FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168995747> ?p ?o ?g. }

• W2168995747 endingPage "104" @default.
• W2168995747 startingPage "95" @default.
• W2168995747 abstract "Interleukin-12 (IL-12) and IL-23 (which share a p40 subunit) are pivotal cytokines in the generation of protective Th1/Th17-type immune responses upon infection with the intracellular pathogen Mycobacterium tuberculosis. The role of IL-12 and IL-23 in protection conferred by the tuberculosis vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) is, however, less well documented. By using an autovaccine approach, i.e., IL-12p70 cross-linked with ovalbumin and PADRE peptide formulated with the GSK proprietary adjuvant system AS02(V), we could specifically neutralize IL-12 while leaving the IL-23 axis intact. Neutralization of IL-12 before M. tuberculosis challenge rendered C57BL/6 mice highly susceptible, resulting in 30-fold-higher CFU in spleen and lungs and accelerated mortality. In contrast, neutralization of IL-12 in BCG-vaccinated mice prior to M. tuberculosis challenge only marginally affected vaccine-mediated protection. Analysis of cytokine production in spleen and lungs 3 weeks post-TB challenge by enzyme-linked immunosorbent assay and functional and flow cytometric assays showed significantly reduced mycobacterium-specific gamma interferon (IFN-γ) responses in M. tuberculosis-infected and BCG-vaccinated mice that had been treated with the autovaccine. Purified protein derivative-induced tumor necrosis factor alpha (TNF-α), IL-6, and IL-17A levels, however, were highest in lungs from BCG-vaccinated/IL-12-neutralized animals, and even unstimulated lung cells from these mice produced significant levels of the three cytokines. Mycobacterium-specific IL-4 and IL-5 production levels were overall very low, but IL-12 neutralization resulted in increased concanavalin A-triggered polyclonal secretion of these Th2-type cytokines. These results suggest that TNF-α, IL-6, and IL-17A may be more important pulmonary effector molecules of BCG-mediated protection than IFN-γ in a context of IL-12 deficiency." @default.
• W2168995747 created "2016-06-24" @default.
• W2168995747 creator A5007716498 @default.
• W2168995747 creator A5021028530 @default.
• W2168995747 creator A5045879589 @default.
• W2168995747 creator A5047585572 @default.
• W2168995747 creator A5059160872 @default.
• W2168995747 creator A5059525483 @default.
• W2168995747 creator A5085061167 @default.
• W2168995747 date "2011-01-01" @default.
• W2168995747 modified "2023-10-18" @default.
• W2168995747 title "Increased Pulmonary Tumor Necrosis Factor Alpha, Interleukin-6 (IL-6), and IL-17A Responses Compensate for Decreased Gamma Interferon Production in Anti-IL-12 Autovaccine-Treated,<i>Mycobacterium bovis</i>BCG-Vaccinated Mice" @default.
• W2168995747 cites W1506273507 @default.
• W2168995747 cites W1535307867 @default.
• W2168995747 cites W1553227656 @default.
• W2168995747 cites W1623924764 @default.
• W2168995747 cites W1741119320 @default.
• W2168995747 cites W1765079284 @default.
• W2168995747 cites W1786795173 @default.
• W2168995747 cites W1847326477 @default.
• W2168995747 cites W1955441978 @default.
• W2168995747 cites W1969411212 @default.
• W2168995747 cites W1982752226 @default.
• W2168995747 cites W1982794340 @default.
• W2168995747 cites W2031086429 @default.
• W2168995747 cites W2032537032 @default.
• W2168995747 cites W2035261951 @default.
• W2168995747 cites W2038535814 @default.
• W2168995747 cites W2064484362 @default.
• W2168995747 cites W2065791817 @default.
• W2168995747 cites W2071109139 @default.
• W2168995747 cites W2080368732 @default.
• W2168995747 cites W2088654830 @default.
• W2168995747 cites W2090197666 @default.
• W2168995747 cites W2102774054 @default.
• W2168995747 cites W2103425201 @default.
• W2168995747 cites W2105031128 @default.
• W2168995747 cites W2107876252 @default.
• W2168995747 cites W2109484445 @default.
• W2168995747 cites W2109666345 @default.
• W2168995747 cites W2112866067 @default.
• W2168995747 cites W2126092306 @default.
• W2168995747 cites W2134990166 @default.
• W2168995747 cites W2141086773 @default.
• W2168995747 cites W2144005760 @default.
• W2168995747 cites W2149264611 @default.
• W2168995747 cites W2151738661 @default.
• W2168995747 cites W2152994600 @default.
• W2168995747 cites W2159514831 @default.
• W2168995747 cites W2160258620 @default.
• W2168995747 cites W2165508954 @default.
• W2168995747 cites W2171231066 @default.
• W2168995747 doi "https://doi.org/10.1128/cvi.00352-10" @default.
• W2168995747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3019790" @default.
• W2168995747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21084465" @default.
• W2168995747 hasPublicationYear "2011" @default.
• W2168995747 type Work @default.
• W2168995747 sameAs 2168995747 @default.
• W2168995747 citedByCount "19" @default.
• W2168995747 countsByYear W21689957472012 @default.
• W2168995747 countsByYear W21689957472013 @default.
• W2168995747 countsByYear W21689957472014 @default.
• W2168995747 countsByYear W21689957472016 @default.
• W2168995747 countsByYear W21689957472018 @default.
• W2168995747 countsByYear W21689957472020 @default.
• W2168995747 countsByYear W21689957472021 @default.
• W2168995747 crossrefType "journal-article" @default.
• W2168995747 hasAuthorship W2168995747A5007716498 @default.
• W2168995747 hasAuthorship W2168995747A5021028530 @default.
• W2168995747 hasAuthorship W2168995747A5045879589 @default.
• W2168995747 hasAuthorship W2168995747A5047585572 @default.
• W2168995747 hasAuthorship W2168995747A5059160872 @default.
• W2168995747 hasAuthorship W2168995747A5059525483 @default.
• W2168995747 hasAuthorship W2168995747A5085061167 @default.
• W2168995747 hasBestOaLocation W21689957471 @default.
• W2168995747 hasConcept C142724271 @default.
• W2168995747 hasConcept C149532602 @default.
• W2168995747 hasConcept C154317977 @default.
• W2168995747 hasConcept C159047783 @default.
• W2168995747 hasConcept C17991360 @default.
• W2168995747 hasConcept C202751555 @default.
• W2168995747 hasConcept C203014093 @default.
• W2168995747 hasConcept C22070199 @default.
• W2168995747 hasConcept C2777863537 @default.
• W2168995747 hasConcept C2777975735 @default.
• W2168995747 hasConcept C2778288313 @default.
• W2168995747 hasConcept C2778497218 @default.
• W2168995747 hasConcept C2778690821 @default.
• W2168995747 hasConcept C2780841837 @default.
• W2168995747 hasConcept C2780931953 @default.
• W2168995747 hasConcept C2781069245 @default.
• W2168995747 hasConcept C55493867 @default.
• W2168995747 hasConcept C71924100 @default.
• W2168995747 hasConcept C86803240 @default.
• W2168995747 hasConcept C8891405 @default.
• W2168995747 hasConcept C89423630 @default.
• W2168995747 hasConceptScore W2168995747C142724271 @default.
• W2168995747 hasConceptScore W2168995747C149532602 @default.

• next