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• W2169031818 abstract "Objective— Phospholipid transfer protein (PLTP) is a multifunctional, extracellular lipid transport protein that plays a major role in lipoprotein metabolism and atherosclerosis. Recent in vivo studies suggested that unlike systemic PLTP, macrophage-derived PLTP would be antiatherogenic. The present study aimed at characterizing the atheroprotective properties of macrophage-derived PLTP. Methods and Results— Peritoneal macrophages were isolated from PLTP-deficient and wild-type mice and their biochemical characteristics were compared. It is shown that macrophages isolated from PLTP-deficient mice have increased basal cholesterol content and accumulate more cholesterol in the presence of LDL compared with wild-type cells. Cholesterol parameters in macrophages of PLTP-deficient mice were normalized by dietary α-tocopherol supplementation. Conclusions— The antiatherogenic properties of macrophage-derived PLTP are related at least in part to its ability to reduce cholesterol accumulation in macrophages through changes in the α-tocopherol content and oxidative status of the cells." @default.
• W2169031818 created "2016-06-24" @default.
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• W2169031818 date "2007-11-01" @default.
• W2169031818 modified "2023-10-16" @default.
• W2169031818 title "Cholesterol Accumulation Is Increased in Macrophages of Phospholipid Transfer Protein-Deficient Mice" @default.
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• W2169031818 doi "https://doi.org/10.1161/atvbaha.107.151753" @default.
• W2169031818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17717294" @default.
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