Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168973724> ?p ?o ?g. }
- W2168973724 endingPage "11" @default.
- W2168973724 startingPage "2" @default.
- W2168973724 abstract "We will take a journey from basic pathogenetic mechanisms elicited by viral infections that play a role in the development of type 1 diabetes to clinical interventions, where we will discuss novel combination therapies. The role of viral infections in the development of type 1 diabetes is a rather interesting topic because in experimental models viruses appear capable of both accelerating as well as decelerating the immunological processes leading to type 1 diabetes. Consequently, I will discuss some of the underlying mechanisms for each situation and consider methods to investigate the proposed dichotomy for the involvement of viruses in human type 1 diabetes. Prevention of type 1 diabetes by infection supports the so-called hygiene hypothesis. Interestingly, viruses invoke mechanisms that need to be exploited by novel combinatorial immune-based interventions, the first one being the elimination of autoaggressive T-cells attacking the beta-cells, ultimately leading to their immediate but temporally limited amelioration. The other is the invigoration of regulatory T-cells (Tregs), which can mediate long-term tolerance to beta-cell proteins in the pancreatic islets and draining lymph nodes. In combination, these two immune elements have the potential to permanently stop type 1 diabetes. It is my belief that only combination therapies will enable the permanent prevention and curing of type 1 diabetes." @default.
- W2168973724 created "2016-06-24" @default.
- W2168973724 creator A5037699464 @default.
- W2168973724 date "2009-01-01" @default.
- W2168973724 modified "2023-10-13" @default.
- W2168973724 title "Can We Learn From Viruses How to Prevent Type 1 Diabetes?" @default.
- W2168973724 cites W1486125213 @default.
- W2168973724 cites W1521576648 @default.
- W2168973724 cites W1546831560 @default.
- W2168973724 cites W1556377955 @default.
- W2168973724 cites W1802879891 @default.
- W2168973724 cites W1806633029 @default.
- W2168973724 cites W1856161448 @default.
- W2168973724 cites W1963770029 @default.
- W2168973724 cites W1963917815 @default.
- W2168973724 cites W1969795555 @default.
- W2168973724 cites W1970021680 @default.
- W2168973724 cites W1973848837 @default.
- W2168973724 cites W1976986053 @default.
- W2168973724 cites W1981191760 @default.
- W2168973724 cites W1981374189 @default.
- W2168973724 cites W1984860462 @default.
- W2168973724 cites W1986256137 @default.
- W2168973724 cites W1997948740 @default.
- W2168973724 cites W2002105288 @default.
- W2168973724 cites W2014333565 @default.
- W2168973724 cites W2017186381 @default.
- W2168973724 cites W2017622199 @default.
- W2168973724 cites W2017655712 @default.
- W2168973724 cites W2028174844 @default.
- W2168973724 cites W2034306860 @default.
- W2168973724 cites W2042321461 @default.
- W2168973724 cites W2043204562 @default.
- W2168973724 cites W2044226569 @default.
- W2168973724 cites W2053929946 @default.
- W2168973724 cites W2057328452 @default.
- W2168973724 cites W2064847390 @default.
- W2168973724 cites W2068911825 @default.
- W2168973724 cites W2071448249 @default.
- W2168973724 cites W2075906129 @default.
- W2168973724 cites W2086367603 @default.
- W2168973724 cites W2086848645 @default.
- W2168973724 cites W2087830003 @default.
- W2168973724 cites W2115785387 @default.
- W2168973724 cites W2118970732 @default.
- W2168973724 cites W2119249252 @default.
- W2168973724 cites W2133576690 @default.
- W2168973724 cites W2135280067 @default.
- W2168973724 cites W2139235644 @default.
- W2168973724 cites W2142232563 @default.
- W2168973724 cites W2146664729 @default.
- W2168973724 cites W2149513114 @default.
- W2168973724 cites W2160738923 @default.
- W2168973724 cites W2161817457 @default.
- W2168973724 cites W2162675860 @default.
- W2168973724 cites W2164701887 @default.
- W2168973724 cites W2167304816 @default.
- W2168973724 cites W2170412426 @default.
- W2168973724 cites W2170484885 @default.
- W2168973724 cites W2331003380 @default.
- W2168973724 cites W4322385180 @default.
- W2168973724 cites W1973768996 @default.
- W2168973724 cites W2030830816 @default.
- W2168973724 cites W2064068901 @default.
- W2168973724 doi "https://doi.org/10.2337/db08-9027" @default.
- W2168973724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2606872" @default.
- W2168973724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19114721" @default.
- W2168973724 hasPublicationYear "2009" @default.
- W2168973724 type Work @default.
- W2168973724 sameAs 2168973724 @default.
- W2168973724 citedByCount "52" @default.
- W2168973724 countsByYear W21689737242012 @default.
- W2168973724 countsByYear W21689737242013 @default.
- W2168973724 countsByYear W21689737242014 @default.
- W2168973724 countsByYear W21689737242015 @default.
- W2168973724 countsByYear W21689737242016 @default.
- W2168973724 countsByYear W21689737242017 @default.
- W2168973724 countsByYear W21689737242018 @default.
- W2168973724 countsByYear W21689737242021 @default.
- W2168973724 countsByYear W21689737242022 @default.
- W2168973724 crossrefType "journal-article" @default.
- W2168973724 hasAuthorship W2168973724A5037699464 @default.
- W2168973724 hasBestOaLocation W21689737241 @default.
- W2168973724 hasConcept C118552586 @default.
- W2168973724 hasConcept C134018914 @default.
- W2168973724 hasConcept C165220095 @default.
- W2168973724 hasConcept C203014093 @default.
- W2168973724 hasConcept C27415008 @default.
- W2168973724 hasConcept C2776828364 @default.
- W2168973724 hasConcept C2777180221 @default.
- W2168973724 hasConcept C2779855799 @default.
- W2168973724 hasConcept C2781232474 @default.
- W2168973724 hasConcept C555293320 @default.
- W2168973724 hasConcept C60644358 @default.
- W2168973724 hasConcept C71924100 @default.
- W2168973724 hasConcept C86803240 @default.
- W2168973724 hasConcept C8891405 @default.
- W2168973724 hasConceptScore W2168973724C118552586 @default.