FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168856198> ?p ?o ?g. }

• W2168856198 endingPage "9" @default.
• W2168856198 startingPage "3283" @default.
• W2168856198 abstract "The results described in this paper demonstrate that proliferation arrest by low concentrations of tetracyclines, which has previously been shown in experiments with animal tumor systems, can also be achieved in tumor systems of human origin. Tetracyclines specifically inhibit mitochondrial protein synthesis. Prolonged and continuous impairment of protein synthesis inside the mitochondria leads to reduction of the cellular concentration of the polypeptide products which are coded and synthesized within mitochondria. These products are part of the oxidative phosphorylative system of the cell. Long-term tetracycline treatment leads to a decrease of oxidative ATP-generating capacity as monitored by cytochrome c oxidase activity. This may cause severe energetic or metabolic disturbances which explain the proliferation arrest observed. Proliferation arrest, provided that mitochondrial protein synthesis is blocked effectively, is found in vitro as well as in vivo. It is shown that the effect of doxycycline is not limited to cytostasis; prolonged doxycycline treatment is clearly cytotoxic for the tumor cells." @default.
• W2168856198 created "2016-06-24" @default.
• W2168856198 creator A5003952515 @default.
• W2168856198 creator A5037491835 @default.
• W2168856198 creator A5041720794 @default.
• W2168856198 creator A5043505735 @default.
• W2168856198 creator A5059995546 @default.
• W2168856198 creator A5062067604 @default.
• W2168856198 creator A5080884021 @default.
• W2168856198 date "1986-07-01" @default.
• W2168856198 modified "2023-09-23" @default.
• W2168856198 title "Arrest of the proliferation of renal and prostate carcinomas of human origin by inhibition of mitochondrial protein synthesis." @default.
• W2168856198 cites W1419228847 @default.
• W2168856198 cites W1980032214 @default.
• W2168856198 cites W1987002147 @default.
• W2168856198 cites W1987130998 @default.
• W2168856198 cites W2022254645 @default.
• W2168856198 cites W2023513664 @default.
• W2168856198 cites W2063046421 @default.
• W2168856198 cites W2069962012 @default.
• W2168856198 cites W2077353786 @default.
• W2168856198 cites W2102131116 @default.
• W2168856198 cites W2115474596 @default.
• W2168856198 cites W2147846971 @default.
• W2168856198 cites W2410694860 @default.
• W2168856198 cites W2493108661 @default.
• W2168856198 cites W2504429715 @default.
• W2168856198 cites W94071839 @default.
• W2168856198 cites W1544842418 @default.
• W2168856198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3011245" @default.
• W2168856198 hasPublicationYear "1986" @default.
• W2168856198 type Work @default.
• W2168856198 sameAs 2168856198 @default.
• W2168856198 citedByCount "22" @default.
• W2168856198 countsByYear W21688561982013 @default.
• W2168856198 countsByYear W21688561982014 @default.
• W2168856198 countsByYear W21688561982017 @default.
• W2168856198 countsByYear W21688561982021 @default.
• W2168856198 crossrefType "journal-article" @default.
• W2168856198 hasAuthorship W2168856198A5003952515 @default.
• W2168856198 hasAuthorship W2168856198A5037491835 @default.
• W2168856198 hasAuthorship W2168856198A5041720794 @default.
• W2168856198 hasAuthorship W2168856198A5043505735 @default.
• W2168856198 hasAuthorship W2168856198A5059995546 @default.
• W2168856198 hasAuthorship W2168856198A5062067604 @default.
• W2168856198 hasAuthorship W2168856198A5080884021 @default.
• W2168856198 hasConcept C109316439 @default.
• W2168856198 hasConcept C123249941 @default.
• W2168856198 hasConcept C150903083 @default.
• W2168856198 hasConcept C182547069 @default.
• W2168856198 hasConcept C185592680 @default.
• W2168856198 hasConcept C202751555 @default.
• W2168856198 hasConcept C207001950 @default.
• W2168856198 hasConcept C2777179404 @default.
• W2168856198 hasConcept C28859421 @default.
• W2168856198 hasConcept C3675279 @default.
• W2168856198 hasConcept C501593827 @default.
• W2168856198 hasConcept C502942594 @default.
• W2168856198 hasConcept C55493867 @default.
• W2168856198 hasConcept C57600042 @default.
• W2168856198 hasConcept C62112901 @default.
• W2168856198 hasConcept C86803240 @default.
• W2168856198 hasConcept C95444343 @default.
• W2168856198 hasConceptScore W2168856198C109316439 @default.
• W2168856198 hasConceptScore W2168856198C123249941 @default.
• W2168856198 hasConceptScore W2168856198C150903083 @default.
• W2168856198 hasConceptScore W2168856198C182547069 @default.
• W2168856198 hasConceptScore W2168856198C185592680 @default.
• W2168856198 hasConceptScore W2168856198C202751555 @default.
• W2168856198 hasConceptScore W2168856198C207001950 @default.
• W2168856198 hasConceptScore W2168856198C2777179404 @default.
• W2168856198 hasConceptScore W2168856198C28859421 @default.
• W2168856198 hasConceptScore W2168856198C3675279 @default.
• W2168856198 hasConceptScore W2168856198C501593827 @default.
• W2168856198 hasConceptScore W2168856198C502942594 @default.
• W2168856198 hasConceptScore W2168856198C55493867 @default.
• W2168856198 hasConceptScore W2168856198C57600042 @default.
• W2168856198 hasConceptScore W2168856198C62112901 @default.
• W2168856198 hasConceptScore W2168856198C86803240 @default.
• W2168856198 hasConceptScore W2168856198C95444343 @default.
• W2168856198 hasIssue "7" @default.
• W2168856198 hasLocation W21688561981 @default.
• W2168856198 hasOpenAccess W2168856198 @default.
• W2168856198 hasPrimaryLocation W21688561981 @default.
• W2168856198 hasRelatedWork W136700406 @default.
• W2168856198 hasRelatedWork W1758536049 @default.
• W2168856198 hasRelatedWork W1970761312 @default.
• W2168856198 hasRelatedWork W1976564273 @default.
• W2168856198 hasRelatedWork W2053228778 @default.
• W2168856198 hasRelatedWork W2168856198 @default.
• W2168856198 hasRelatedWork W2328389633 @default.
• W2168856198 hasRelatedWork W2398607903 @default.
• W2168856198 hasRelatedWork W2460277870 @default.
• W2168856198 hasRelatedWork W2464013877 @default.
• W2168856198 hasVolume "46" @default.
• W2168856198 isParatext "false" @default.
• W2168856198 isRetracted "false" @default.
• W2168856198 magId "2168856198" @default.

• next