FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168996635> ?p ?o ?g. }

• W2168996635 endingPage "284" @default.
• W2168996635 startingPage "278" @default.
• W2168996635 abstract "Transient receptor potential (TRP) channels are expressed in cardiomyocytes, which gate a type of influx of extracellular calcium, the capacitative calcium entry. TRP channels play a role in mediating Ca(2+) overload in the heart. Calcium-sensing receptors (CaR) are also expressed in rat cardiac tissue and promote the apoptosis of cardiomyocytes by Ca(2+) overload. However, data about the link between CaR and TRP channels in rat heart are few. In this study, reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting were used to examine the expression of the TRP canonical proteins TRPC1 and TRPC3 in adult and neonatal rat cardiomyocytes. Laser scan confocal microscopy was used to detect intracellular [Ca(2+)](i) levels in isolated adult rat ventricular myocytes. The results showed that, in adult rat cardiomyocytes, the depletion of Ca(2+) stores in the endoplasmic/sarcoplasmic reticulum (ER/SR) by thapsigargin induced a transient increase in [Ca(2+)](i) in the absence of [Ca(2+)](o) and the subsequent restoration of [Ca(2+)](o) sustained the increased [Ca(2+)](i) for a few minutes, whereas, the persisting elevation of [Ca(2+)](i) was reduced in the presence of the TRPC inhibitor SKF96365. The stimulation of CaR by its activator gadolinium chloride (GdCl(3)) or spermine also resulted in the same effect and the duration of [Ca(2+)](i) increase was also shortened in the absence of [Ca(2+)](o). In adult and neonatal rat cardiomyocytes, GdCl(3) increased the expression of TRPC3 mRNA and protein, which were reversed by SKF96365 but not by inhibitors of the L-type channels and the Na(+)/Ca(2+) exchangers. However, GdCl(3) had no obvious effect on the expression of TRPC1 protein. These results suggested that CaR stimulation induced activation of TRP channels and promoted the expression of TRPC3, but not TRPC1, that sustained the increased [Ca(2+)](i)." @default.
• W2168996635 created "2016-06-24" @default.
• W2168996635 creator A5006544399 @default.
• W2168996635 creator A5010907733 @default.
• W2168996635 creator A5031258939 @default.
• W2168996635 creator A5061396145 @default.
• W2168996635 creator A5084688862 @default.
• W2168996635 creator A5088319695 @default.
• W2168996635 date "2011-03-01" @default.
• W2168996635 modified "2023-09-27" @default.
• W2168996635 title "Activation of calcium-sensing receptor increases TRPC3 expression in rat cardiomyocytes" @default.
• W2168996635 cites W1584196799 @default.
• W2168996635 cites W1967411995 @default.
• W2168996635 cites W1972589601 @default.
• W2168996635 cites W1976761947 @default.
• W2168996635 cites W1986866353 @default.
• W2168996635 cites W1993536160 @default.
• W2168996635 cites W2002372547 @default.
• W2168996635 cites W2026101429 @default.
• W2168996635 cites W2027746506 @default.
• W2168996635 cites W2028228064 @default.
• W2168996635 cites W2033743682 @default.
• W2168996635 cites W2038142591 @default.
• W2168996635 cites W2041506959 @default.
• W2168996635 cites W2053261401 @default.
• W2168996635 cites W2058919936 @default.
• W2168996635 cites W2062104253 @default.
• W2168996635 cites W2066598065 @default.
• W2168996635 cites W2128322695 @default.
• W2168996635 cites W2134597348 @default.
• W2168996635 cites W2137258759 @default.
• W2168996635 cites W2146011377 @default.
• W2168996635 cites W2146684396 @default.
• W2168996635 cites W2159587866 @default.
• W2168996635 cites W2170347547 @default.
• W2168996635 cites W2235624762 @default.
• W2168996635 doi "https://doi.org/10.1016/j.bbrc.2011.02.033" @default.
• W2168996635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21316341" @default.
• W2168996635 hasPublicationYear "2011" @default.
• W2168996635 type Work @default.
• W2168996635 sameAs 2168996635 @default.
• W2168996635 citedByCount "20" @default.
• W2168996635 countsByYear W21689966352012 @default.
• W2168996635 countsByYear W21689966352013 @default.
• W2168996635 countsByYear W21689966352014 @default.
• W2168996635 countsByYear W21689966352015 @default.
• W2168996635 countsByYear W21689966352016 @default.
• W2168996635 countsByYear W21689966352017 @default.
• W2168996635 countsByYear W21689966352018 @default.
• W2168996635 countsByYear W21689966352019 @default.
• W2168996635 countsByYear W21689966352020 @default.
• W2168996635 crossrefType "journal-article" @default.
• W2168996635 hasAuthorship W2168996635A5006544399 @default.
• W2168996635 hasAuthorship W2168996635A5010907733 @default.
• W2168996635 hasAuthorship W2168996635A5031258939 @default.
• W2168996635 hasAuthorship W2168996635A5061396145 @default.
• W2168996635 hasAuthorship W2168996635A5084688862 @default.
• W2168996635 hasAuthorship W2168996635A5088319695 @default.
• W2168996635 hasConcept C113217602 @default.
• W2168996635 hasConcept C126322002 @default.
• W2168996635 hasConcept C134018914 @default.
• W2168996635 hasConcept C155164980 @default.
• W2168996635 hasConcept C158617107 @default.
• W2168996635 hasConcept C160145004 @default.
• W2168996635 hasConcept C167007842 @default.
• W2168996635 hasConcept C170488646 @default.
• W2168996635 hasConcept C170493617 @default.
• W2168996635 hasConcept C181080969 @default.
• W2168996635 hasConcept C185592680 @default.
• W2168996635 hasConcept C207200792 @default.
• W2168996635 hasConcept C2777146706 @default.
• W2168996635 hasConcept C2780383360 @default.
• W2168996635 hasConcept C519063684 @default.
• W2168996635 hasConcept C71924100 @default.
• W2168996635 hasConcept C86803240 @default.
• W2168996635 hasConcept C87649029 @default.
• W2168996635 hasConcept C88045685 @default.
• W2168996635 hasConcept C95444343 @default.
• W2168996635 hasConceptScore W2168996635C113217602 @default.
• W2168996635 hasConceptScore W2168996635C126322002 @default.
• W2168996635 hasConceptScore W2168996635C134018914 @default.
• W2168996635 hasConceptScore W2168996635C155164980 @default.
• W2168996635 hasConceptScore W2168996635C158617107 @default.
• W2168996635 hasConceptScore W2168996635C160145004 @default.
• W2168996635 hasConceptScore W2168996635C167007842 @default.
• W2168996635 hasConceptScore W2168996635C170488646 @default.
• W2168996635 hasConceptScore W2168996635C170493617 @default.
• W2168996635 hasConceptScore W2168996635C181080969 @default.
• W2168996635 hasConceptScore W2168996635C185592680 @default.
• W2168996635 hasConceptScore W2168996635C207200792 @default.
• W2168996635 hasConceptScore W2168996635C2777146706 @default.
• W2168996635 hasConceptScore W2168996635C2780383360 @default.
• W2168996635 hasConceptScore W2168996635C519063684 @default.
• W2168996635 hasConceptScore W2168996635C71924100 @default.
• W2168996635 hasConceptScore W2168996635C86803240 @default.
• W2168996635 hasConceptScore W2168996635C87649029 @default.
• W2168996635 hasConceptScore W2168996635C88045685 @default.
• W2168996635 hasConceptScore W2168996635C95444343 @default.

• next