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- W2168940143 abstract "The immunotoxic effect of the herbicide chloridazone was evaluated on the basis of the metabolic activity of phagocytes and mitogenic activation of lymphocytes. In sheep exposed to a single acute dose of 80 mg/kg body weight (1/2 LD 50) and metabolic activity of phagocytes, migration index of leukocytes and haematological parameters have been investigated at 6, 12, 24 h after ingestion. The significant increase of metabolic activity of peripheral blood phagocytes was registered at 12 h (P < 0.01) and the activation of lymphocytes by phytohaemaggl utinin significantly decreased (P < 0.01) at 24 h of intoxication. Haemoglobin concentration and haematocrit were significantly decreased at 6, 12 h with the maximum fall at 24 h (P < 0.05). No significant changes in the numbers of erythrocytes, leukocytes, mean corpuscular volume as well as differential blood count were observed. In in vitro experiment chloridazone was tested at the concentrations of 10 -1 – 10 -6 M. At these concentrations of chloridazone the mild non-significant decrease in the functional activity of phagocytes was detected. The significant cytotoxic effect (the decrease in spontaneous migration of leukocytes) was registered at the concentrations of 10 -1 M (P < 0.001) and 10 -2 M (P < 0.05). The differences in the effect of the herbicide under in vivo and in vitro conditions suggest that the indirect immunotoxic effect of chloridazone results from its hepatotoxic effect." @default.
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- W2168940143 date "2003-01-01" @default.
- W2168940143 modified "2023-09-30" @default.
- W2168940143 title "Influence of herbicide chloridazone on haematological parameters and functional activity of leucocytes in sheep" @default.
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