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- W2168942291 abstract "High mobility group box 1 protein (HMGB1) is a chromatin protein that has a dual function as a nuclear factor and as an extracellular factor. Extracellular HMGB1 released by damaged cells acts as a chemoattractant, as well as a proinflammatory cytokine, suggesting that HMGB1 is tightly connected to the process of tissue organization. However, the role of HMGB1 in bone and cartilage that undergo remodeling during embryogenesis, tissue repair, and disease is largely unknown. We show here that the stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. We analyzed the skeletal development of Hmgb1−/− mice during embryogenesis and found that endochondral ossification is significantly impaired due to the delay of cartilage invasion by osteoclasts, osteoblasts, and blood vessels. Immunohistochemical analysis revealed that HMGB1 protein accumulated in the cytosol of hypertrophic chondrocytes at growth plates, and its extracellular release from the chondrocytes was verified by organ culture. Furthermore, we demonstrated that the chondrocyte-secreted HMGB1 functions as a chemoattractant for osteoclasts and osteoblasts, as well as for endothelial cells, further supporting the conclusion that Hmgb1−/− mice are defective in cell invasion. Collectively, these findings suggest that HMGB1 released from differentiating chondrocytes acts, at least in part, as a regulator of endochondral ossification during osteogenesis." @default.
- W2168942291 created "2016-06-24" @default.
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- W2168942291 date "2007-08-01" @default.
- W2168942291 modified "2023-10-18" @default.
- W2168942291 title "Stage-Specific Secretion of HMGB1 in Cartilage Regulates Endochondral Ossification" @default.
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- W2168942291 cites W1953148896 @default.
- W2168942291 cites W1971551127 @default.
- W2168942291 cites W1977962646 @default.
- W2168942291 cites W1981399177 @default.
- W2168942291 cites W1990665236 @default.
- W2168942291 cites W1994190235 @default.
- W2168942291 cites W1995499476 @default.
- W2168942291 cites W1997812904 @default.
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- W2168942291 cites W2029068688 @default.
- W2168942291 cites W2036374720 @default.
- W2168942291 cites W2050488981 @default.
- W2168942291 cites W2058565815 @default.
- W2168942291 cites W2061163173 @default.
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- W2168942291 doi "https://doi.org/10.1128/mcb.00130-07" @default.
- W2168942291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1952123" @default.
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