FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168891004> ?p ?o ?g. }

• W2168891004 endingPage "F643" @default.
• W2168891004 startingPage "F635" @default.
• W2168891004 abstract "Several xenobiotic (organic cation and anion) transporters have recently been identified, although their endogenous substrates, if such exist, remain unknown. When we initially identified NKT, also known as OAT1, the first member of the organic anion transporter (OAT) family (Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, and Nigam SK. J Biol Chem 272: 6471–6478, 1997), we noted its expression in the embryonic kidney. We have now demonstrated its transporter function and more fully examined the spatiotemporal expression patterns of representative organic ion transporters, [NKT (OAT1), Roct, OCT1, and NLT, also known as OAT2] during murine development. In the kidney, NKT (OAT1), OCT1, and Roct transcripts appeared at midgestation, coinciding with proximal tubule differentiation, and gradually increased during nephron maturation. A similar pattern was observed for NLT (OAT2) in the liver and kidney, although, in the kidney, NLT (OAT2) transcription did not increase as dramatically. The roughly cotemporal expression of these related transporters in the developing proximal tubule may indicate common transcriptional regulation. Expression during embryogenesis in extrarenal sites could suggest a role in the formation and maintenance of nonrenal tissues. Importantly, all four genes were expressed in unexpected places during nonrenal organogenesis: Roct in the fetal liver (temporally coinciding with the onset of hematopoiesis) and neural tissue; NKT (OAT1) in the fetal brain; OCT1 in the ascending aorta and atrium; and NLT (OAT2) in the fetal lung, intestine, skin, and developing bone. Because these gene products mediate the transport of a broad range of metabolites and toxins, it seems likely that, apart from their known functions, these transporters play a role in transport of organic molecules, perhaps including those with morphogenetic activity. These genes could also play important developmental roles independent of transport function." @default.
• W2168891004 created "2016-06-24" @default.
• W2168891004 creator A5022684460 @default.
• W2168891004 creator A5041250587 @default.
• W2168891004 creator A5045237664 @default.
• W2168891004 creator A5048311675 @default.
• W2168891004 creator A5071917165 @default.
• W2168891004 creator A5073565199 @default.
• W2168891004 date "2000-04-01" @default.
• W2168891004 modified "2023-10-07" @default.
• W2168891004 title "Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct" @default.
• W2168891004 cites W1487237607 @default.
• W2168891004 cites W1760881121 @default.
• W2168891004 cites W1977244805 @default.
• W2168891004 cites W1980981920 @default.
• W2168891004 cites W1994024795 @default.
• W2168891004 cites W1996402420 @default.
• W2168891004 cites W2009864409 @default.
• W2168891004 cites W2013547790 @default.
• W2168891004 cites W2022246579 @default.
• W2168891004 cites W2025826061 @default.
• W2168891004 cites W2034122854 @default.
• W2168891004 cites W2038856804 @default.
• W2168891004 cites W2048296585 @default.
• W2168891004 cites W2051989471 @default.
• W2168891004 cites W2067650742 @default.
• W2168891004 cites W2073048087 @default.
• W2168891004 cites W2082188851 @default.
• W2168891004 cites W2143808974 @default.
• W2168891004 cites W2145083626 @default.
• W2168891004 cites W2145869500 @default.
• W2168891004 cites W2313279927 @default.
• W2168891004 cites W4251680621 @default.
• W2168891004 doi "https://doi.org/10.1152/ajprenal.2000.278.4.f635" @default.
• W2168891004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10751225" @default.
• W2168891004 hasPublicationYear "2000" @default.
• W2168891004 type Work @default.
• W2168891004 sameAs 2168891004 @default.
• W2168891004 citedByCount "95" @default.
• W2168891004 countsByYear W21688910042012 @default.
• W2168891004 countsByYear W21688910042013 @default.
• W2168891004 countsByYear W21688910042014 @default.
• W2168891004 countsByYear W21688910042015 @default.
• W2168891004 countsByYear W21688910042016 @default.
• W2168891004 countsByYear W21688910042017 @default.
• W2168891004 countsByYear W21688910042018 @default.
• W2168891004 countsByYear W21688910042019 @default.
• W2168891004 countsByYear W21688910042020 @default.
• W2168891004 countsByYear W21688910042021 @default.
• W2168891004 countsByYear W21688910042022 @default.
• W2168891004 crossrefType "journal-article" @default.
• W2168891004 hasAuthorship W2168891004A5022684460 @default.
• W2168891004 hasAuthorship W2168891004A5041250587 @default.
• W2168891004 hasAuthorship W2168891004A5045237664 @default.
• W2168891004 hasAuthorship W2168891004A5048311675 @default.
• W2168891004 hasAuthorship W2168891004A5071917165 @default.
• W2168891004 hasAuthorship W2168891004A5073565199 @default.
• W2168891004 hasConcept C104317684 @default.
• W2168891004 hasConcept C121421483 @default.
• W2168891004 hasConcept C123584848 @default.
• W2168891004 hasConcept C126322002 @default.
• W2168891004 hasConcept C134018914 @default.
• W2168891004 hasConcept C145148216 @default.
• W2168891004 hasConcept C149011108 @default.
• W2168891004 hasConcept C178790620 @default.
• W2168891004 hasConcept C185592680 @default.
• W2168891004 hasConcept C189613389 @default.
• W2168891004 hasConcept C2780091579 @default.
• W2168891004 hasConcept C55493867 @default.
• W2168891004 hasConcept C71924100 @default.
• W2168891004 hasConcept C86803240 @default.
• W2168891004 hasConceptScore W2168891004C104317684 @default.
• W2168891004 hasConceptScore W2168891004C121421483 @default.
• W2168891004 hasConceptScore W2168891004C123584848 @default.
• W2168891004 hasConceptScore W2168891004C126322002 @default.
• W2168891004 hasConceptScore W2168891004C134018914 @default.
• W2168891004 hasConceptScore W2168891004C145148216 @default.
• W2168891004 hasConceptScore W2168891004C149011108 @default.
• W2168891004 hasConceptScore W2168891004C178790620 @default.
• W2168891004 hasConceptScore W2168891004C185592680 @default.
• W2168891004 hasConceptScore W2168891004C189613389 @default.
• W2168891004 hasConceptScore W2168891004C2780091579 @default.
• W2168891004 hasConceptScore W2168891004C55493867 @default.
• W2168891004 hasConceptScore W2168891004C71924100 @default.
• W2168891004 hasConceptScore W2168891004C86803240 @default.
• W2168891004 hasIssue "4" @default.
• W2168891004 hasLocation W21688910041 @default.
• W2168891004 hasLocation W21688910042 @default.
• W2168891004 hasOpenAccess W2168891004 @default.
• W2168891004 hasPrimaryLocation W21688910041 @default.
• W2168891004 hasRelatedWork W1550259003 @default.
• W2168891004 hasRelatedWork W2052888437 @default.
• W2168891004 hasRelatedWork W2071878521 @default.
• W2168891004 hasRelatedWork W2134077256 @default.
• W2168891004 hasRelatedWork W2152732346 @default.
• W2168891004 hasRelatedWork W2266297952 @default.
• W2168891004 hasRelatedWork W2356415831 @default.
• W2168891004 hasRelatedWork W3194807765 @default.

• next