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- W2168889270 abstract "Zilla Wong and colleagues (April 10, p 1222)1Wong ZYH Stebbing M Ellis JA Lamantia A Harrap SB Genetic linkage of β and γ subunits of epithelial sodium channel to systolic blood pressure.Lancet. 1999; 353: 1222-1225Summary Full Text Full Text PDF PubMed Scopus (62) Google Scholar report an interesting genetic linkage between chromosome 16p12 and systolic blood pressure. However, despite lower mean diastolic blood pressure differences in identical-by-descent allele-sharing siblings versus non-allele-sharing siblings (M*=−16), this difference did not reach significance. A similar finding of linkage with systolic blood pressure, but not diastolic blood pressure, was previously noted on chromosome 8p22.2Wu DA Bu X Warden CH et al.Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.J Clin Invest. 1996; 97: 2111-2118Crossref PubMed Scopus (102) Google Scholar Although physiological reasons for such findings were suggested by Wong, the findings could also be explained statistically. Korotkoff's phases are routinely used in clinical practice to measure blood pressures. However, compared with Korotkoff I for systolic blood pressure, diastolic blood pressure measured manually by Korotkoff V are less precise. Although the clinical significance of this approach is generally negligible, it leads readily to decreased statistical power in quantitative linkage analysis since the variance for within sibling-pair differences is increased. This problem is further confounded by practical difficulties in obtaining an adequate number of families,3Colhoun H Confirmation needed for genes for hypertension.Lancet. 1999; 353: 1200-1201Summary Full Text Full Text PDF PubMed Scopus (12) Google Scholar and the lower total population variance in diastolic compared with that of systolic blood pressure. Therefore, multiple and unbiased blood-pressure readings, such as ambulatory blood pressure monitoring, would be useful in this field of research settings. Blood pressure measurements in genetic linkage studiesAuthors's reply Full-Text PDF" @default.
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- W2168889270 date "1999-06-01" @default.
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- W2168889270 title "Blood pressure measurements in genetic linkage studies" @default.
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- W2168889270 doi "https://doi.org/10.1016/s0140-6736(05)76296-6" @default.
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