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• W2168980816 startingPage "25" @default.
• W2168980816 abstract "The overall DNA methylation level sharply decreases from the zygote to the blastocyst stage despite the presence of high levels of DNA methyltransferase (Dnmt1). Surprisingly, the enzyme is localized in the cytoplasm of early embryos despite the presence of several functional nuclear localization signals. We mapped a region in the NH(2)-terminal, regulatory domain of Dnmt1 that is necessary and sufficient for cytoplasmic retention during early development. Altogether, our results suggest that Dnmt1 is actively retained in the cytoplasm, which prevents binding to its DNA substrate in the nucleus and thereby contributes to the erasure of gamete-specific epigenetic information during early mammalian development." @default.
• W2168980816 created "2016-06-24" @default.
• W2168980816 creator A5031935199 @default.
• W2168980816 creator A5033605271 @default.
• W2168980816 date "1999-10-04" @default.
• W2168980816 modified "2023-10-17" @default.
• W2168980816 title "DNA Methyltransferase Is Actively Retained in the Cytoplasm during Early Development" @default.
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• W2168980816 doi "https://doi.org/10.1083/jcb.147.1.25" @default.
• W2168980816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2164986" @default.
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• W2168980816 hasPublicationYear "1999" @default.
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