FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2168996948> ?p ?o ?g. }

• W2168996948 endingPage "902" @default.
• W2168996948 startingPage "896" @default.
• W2168996948 abstract "Abstract BCR/ABL oncogene, as a result of chromosome aberration t(9;22), is the pathogenic principle of almost 95% of human chronic myeloid leukemia (CML). Imatinib (STI571) is a highly selective inhibitor of BCR/ABL oncogenic tyrosine kinase used in leukemia treatment. It has been suggested that BCR/ABL may contribute to the resistance of leukemic cells to drug and radiation through stimulation of DNA repair in these cells. To evaluate further the influence of STI571 on DNA repair we studied the efficacy of this process in BCR/ABLpositive and -negative cells using single cell electrophoresis (comet assay). In our experiments, K562 human chronic myeloid leukemia cells expressing BCR/ABL and CCRF-CEM human acute lymphoblastic leukemia cells without BCR/ABL expression were employed. The cells were exposed for 1 h at 37 ∞C to N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) at 5 μᴍ, mitomycin C (MMC) at 50 μᴍ or to γ-radiation at 15 Gy with or without a 24 h preincubation at 1 μᴍ of STI571. The MTT cells survival after 4 days of culture showed that STI571 enhanced the cytotoxity of the examined compounds in the K562 line. Further it was found, that the inhibitor decreased the efficacy of DNA repair challenged by each agent, but only in the K562 expressing BCR/ABL. Due to the variety of DNA damage induced by the employed agents in this study we can speculate, that BCR/ABL may stimulate multiple pathways of DNA repair. These results extend our previous studies performed on BCR/ABLtransformed mouse cells onto human cells. It is shown that BCR/ABL stimulated DNA repair in human leukemia cells. In conclusion we report that STI571 was found to inhibit DNA repair and abrogate BCR/ABL-positive human leukemia cells therapeutic resistance." @default.
• W2168996948 created "2016-06-24" @default.
• W2168996948 creator A5024633360 @default.
• W2168996948 creator A5027460192 @default.
• W2168996948 creator A5052186294 @default.
• W2168996948 creator A5061405772 @default.
• W2168996948 creator A5068255136 @default.
• W2168996948 creator A5075176752 @default.
• W2168996948 creator A5081449037 @default.
• W2168996948 date "2006-12-01" @default.
• W2168996948 modified "2023-10-18" @default.
• W2168996948 title "Imatinib (STI571) Inhibits DNA Repair in Human Leukemia Oncogenic Tyrosine Kinase-Expressing Cells" @default.
• W2168996948 cites W1534310027 @default.
• W2168996948 cites W1970895995 @default.
• W2168996948 cites W1979563087 @default.
• W2168996948 cites W2012569204 @default.
• W2168996948 cites W2015500565 @default.
• W2168996948 cites W2016086822 @default.
• W2168996948 cites W2023356259 @default.
• W2168996948 cites W2028959752 @default.
• W2168996948 cites W2036146312 @default.
• W2168996948 cites W2040323503 @default.
• W2168996948 cites W2040396943 @default.
• W2168996948 cites W2041440798 @default.
• W2168996948 cites W2050992307 @default.
• W2168996948 cites W2061303590 @default.
• W2168996948 cites W2078255929 @default.
• W2168996948 cites W2092629964 @default.
• W2168996948 cites W2092992436 @default.
• W2168996948 cites W2100016706 @default.
• W2168996948 cites W2102610315 @default.
• W2168996948 cites W2104800170 @default.
• W2168996948 cites W2105142153 @default.
• W2168996948 cites W2137601120 @default.
• W2168996948 cites W2148033136 @default.
• W2168996948 cites W2157069029 @default.
• W2168996948 cites W2161835431 @default.
• W2168996948 cites W2165848530 @default.
• W2168996948 doi "https://doi.org/10.1515/znc-2006-11-1219" @default.
• W2168996948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17294703" @default.
• W2168996948 hasPublicationYear "2006" @default.
• W2168996948 type Work @default.
• W2168996948 sameAs 2168996948 @default.
• W2168996948 citedByCount "7" @default.
• W2168996948 countsByYear W21689969482012 @default.
• W2168996948 countsByYear W21689969482015 @default.
• W2168996948 countsByYear W21689969482017 @default.
• W2168996948 countsByYear W21689969482018 @default.
• W2168996948 countsByYear W21689969482023 @default.
• W2168996948 crossrefType "journal-article" @default.
• W2168996948 hasAuthorship W2168996948A5024633360 @default.
• W2168996948 hasAuthorship W2168996948A5027460192 @default.
• W2168996948 hasAuthorship W2168996948A5052186294 @default.
• W2168996948 hasAuthorship W2168996948A5061405772 @default.
• W2168996948 hasAuthorship W2168996948A5068255136 @default.
• W2168996948 hasAuthorship W2168996948A5075176752 @default.
• W2168996948 hasAuthorship W2168996948A5081449037 @default.
• W2168996948 hasBestOaLocation W21689969481 @default.
• W2168996948 hasConcept C104317684 @default.
• W2168996948 hasConcept C125418893 @default.
• W2168996948 hasConcept C138626823 @default.
• W2168996948 hasConcept C143425029 @default.
• W2168996948 hasConcept C153911025 @default.
• W2168996948 hasConcept C171122931 @default.
• W2168996948 hasConcept C203014093 @default.
• W2168996948 hasConcept C2777583451 @default.
• W2168996948 hasConcept C2778461978 @default.
• W2168996948 hasConcept C2778729363 @default.
• W2168996948 hasConcept C2778904597 @default.
• W2168996948 hasConcept C3019892230 @default.
• W2168996948 hasConcept C42362537 @default.
• W2168996948 hasConcept C43907098 @default.
• W2168996948 hasConcept C502942594 @default.
• W2168996948 hasConcept C54355233 @default.
• W2168996948 hasConcept C552990157 @default.
• W2168996948 hasConcept C62478195 @default.
• W2168996948 hasConcept C86803240 @default.
• W2168996948 hasConcept C95444343 @default.
• W2168996948 hasConceptScore W2168996948C104317684 @default.
• W2168996948 hasConceptScore W2168996948C125418893 @default.
• W2168996948 hasConceptScore W2168996948C138626823 @default.
• W2168996948 hasConceptScore W2168996948C143425029 @default.
• W2168996948 hasConceptScore W2168996948C153911025 @default.
• W2168996948 hasConceptScore W2168996948C171122931 @default.
• W2168996948 hasConceptScore W2168996948C203014093 @default.
• W2168996948 hasConceptScore W2168996948C2777583451 @default.
• W2168996948 hasConceptScore W2168996948C2778461978 @default.
• W2168996948 hasConceptScore W2168996948C2778729363 @default.
• W2168996948 hasConceptScore W2168996948C2778904597 @default.
• W2168996948 hasConceptScore W2168996948C3019892230 @default.
• W2168996948 hasConceptScore W2168996948C42362537 @default.
• W2168996948 hasConceptScore W2168996948C43907098 @default.
• W2168996948 hasConceptScore W2168996948C502942594 @default.
• W2168996948 hasConceptScore W2168996948C54355233 @default.
• W2168996948 hasConceptScore W2168996948C552990157 @default.
• W2168996948 hasConceptScore W2168996948C62478195 @default.
• W2168996948 hasConceptScore W2168996948C86803240 @default.
• W2168996948 hasConceptScore W2168996948C95444343 @default.

• next