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• W2169038961 abstract "Abstract Immunity of plants triggered by pathogen-associated molecular patterns (PAMPs) is based on the execution of an evolutionarily conserved defense response that includes the accumulation of pathogenesis-related (PR) proteins as well as multiple other defenses. The most abundant PR transcript of barley (Hordeum vulgare) leaf epidermis attacked by the powdery mildew fungus Blumeria graminis f. sp hordei encodes the germin-like protein GER4, which has superoxide dismutase activity and functions in PAMP-triggered immunity. Here, we show that barley GER4 is encoded by a dense cluster of tandemly duplicated genes (GER4a-h) that underwent several cycles of duplication. The genomic organization of the GER4 locus also provides evidence for repeated gene birth and death cycles. The GER4 promoters contain multiple WRKY factor binding sites (W-boxes) preferentially located in promoter fragments that were exchanged between subfamily members by gene conversion. Mutational analysis of TATA-box proximal W-boxes used GER4c promoter-β-glucuronidase fusions to reveal their enhancing effects and functional redundancy on pathogen-induced promoter activity. The data suggest enhanced transcript dosage as an evolutionary driving force for the local expansion and functional redundancy of the GER4 locus. In addition, the GER4c promoter provides a tool to study signal transduction of PAMP-triggered immunity and to engineer strictly localized and pathogen-regulated disease resistance in transgenic cereal crops." @default.
• W2169038961 created "2016-06-24" @default.
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• W2169038961 date "2010-03-01" @default.
• W2169038961 modified "2023-10-02" @default.
• W2169038961 title "Promoters of the Barley Germin-Like<i>GER4</i>Gene Cluster Enable Strong Transgene Expression in Response to Pathogen Attack " @default.
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• W2169038961 doi "https://doi.org/10.1105/tpc.109.067934" @default.
• W2169038961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2861458" @default.
• W2169038961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20305123" @default.
• W2169038961 hasPublicationYear "2010" @default.
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