168765510 cites W1572640010 @default.
- W2168765510 cites W1602977070 @default.
- W2168765510 cites W1713545742 @default.
- W2168765510 cites W1733413688 @default.
- W2168765510 cites W1971739920 @default.
- W2168765510 cites W1973290333 @default.
- W2168765510 cites W1973448897 @default.
- W2168765510 cites W1975695704 @default.
- W2168765510 cites W1977046089 @default.
- W2168765510 cites W1979632388 @default.
- W2168765510 cites W1980447983 @default.
- W2168765510 cites W1984708728 @default.
- W2168765510 cites W1990755062 @default.
- W2168765510 cites W1992927069 @default.
- W2168765510 cites W2000840693 @default.
- W2168765510 cites W2008410413 @default.
- W2168765510 cites W2014315271 @default.
- W2168765510 cites W2025921132 @default.
- W2168765510 cites W2031536080 @default.
- W2168765510 cites W2033244618 @default.
- W2168765510 cites W2035707844 @default.
- W2168765510 cites W2036762446 @default.
- W2168765510 cites W2047483227 @default.
- W2168765510 cites W2059426284 @default.
- W2168765510 cites W2062119499 @default.
- W2168765510 cites W2068872007 @default.
- W2168765510 cites W2076278017 @default.
- W2168765510 cites W2077082798 @default.
- W2168765510 cites W2079347458 @default.
- W2168765510 cites W2079517684 @default.
- W2168765510 cites W2102038046 @default.
- W2168765510 cites W2102221598 @default.
- W2168765510 cites W2110274742 @default.
- W2168765510 cites W2112945902 @default.
- W2168765510 cites W2115585439 @default.
- W2168765510 cites W2115899980 @default.
- W2168765510 cites W2127966910 @default.
- W2168765510 cites W2139956963 @default.
- W2168765510 cites W2143428005 @default.
- W2168765510 cites W2150237478 @default.
- W2168765510 cites W2154332314 @default.
- W2168765510 cites W2155418451 @default.
- W2168765510 cites W2160689765 @default.
- W2168765510 cites W2162537420 @default.
- W2168765510 cites W2163223478 @default.
- W2168765510 cites W2169736926 @default.
- W2168765510 cites W2171680748 @default.
- W2168765510 cites W2917136151 @default.
- W2168765510 cites W4245546812 @default.
- W2168765510 doi "https://doi.org/10.1093/nar/gks825" @default.
- W2168765510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3488257" @default.
- W2168765510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22965119" @default.
- W2168765510 hasPublicationYear "2012" @default.
- W2168765510 type Work @default.
- W2168765510 sameAs 2168765510 @default.
- W2168765510 citedByCount "45" @default.
- W2168765510 countsByYear W21687655102013 @default.
- W2168765510 countsByYear W21687655102014 @default.
- W2168765510 countsByYear W21687655102015 @default.
- W2168765510 countsByYear W21687655102016 @default.
- W2168765510 countsByYear W21687655102017 @default.
- W2168765510 countsByYear W21687655102018 @default.
- W2168765510 countsByYear W21687655102019 @default.
- W2168765510 countsByYear W21687655102020 @default.
- W2168765510 countsByYear W21687655102021 @default.
- W2168765510 countsByYear W21687655102023 @default.
- W2168765510 crossrefType "journal-article" @default.
- W2168765510 hasAuthorship W2168765510A5064834508 @default.
- W2168765510 hasAuthorship W2168765510A5072779904 @default.
- W2168765510 hasBestOaLocation W21687655101 @default.
- W2168765510 hasConcept C104317684 @default.
- W2168765510 hasConcept C104397665 @default.
- W2168765510 hasConcept C105580179 @default.
- W2168765510 hasConcept C141231307 @default.
- W2168765510 hasConcept C149364088 @default.
- W2168765510 hasConcept C182325514 @default.
- W2168765510 hasConcept C2779222958 @default.
- W2168765510 hasConcept C3675279 @default.
- W2168765510 hasConcept C4718897 @default.
- W2168765510 hasConcept C54355233 @default.
- W2168765510 hasConcept C67705224 @default.
- W2168765510 hasConcept C70721500 @default.
- W2168765510 hasConcept C86803240 @default.
- W2168765510 hasConcept C88478588 @default.
- W2168765510 hasConceptScore W2168765510C104317684 @default.
- W2168765510 hasConceptScore W2168765510C104397665 @default.
- W2168765510 hasConceptScore W2168765510C105580179 @default.
- W2168765510 hasConceptScore W2168765510C141231307 @default.
- W2168765510 hasConceptScore W2168765510C149364088 @default.
- W2168765510 hasConceptScore W2168765510C182325514 @default.