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• W2168914309 abstract "Trithorax and polycomb group proteins are generally thought to antagonize one another. The trithorax family member MLL (myeloid/lymphoid or mixed-lineage leukemia) is presumed to activate Hox expression, counteracting polycomb-mediated repression. PC4 and SF2 interacting protein 1 (PSIP1)/p75, also known as LEDGF, whose PWWP domain binds to H3K36me3, interacts with MLL and tethers MLL fusion proteins to HOXA9 in leukaemias. Here we show, unexpectedly, that Psip1/p75 regulates homeotic genes by recruiting not only MLL complexes, but also the polycomb group protein Bmi1. In Psip1−/− cells binding of Mll1/2, Bmi1 and the co-repressor Ctbp1 at Hox loci are all abrogated and Hoxa and Hoxd mRNA expression increased. Our data not only reveal a potential mechanism of action for Psip1 in the regulation of Hox genes but also suggest an unexpected interplay between proteins usually considered as transcriptional activators and repressors." @default.
• W2168914309 created "2016-06-24" @default.
• W2168914309 creator A5037856626 @default.
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• W2168914309 creator A5079509111 @default.
• W2168914309 date "2014-07-23" @default.
• W2168914309 modified "2023-10-01" @default.
• W2168914309 title "Psip1/Ledgf p75 restrains<i>Hox</i>gene expression by recruiting both trithorax and polycomb group proteins" @default.
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• W2168914309 doi "https://doi.org/10.1093/nar/gku647" @default.
• W2168914309 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4132756" @default.
• W2168914309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25056311" @default.
• W2168914309 hasPublicationYear "2014" @default.
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