FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168782540> ?p ?o ?g. }

• W2168782540 endingPage "67" @default.
• W2168782540 startingPage "63" @default.
• W2168782540 abstract "Endothelial damage and platelet hyperactivity may play a role in the vascular complications of essential hypertension. Restoration of endothelial function and reduction of increased platelet aggregation in essential hypertension are one of the aims of modern anti-hypertensive therapy. Therefore, the effect of angiotensin converting enzyme (ACE) inhibitors on endothelial and platelet functionsisof interest. In the present study, 23 healthy normotensives and 23 age- and sex-matched patients with non-treated essential hypertension (1st and 2nd stage according to W HO) were investigated. Measurements of endothelial and platelet functions in hypertensives were carried out before therapy, after 1 week of placebo administration, after 1 week and after 1 month of perindopril therapy in a once daily dose of 4mg. Plasma thrombomodulin (ELISA method) and beta-thromboglobulin (radio immunoassay method) were assayed and platelet aggregation (spontaneous and induced by adrenaline) was measured. The values of plasma thrombomodulin, a novel marker of endothelial function, were compared between age- and sex-matched normotensives and hypertensives. A significant decrease of adrenaline-induced platelet aggregation was observed after 1 month of perindopril therapy in comparison with the values before therapy or after 1 week of perindopril therapy ( P < 0.02 and P < 0.05 respectively). There were no significant changesin plasma thrombomodulin or beta-thromboglobulin following therapy. We failed to find significant changes of plasma thrombomodulin in patients in the early stages of hypertension, but its tendency to be higher than in normotensives does not rule out some vascular damage. The inhibitory effect of perindopril on platelet aggregation may be a further advantage of this drug. Since no changes were found after 1 week of therapy, the reduction of adrenaline-induced platelet aggregation after 1 month of therapy may beexplained by an indirect effect of perindopril on platelet function, probably asa result of protective action on the arterial wall." @default.
• W2168782540 created "2016-06-24" @default.
• W2168782540 creator A5022857444 @default.
• W2168782540 creator A5032671727 @default.
• W2168782540 creator A5041203873 @default.
• W2168782540 date "1998-01-01" @default.
• W2168782540 modified "2023-09-23" @default.
• W2168782540 title "Effects of the angiotensin-converting enzyme (ACE) inhibitor perindopril on endothelial and platelet functions in essential hypertension" @default.
• W2168782540 cites W1967585757 @default.
• W2168782540 cites W1973349015 @default.
• W2168782540 cites W1985588753 @default.
• W2168782540 cites W2001967791 @default.
• W2168782540 cites W2025866227 @default.
• W2168782540 cites W2038844601 @default.
• W2168782540 cites W2055534879 @default.
• W2168782540 cites W2064099037 @default.
• W2168782540 cites W2069201471 @default.
• W2168782540 cites W2072046184 @default.
• W2168782540 cites W2083210723 @default.
• W2168782540 cites W2083690031 @default.
• W2168782540 cites W2088480606 @default.
• W2168782540 cites W2111344293 @default.
• W2168782540 cites W2124634432 @default.
• W2168782540 cites W2163712548 @default.
• W2168782540 cites W224626362 @default.
• W2168782540 cites W2326634508 @default.
• W2168782540 cites W2402919560 @default.
• W2168782540 cites W2409286544 @default.
• W2168782540 cites W2419595962 @default.
• W2168782540 cites W2466021936 @default.
• W2168782540 cites W74659383 @default.
• W2168782540 doi "https://doi.org/10.1080/09537109877022" @default.
• W2168782540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16793747" @default.
• W2168782540 hasPublicationYear "1998" @default.
• W2168782540 type Work @default.
• W2168782540 sameAs 2168782540 @default.
• W2168782540 citedByCount "29" @default.
• W2168782540 countsByYear W21687825402012 @default.
• W2168782540 countsByYear W21687825402013 @default.
• W2168782540 countsByYear W21687825402015 @default.
• W2168782540 countsByYear W21687825402019 @default.
• W2168782540 crossrefType "journal-article" @default.
• W2168782540 hasAuthorship W2168782540A5022857444 @default.
• W2168782540 hasAuthorship W2168782540A5032671727 @default.
• W2168782540 hasAuthorship W2168782540A5041203873 @default.
• W2168782540 hasConcept C126322002 @default.
• W2168782540 hasConcept C134018914 @default.
• W2168782540 hasConcept C201267052 @default.
• W2168782540 hasConcept C27016395 @default.
• W2168782540 hasConcept C2776992346 @default.
• W2168782540 hasConcept C2777097880 @default.
• W2168782540 hasConcept C2777292125 @default.
• W2168782540 hasConcept C2779200603 @default.
• W2168782540 hasConcept C2779611605 @default.
• W2168782540 hasConcept C71924100 @default.
• W2168782540 hasConcept C84393581 @default.
• W2168782540 hasConcept C89560881 @default.
• W2168782540 hasConcept C98274493 @default.
• W2168782540 hasConceptScore W2168782540C126322002 @default.
• W2168782540 hasConceptScore W2168782540C134018914 @default.
• W2168782540 hasConceptScore W2168782540C201267052 @default.
• W2168782540 hasConceptScore W2168782540C27016395 @default.
• W2168782540 hasConceptScore W2168782540C2776992346 @default.
• W2168782540 hasConceptScore W2168782540C2777097880 @default.
• W2168782540 hasConceptScore W2168782540C2777292125 @default.
• W2168782540 hasConceptScore W2168782540C2779200603 @default.
• W2168782540 hasConceptScore W2168782540C2779611605 @default.
• W2168782540 hasConceptScore W2168782540C71924100 @default.
• W2168782540 hasConceptScore W2168782540C84393581 @default.
• W2168782540 hasConceptScore W2168782540C89560881 @default.
• W2168782540 hasConceptScore W2168782540C98274493 @default.
• W2168782540 hasIssue "1" @default.
• W2168782540 hasLocation W21687825401 @default.
• W2168782540 hasLocation W21687825402 @default.
• W2168782540 hasOpenAccess W2168782540 @default.
• W2168782540 hasPrimaryLocation W21687825401 @default.
• W2168782540 hasRelatedWork W1966732677 @default.
• W2168782540 hasRelatedWork W1990057429 @default.
• W2168782540 hasRelatedWork W2025888710 @default.
• W2168782540 hasRelatedWork W2053004050 @default.
• W2168782540 hasRelatedWork W2149729817 @default.
• W2168782540 hasRelatedWork W2168782540 @default.
• W2168782540 hasRelatedWork W2384463226 @default.
• W2168782540 hasRelatedWork W2387928918 @default.
• W2168782540 hasRelatedWork W2433762659 @default.
• W2168782540 hasRelatedWork W2991983813 @default.
• W2168782540 hasVolume "9" @default.
• W2168782540 isParatext "false" @default.
• W2168782540 isRetracted "false" @default.
• W2168782540 magId "2168782540" @default.
• W2168782540 workType "article" @default.