Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169037419> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2169037419 endingPage "68" @default.
- W2169037419 startingPage "63" @default.
- W2169037419 abstract "Abstract. Acute gastric ulceration induced by haemorrhagic shock is associated with profound intramucosal acidification due to diffusion of luminal H+ into the mucosa. High-HCO3−metabolic alkalosis protects the mucosa against this ulceration, whereas low-HCO3−respiratory alkalosis does not, suggesting that lack of systemic and intramucosal HCO3−. rather than tissue acidosis per se, renders the mucosa susceptible to ulceration. In normal mucosa, disruption of the mucosal barrier by taurocholate, ethanol or acetylsalicylic acid leads to efflux of alkali (HCO3−) from the mucosa, with generation of an alkaline buffer layer at the epithelial surface to protect the mucosa from further damage. In ischaemic mucosa no such protective alkaline layer is formed, and exposure to luminal acid leads to severe acidification of and damage to the mucosa. The efflux of alkali may be driven by capillary hydrostatic pressure, since no such protective alkaline efflux occurs in vitro, but rather exposure to luminal acid and barrier-breaking agents results in intracellular acidification. The potential pathogenetic role of a disrupted intramucosal acid-base balance, as well as the protective effect of systemic and intramucosal HCO3− in acute gastric stress ulceration is further substantiated by the in vitro findings that perfusion conditions simulating in vivo ulcerogenic conditions provoke intracellular acidosis, and serosal HCO3− significantly contributes to the maintenance of normal intracellular pH in surface epithelial cells exposed to luminal acid." @default.
- W2169037419 created "2016-06-24" @default.
- W2169037419 creator A5009715215 @default.
- W2169037419 creator A5044938327 @default.
- W2169037419 creator A5079269926 @default.
- W2169037419 creator A5080445150 @default.
- W2169037419 date "1990-11-01" @default.
- W2169037419 modified "2023-09-23" @default.
- W2169037419 title "Gastric mucosal acid-base balance" @default.
- W2169037419 cites W1568332435 @default.
- W2169037419 cites W1614256109 @default.
- W2169037419 cites W1861859984 @default.
- W2169037419 cites W1992474529 @default.
- W2169037419 cites W2162820768 @default.
- W2169037419 cites W2166015696 @default.
- W2169037419 cites W297366203 @default.
- W2169037419 doi "https://doi.org/10.1111/j.1365-2796.1990.tb01474.x" @default.
- W2169037419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2200417" @default.
- W2169037419 hasPublicationYear "1990" @default.
- W2169037419 type Work @default.
- W2169037419 sameAs 2169037419 @default.
- W2169037419 citedByCount "14" @default.
- W2169037419 countsByYear W21690374192012 @default.
- W2169037419 crossrefType "journal-article" @default.
- W2169037419 hasAuthorship W2169037419A5009715215 @default.
- W2169037419 hasAuthorship W2169037419A5044938327 @default.
- W2169037419 hasAuthorship W2169037419A5079269926 @default.
- W2169037419 hasAuthorship W2169037419A5080445150 @default.
- W2169037419 hasConcept C126322002 @default.
- W2169037419 hasConcept C134018914 @default.
- W2169037419 hasConcept C134746045 @default.
- W2169037419 hasConcept C134897140 @default.
- W2169037419 hasConcept C142724271 @default.
- W2169037419 hasConcept C185592680 @default.
- W2169037419 hasConcept C2777068682 @default.
- W2169037419 hasConcept C2777504413 @default.
- W2169037419 hasConcept C2778553927 @default.
- W2169037419 hasConcept C2779422922 @default.
- W2169037419 hasConcept C2781443798 @default.
- W2169037419 hasConcept C3019368612 @default.
- W2169037419 hasConcept C49039625 @default.
- W2169037419 hasConcept C55493867 @default.
- W2169037419 hasConcept C71924100 @default.
- W2169037419 hasConcept C79879829 @default.
- W2169037419 hasConceptScore W2169037419C126322002 @default.
- W2169037419 hasConceptScore W2169037419C134018914 @default.
- W2169037419 hasConceptScore W2169037419C134746045 @default.
- W2169037419 hasConceptScore W2169037419C134897140 @default.
- W2169037419 hasConceptScore W2169037419C142724271 @default.
- W2169037419 hasConceptScore W2169037419C185592680 @default.
- W2169037419 hasConceptScore W2169037419C2777068682 @default.
- W2169037419 hasConceptScore W2169037419C2777504413 @default.
- W2169037419 hasConceptScore W2169037419C2778553927 @default.
- W2169037419 hasConceptScore W2169037419C2779422922 @default.
- W2169037419 hasConceptScore W2169037419C2781443798 @default.
- W2169037419 hasConceptScore W2169037419C3019368612 @default.
- W2169037419 hasConceptScore W2169037419C49039625 @default.
- W2169037419 hasConceptScore W2169037419C55493867 @default.
- W2169037419 hasConceptScore W2169037419C71924100 @default.
- W2169037419 hasConceptScore W2169037419C79879829 @default.
- W2169037419 hasIssue "S732" @default.
- W2169037419 hasLocation W21690374191 @default.
- W2169037419 hasLocation W21690374192 @default.
- W2169037419 hasOpenAccess W2169037419 @default.
- W2169037419 hasPrimaryLocation W21690374191 @default.
- W2169037419 hasRelatedWork W1981899953 @default.
- W2169037419 hasRelatedWork W1999918311 @default.
- W2169037419 hasRelatedWork W2026412790 @default.
- W2169037419 hasRelatedWork W2038281234 @default.
- W2169037419 hasRelatedWork W2169037419 @default.
- W2169037419 hasRelatedWork W2412483432 @default.
- W2169037419 hasRelatedWork W2413976404 @default.
- W2169037419 hasRelatedWork W2414808990 @default.
- W2169037419 hasRelatedWork W2582740796 @default.
- W2169037419 hasRelatedWork W40866122 @default.
- W2169037419 hasVolume "228" @default.
- W2169037419 isParatext "false" @default.
- W2169037419 isRetracted "false" @default.
- W2169037419 magId "2169037419" @default.
- W2169037419 workType "article" @default.