FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168946432> ?p ?o ?g. }

• W2168946432 endingPage "2571" @default.
• W2168946432 startingPage "2563" @default.
• W2168946432 abstract "The plasma membrane Ca 2+ ATPase (PMCA) plays a major role in restoring Ca 2+ to basal levels following transient elevation by neuronal activity. Here we examined the effects of various stimuli that increase [Ca 2+ ] i on PMCA-mediated Ca 2+ clearance from hippocampal neurons. We used indo-1-based microfluorimetry in the presence of cyclopiazonic acid to study the rate of PMCA-mediated recovery of Ca 2+ elevated by a brief train of action potentials. [Ca 2+ ] i recovery was described by an exponential decay and the time constant provided an index of PMCA-mediated Ca 2+ clearance. PMCA function was assessed before and for ≥60 min following a 10-min priming stimulus of either 100 μM N-methyl-d-aspartate (NMDA), 0.1 mM Mg 2+ (reduced extracellular Mg 2+ induces intense excitatory synaptic activity), 30 mM K + , or control buffer. Recovery kinetics slowed progressively following priming with NMDA or 0.1 mM Mg 2+ ; in contrast, Ca 2+ clearance initially accelerated and then slowly returned to initial rates following priming with 30 mM K + -induced depolarization. Treatment with 10 μM calpeptin, an inhibitor of the Ca 2+ activated protease calpain, prevented the slowing of kinetics observed following treatment with NMDA but had no affect on the recovery kinetics of control cells. Calpeptin also blocked the rapid acceleration of Ca 2+ clearance following depolarization. In calpeptin-treated cells, 0.1 mM Mg 2+ induced a graded acceleration of Ca 2+ clearance. Thus in spite of producing comparable increases in [Ca 2+ ] i , activation of NMDA receptors, depolarization-induced activation of voltage-gated Ca 2+ channels and excitatory synaptic activity each uniquely affected Ca 2+ clearance kinetics mediated by the PMCA." @default.
• W2168946432 created "2016-06-24" @default.
• W2168946432 creator A5037002798 @default.
• W2168946432 creator A5038294089 @default.
• W2168946432 creator A5082049932 @default.
• W2168946432 date "2009-05-01" @default.
• W2168946432 modified "2023-09-29" @default.
• W2168946432 title "Ca²⁺-Dependent, Stimulus-Specific Modulation of the Plasma Membrane Ca²⁺Pump in Hippocampal Neurons" @default.
• W2168946432 cites W1513600037 @default.
• W2168946432 cites W1519184577 @default.
• W2168946432 cites W1557236506 @default.
• W2168946432 cites W1574112238 @default.
• W2168946432 cites W1603617892 @default.
• W2168946432 cites W1648000881 @default.
• W2168946432 cites W1878905851 @default.
• W2168946432 cites W1920445018 @default.
• W2168946432 cites W1938878737 @default.
• W2168946432 cites W1953600165 @default.
• W2168946432 cites W1976674321 @default.
• W2168946432 cites W1978069452 @default.
• W2168946432 cites W1993385893 @default.
• W2168946432 cites W2002027111 @default.
• W2168946432 cites W2002044194 @default.
• W2168946432 cites W2007346353 @default.
• W2168946432 cites W2020506420 @default.
• W2168946432 cites W2021235911 @default.
• W2168946432 cites W2025764899 @default.
• W2168946432 cites W2028664196 @default.
• W2168946432 cites W2029829082 @default.
• W2168946432 cites W2034526004 @default.
• W2168946432 cites W2043857209 @default.
• W2168946432 cites W204475490 @default.
• W2168946432 cites W2068748170 @default.
• W2168946432 cites W2069227664 @default.
• W2168946432 cites W2070052866 @default.
• W2168946432 cites W2072565124 @default.
• W2168946432 cites W2078713240 @default.
• W2168946432 cites W2085180836 @default.
• W2168946432 cites W2107321441 @default.
• W2168946432 cites W2129034648 @default.
• W2168946432 cites W2140298693 @default.
• W2168946432 cites W2141260882 @default.
• W2168946432 cites W2146319595 @default.
• W2168946432 cites W2148999943 @default.
• W2168946432 cites W2153060249 @default.
• W2168946432 cites W2169436026 @default.
• W2168946432 cites W2170617433 @default.
• W2168946432 cites W2174925893 @default.
• W2168946432 cites W2239360134 @default.
• W2168946432 cites W340599019 @default.
• W2168946432 cites W43853842 @default.
• W2168946432 doi "https://doi.org/10.1152/jn.90774.2008" @default.
• W2168946432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2681429" @default.
• W2168946432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19244356" @default.
• W2168946432 hasPublicationYear "2009" @default.
• W2168946432 type Work @default.
• W2168946432 sameAs 2168946432 @default.
• W2168946432 citedByCount "10" @default.
• W2168946432 countsByYear W21689464322012 @default.
• W2168946432 countsByYear W21689464322015 @default.
• W2168946432 countsByYear W21689464322017 @default.
• W2168946432 countsByYear W21689464322018 @default.
• W2168946432 countsByYear W21689464322022 @default.
• W2168946432 countsByYear W21689464322023 @default.
• W2168946432 crossrefType "journal-article" @default.
• W2168946432 hasAuthorship W2168946432A5037002798 @default.
• W2168946432 hasAuthorship W2168946432A5038294089 @default.
• W2168946432 hasAuthorship W2168946432A5082049932 @default.
• W2168946432 hasBestOaLocation W21689464322 @default.
• W2168946432 hasConcept C112592302 @default.
• W2168946432 hasConcept C12554922 @default.
• W2168946432 hasConcept C126322002 @default.
• W2168946432 hasConcept C134018914 @default.
• W2168946432 hasConcept C148762608 @default.
• W2168946432 hasConcept C170493617 @default.
• W2168946432 hasConcept C185592680 @default.
• W2168946432 hasConcept C2779996123 @default.
• W2168946432 hasConcept C28406088 @default.
• W2168946432 hasConcept C4141045 @default.
• W2168946432 hasConcept C55493867 @default.
• W2168946432 hasConcept C67018056 @default.
• W2168946432 hasConcept C71924100 @default.
• W2168946432 hasConcept C79879829 @default.
• W2168946432 hasConcept C86803240 @default.
• W2168946432 hasConceptScore W2168946432C112592302 @default.
• W2168946432 hasConceptScore W2168946432C12554922 @default.
• W2168946432 hasConceptScore W2168946432C126322002 @default.
• W2168946432 hasConceptScore W2168946432C134018914 @default.
• W2168946432 hasConceptScore W2168946432C148762608 @default.
• W2168946432 hasConceptScore W2168946432C170493617 @default.
• W2168946432 hasConceptScore W2168946432C185592680 @default.
• W2168946432 hasConceptScore W2168946432C2779996123 @default.
• W2168946432 hasConceptScore W2168946432C28406088 @default.
• W2168946432 hasConceptScore W2168946432C4141045 @default.
• W2168946432 hasConceptScore W2168946432C55493867 @default.
• W2168946432 hasConceptScore W2168946432C67018056 @default.
• W2168946432 hasConceptScore W2168946432C71924100 @default.
• W2168946432 hasConceptScore W2168946432C79879829 @default.

• next