Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168986165> ?p ?o ?g. }
- W2168986165 endingPage "G955" @default.
- W2168986165 startingPage "G950" @default.
- W2168986165 abstract "Fibrosis is characterized by excessive accumulation of collagen and other extracellular matrix (ECM) components, and this process has been likened to aberrant wound healing. The early phases of wound healing involve the formation of a provisional ECM containing fibrin, fibrinogen, and fibronectin. Fibroblasts occupy this matrix and proliferate in response to activators elaborated by leukocytes that have migrated into the wound and are retained by the ECM. This coincides with the appearance of the myofibroblast, a specialized form of fibroblast whose differentiation is primarily driven by cytokines, such as transforming growth factor-β (TGF-β), and by mechanical tension. When these signals are reduced, as when TGF-β secretion is reduced, or as in scar shrinkage, myofibroblasts undergo apoptosis, resulting in a collagen-rich, cell-poor scar. Retention of myofibroblasts in fibrosis has been described as the result of imbalanced cytokine signaling, especially with respect to levels of activated TGF-β. ECM components can regulate myofibroblast persistence directly, since this phenotype is dependent on extracellular hyaluronan, tenascin-C, and the fibronectin splice variant containing the “extra domain A,” and also, indirectly, through retention of TGF-β-secreting cells such as eosinophils. Thus the ECM is actively involved in both cellular and extracellular events that lead to fibrosis. Targeting components of the ECM as cells respond to injury and inflammatory stimuli holds promise as a means to avoid development of fibrosis and direct the wound-healing process toward reestablishment of a healthy equilibrium." @default.
- W2168986165 created "2016-06-24" @default.
- W2168986165 creator A5001550520 @default.
- W2168986165 creator A5035268339 @default.
- W2168986165 date "2011-12-01" @default.
- W2168986165 modified "2023-10-16" @default.
- W2168986165 title "The extracellular matrix: an active or passive player in fibrosis?" @default.
- W2168986165 cites W1543809841 @default.
- W2168986165 cites W1562884473 @default.
- W2168986165 cites W1605041458 @default.
- W2168986165 cites W1683802707 @default.
- W2168986165 cites W1690718176 @default.
- W2168986165 cites W1888487585 @default.
- W2168986165 cites W1973895231 @default.
- W2168986165 cites W1975615180 @default.
- W2168986165 cites W1980325398 @default.
- W2168986165 cites W1981269419 @default.
- W2168986165 cites W1982815250 @default.
- W2168986165 cites W1983281361 @default.
- W2168986165 cites W1987492687 @default.
- W2168986165 cites W1988349464 @default.
- W2168986165 cites W1988527057 @default.
- W2168986165 cites W1990917414 @default.
- W2168986165 cites W1992565802 @default.
- W2168986165 cites W1992635362 @default.
- W2168986165 cites W1994823840 @default.
- W2168986165 cites W1998289520 @default.
- W2168986165 cites W2000655121 @default.
- W2168986165 cites W2009117970 @default.
- W2168986165 cites W2009668180 @default.
- W2168986165 cites W2010427736 @default.
- W2168986165 cites W2016193552 @default.
- W2168986165 cites W2018128871 @default.
- W2168986165 cites W2019268059 @default.
- W2168986165 cites W2023345723 @default.
- W2168986165 cites W2027015790 @default.
- W2168986165 cites W2030295847 @default.
- W2168986165 cites W2035391762 @default.
- W2168986165 cites W2042760078 @default.
- W2168986165 cites W2043958179 @default.
- W2168986165 cites W2044855262 @default.
- W2168986165 cites W2048353858 @default.
- W2168986165 cites W2050921789 @default.
- W2168986165 cites W2051696368 @default.
- W2168986165 cites W2052256352 @default.
- W2168986165 cites W2052965509 @default.
- W2168986165 cites W2058488557 @default.
- W2168986165 cites W2060004314 @default.
- W2168986165 cites W2060474417 @default.
- W2168986165 cites W2061582963 @default.
- W2168986165 cites W2076486888 @default.
- W2168986165 cites W2077833316 @default.
- W2168986165 cites W2080982503 @default.
- W2168986165 cites W2094007386 @default.
- W2168986165 cites W2100582120 @default.
- W2168986165 cites W2104002363 @default.
- W2168986165 cites W2109935448 @default.
- W2168986165 cites W2113320375 @default.
- W2168986165 cites W2118121278 @default.
- W2168986165 cites W2118875207 @default.
- W2168986165 cites W2123387934 @default.
- W2168986165 cites W2126011452 @default.
- W2168986165 cites W2127172916 @default.
- W2168986165 cites W2130454566 @default.
- W2168986165 cites W2132262423 @default.
- W2168986165 cites W2134007677 @default.
- W2168986165 cites W2134437854 @default.
- W2168986165 cites W2136418621 @default.
- W2168986165 cites W2143202985 @default.
- W2168986165 cites W2146906769 @default.
- W2168986165 cites W2151381771 @default.
- W2168986165 cites W2153315863 @default.
- W2168986165 cites W2154344982 @default.
- W2168986165 cites W2158287992 @default.
- W2168986165 cites W2162884347 @default.
- W2168986165 cites W2168763646 @default.
- W2168986165 cites W2171909876 @default.
- W2168986165 cites W4210435283 @default.
- W2168986165 doi "https://doi.org/10.1152/ajpgi.00132.2011" @default.
- W2168986165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3233785" @default.
- W2168986165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21512158" @default.
- W2168986165 hasPublicationYear "2011" @default.
- W2168986165 type Work @default.
- W2168986165 sameAs 2168986165 @default.
- W2168986165 citedByCount "290" @default.
- W2168986165 countsByYear W21689861652012 @default.
- W2168986165 countsByYear W21689861652013 @default.
- W2168986165 countsByYear W21689861652014 @default.
- W2168986165 countsByYear W21689861652015 @default.
- W2168986165 countsByYear W21689861652016 @default.
- W2168986165 countsByYear W21689861652017 @default.
- W2168986165 countsByYear W21689861652018 @default.
- W2168986165 countsByYear W21689861652019 @default.
- W2168986165 countsByYear W21689861652020 @default.
- W2168986165 countsByYear W21689861652021 @default.
- W2168986165 countsByYear W21689861652022 @default.
- W2168986165 countsByYear W21689861652023 @default.
- W2168986165 crossrefType "journal-article" @default.