FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168920723> ?p ?o ?g. }

• W2168920723 endingPage "3893" @default.
• W2168920723 startingPage "3886" @default.
• W2168920723 abstract "Abstract Tumor suppressor p53 plays an important role in regulating cell cycle progression and apoptosis. Here we applied RNA interference to study the role of p53 in human hematopoietic development in vivo. An siRNA construct specifically targeting the human tumor-suppressor gene p53 was introduced into human CD34+ progenitor cells by lentivirus-mediated gene transfer, which resulted in more than 95% knockdown of p53. We adapted the human-SCID mouse model to optimize the development of hematopoietic cells, particularly of T cells. This was achieved by the intraperitoneal injection of CD34+ precursor cells into newborn Rag2-/- γc-/- mice that lack T, B, and NK cells. Robust development of T cells was observed in these mice, with peripheral T-cell repopulation 8 weeks after injection of the precursor cells. Other lymphocyte and myeloid subsets also developed in these mice. Injecting p53 siRNA-transduced CD34+ cells resulted in stable expression and down-modulation of p53 in the mature T-cell offspring. Inactivating p53 did not affect the development of CD34+ cells into various mature leukocyte subsets, including T cells, but it conferred resistance to γ-irradiation and other p53-dependent apoptotic stimuli to the T cells. (Blood. 2004;104:3886-3893)" @default.
• W2168920723 created "2016-06-24" @default.
• W2168920723 creator A5001766750 @default.
• W2168920723 creator A5013085782 @default.
• W2168920723 creator A5027997274 @default.
• W2168920723 creator A5032186327 @default.
• W2168920723 creator A5032727410 @default.
• W2168920723 creator A5070460836 @default.
• W2168920723 creator A5078225305 @default.
• W2168920723 creator A5087932335 @default.
• W2168920723 creator A5089955013 @default.
• W2168920723 date "2004-12-15" @default.
• W2168920723 modified "2023-10-18" @default.
• W2168920723 title "Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- γc-/- mice: functional inactivation of p53 in developing T cells" @default.
• W2168920723 cites W1515620844 @default.
• W2168920723 cites W1830776040 @default.
• W2168920723 cites W1966482743 @default.
• W2168920723 cites W1979049274 @default.
• W2168920723 cites W1979751962 @default.
• W2168920723 cites W1995552443 @default.
• W2168920723 cites W2009630518 @default.
• W2168920723 cites W2009886857 @default.
• W2168920723 cites W2014609514 @default.
• W2168920723 cites W2024446294 @default.
• W2168920723 cites W2027122999 @default.
• W2168920723 cites W2038783205 @default.
• W2168920723 cites W2039704215 @default.
• W2168920723 cites W2055349083 @default.
• W2168920723 cites W2063096720 @default.
• W2168920723 cites W2063669247 @default.
• W2168920723 cites W2073489229 @default.
• W2168920723 cites W2076787873 @default.
• W2168920723 cites W2078581194 @default.
• W2168920723 cites W2088672106 @default.
• W2168920723 cites W2089082314 @default.
• W2168920723 cites W2101722758 @default.
• W2168920723 cites W2113300169 @default.
• W2168920723 cites W2120028488 @default.
• W2168920723 cites W2126679757 @default.
• W2168920723 cites W2141714136 @default.
• W2168920723 cites W2146900615 @default.
• W2168920723 cites W2147290688 @default.
• W2168920723 cites W2150990082 @default.
• W2168920723 cites W2167465779 @default.
• W2168920723 cites W2169761717 @default.
• W2168920723 cites W2172228770 @default.
• W2168920723 cites W2315873899 @default.
• W2168920723 cites W2316035294 @default.
• W2168920723 cites W2405246349 @default.
• W2168920723 cites W4211039187 @default.
• W2168920723 cites W4313324526 @default.
• W2168920723 cites W88494872 @default.
• W2168920723 doi "https://doi.org/10.1182/blood-2004-02-0656" @default.
• W2168920723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15319293" @default.
• W2168920723 hasPublicationYear "2004" @default.
• W2168920723 type Work @default.
• W2168920723 sameAs 2168920723 @default.
• W2168920723 citedByCount "179" @default.
• W2168920723 countsByYear W21689207232012 @default.
• W2168920723 countsByYear W21689207232013 @default.
• W2168920723 countsByYear W21689207232014 @default.
• W2168920723 countsByYear W21689207232015 @default.
• W2168920723 countsByYear W21689207232016 @default.
• W2168920723 countsByYear W21689207232017 @default.
• W2168920723 countsByYear W21689207232018 @default.
• W2168920723 countsByYear W21689207232019 @default.
• W2168920723 countsByYear W21689207232020 @default.
• W2168920723 countsByYear W21689207232021 @default.
• W2168920723 countsByYear W21689207232022 @default.
• W2168920723 countsByYear W21689207232023 @default.
• W2168920723 crossrefType "journal-article" @default.
• W2168920723 hasAuthorship W2168920723A5001766750 @default.
• W2168920723 hasAuthorship W2168920723A5013085782 @default.
• W2168920723 hasAuthorship W2168920723A5027997274 @default.
• W2168920723 hasAuthorship W2168920723A5032186327 @default.
• W2168920723 hasAuthorship W2168920723A5032727410 @default.
• W2168920723 hasAuthorship W2168920723A5070460836 @default.
• W2168920723 hasAuthorship W2168920723A5078225305 @default.
• W2168920723 hasAuthorship W2168920723A5087932335 @default.
• W2168920723 hasAuthorship W2168920723A5089955013 @default.
• W2168920723 hasBestOaLocation W21689207231 @default.
• W2168920723 hasConcept C10205521 @default.
• W2168920723 hasConcept C104317684 @default.
• W2168920723 hasConcept C109159458 @default.
• W2168920723 hasConcept C119056186 @default.
• W2168920723 hasConcept C129374314 @default.
• W2168920723 hasConcept C131665280 @default.
• W2168920723 hasConcept C153911025 @default.
• W2168920723 hasConcept C173396325 @default.
• W2168920723 hasConcept C190283241 @default.
• W2168920723 hasConcept C201750760 @default.
• W2168920723 hasConcept C203014093 @default.
• W2168920723 hasConcept C2776090121 @default.
• W2168920723 hasConcept C28328180 @default.
• W2168920723 hasConcept C502942594 @default.
• W2168920723 hasConcept C55493867 @default.
• W2168920723 hasConcept C86803240 @default.
• W2168920723 hasConcept C8891405 @default.

• next