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- W2169012106 abstract "Fentanyl has been shown to be a potent analgesic with a lower propensity to produce tolerance and physical dependence in the clinical setting. The present study was designed to investigate the mechanisms of fentanyl- or morphine-induced antinociception at both supraspinal and spinal sites. In the mouse tail-flick test, the antinociceptive effects induced by both fentanyl and morphine were blocked by either the μ1-opioid receptor antagonist naloxonazine or the μ1/μ2-opioid receptor antagonist β-funaltrexamine (β-FNA) after s.c., i.c.v. or i.t. injection. In contrast, both fentanyl and morphine given i.c.v. or i.t. failed to produce antinociception in μ1-deficient CXBK mice. These findings indicate that like morphine, the antinociception induced by fentanyl may be mediated predominantly through μ1-opioid receptors at both supraspinal and spinal sites in mice. We also determined the ED50 values for s.c.-, i.c.v.- and i.t.-administered fentanyl- or morphine-induced antinociception in mice. The ED50 values for s.c.-, i.c.v.- and i.t.-administered fentanyl-induced antinociception were 73.7, 18.5 and 1.2-fold lower than that of morphine, respectively. The present data clearly suggest the usefulness of peripheral treatment with fentanyl for the control of pain." @default.
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- W2169012106 date "2002-04-01" @default.
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- W2169012106 title "Possible involvement of μ1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites" @default.
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- W2169012106 doi "https://doi.org/10.1016/s0024-3205(01)01550-8" @default.
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