Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169044384> ?p ?o ?g. }
- W2169044384 endingPage "6425" @default.
- W2169044384 startingPage "6418" @default.
- W2169044384 abstract "Damp building-related illnesses have caused concern for years in many countries. Although the problem is extensive, the knowledge of the immunological reactions behind damp building-related illnesses is still quite limited. Trichothecene mycotoxins form one major group of toxins, which possibly contribute to the illnesses. Stachybotrys chartarum is a well-known, but also controversial damp building mold and many strains of this mold are capable of producing trichothecenes. In this report, we have examined the effect of S. chartarum and trichothecene mycotoxins on the proinflammatory cytokine response in human macrophages. As a result, satratoxin-positive S. chartarum activated inflammasome-associated caspase-1, which is needed for proteolytic processing of IL-1beta and IL-18. Furthermore, purified trichothecene mycotoxins, roridin A, verrucarin A, and T-2 toxin activated caspase-1, and these mycotoxins also strongly enhanced LPS-dependent secretion of IL-1beta and IL-18. The satratoxin-positive strain of S. chartarum and the trichothecenes also triggered the activation of caspase-3, which is an effector caspase of apoptosis. Satratoxin-negative S. chartarum was not able to activate either caspase-1 or caspase-3. In conclusion, our results indicate that human macrophages sense trichothecene mycotoxins as a danger signal, which activates caspase-1, and further enables the secretion of IL-1beta and IL-18 from the LPS-primed cells." @default.
- W2169044384 created "2016-06-24" @default.
- W2169044384 creator A5013065472 @default.
- W2169044384 creator A5013724142 @default.
- W2169044384 creator A5016170192 @default.
- W2169044384 creator A5037145306 @default.
- W2169044384 creator A5038183947 @default.
- W2169044384 creator A5041589630 @default.
- W2169044384 creator A5065247130 @default.
- W2169044384 creator A5073058257 @default.
- W2169044384 date "2009-05-15" @default.
- W2169044384 modified "2023-10-08" @default.
- W2169044384 title "Trichothecene Mycotoxins Activate Inflammatory Response in Human Macrophages" @default.
- W2169044384 cites W1510735665 @default.
- W2169044384 cites W1529674879 @default.
- W2169044384 cites W1533308200 @default.
- W2169044384 cites W1571910978 @default.
- W2169044384 cites W1621339884 @default.
- W2169044384 cites W1824528611 @default.
- W2169044384 cites W1906612937 @default.
- W2169044384 cites W1921587687 @default.
- W2169044384 cites W1968182403 @default.
- W2169044384 cites W1975648786 @default.
- W2169044384 cites W1976759029 @default.
- W2169044384 cites W1978274182 @default.
- W2169044384 cites W1979991507 @default.
- W2169044384 cites W1981106016 @default.
- W2169044384 cites W1984044351 @default.
- W2169044384 cites W1984622817 @default.
- W2169044384 cites W1985565746 @default.
- W2169044384 cites W1989038708 @default.
- W2169044384 cites W1991687281 @default.
- W2169044384 cites W1993355443 @default.
- W2169044384 cites W1995266634 @default.
- W2169044384 cites W1995744610 @default.
- W2169044384 cites W1996012789 @default.
- W2169044384 cites W2009603393 @default.
- W2169044384 cites W2009800174 @default.
- W2169044384 cites W2015734501 @default.
- W2169044384 cites W2031084334 @default.
- W2169044384 cites W2031495829 @default.
- W2169044384 cites W2032022428 @default.
- W2169044384 cites W2052842511 @default.
- W2169044384 cites W2056155809 @default.
- W2169044384 cites W2072097525 @default.
- W2169044384 cites W2072211858 @default.
- W2169044384 cites W2074213282 @default.
- W2169044384 cites W2081101945 @default.
- W2169044384 cites W2083530598 @default.
- W2169044384 cites W2086877812 @default.
- W2169044384 cites W2087797573 @default.
- W2169044384 cites W2088238268 @default.
- W2169044384 cites W2091268459 @default.
- W2169044384 cites W2092189764 @default.
- W2169044384 cites W2102550380 @default.
- W2169044384 cites W2103373332 @default.
- W2169044384 cites W2104722369 @default.
- W2169044384 cites W2114216755 @default.
- W2169044384 cites W2120352170 @default.
- W2169044384 cites W2121560754 @default.
- W2169044384 cites W2126914275 @default.
- W2169044384 cites W2127091849 @default.
- W2169044384 cites W2128749545 @default.
- W2169044384 cites W2134279006 @default.
- W2169044384 cites W2135404947 @default.
- W2169044384 cites W2140796894 @default.
- W2169044384 cites W2143525286 @default.
- W2169044384 cites W2145664163 @default.
- W2169044384 cites W2149422934 @default.
- W2169044384 cites W2152906582 @default.
- W2169044384 cites W2154205887 @default.
- W2169044384 cites W2157877066 @default.
- W2169044384 cites W2159719341 @default.
- W2169044384 cites W2166007780 @default.
- W2169044384 cites W2166780503 @default.
- W2169044384 cites W2166977760 @default.
- W2169044384 cites W2341678223 @default.
- W2169044384 cites W4211237594 @default.
- W2169044384 cites W4313306023 @default.
- W2169044384 doi "https://doi.org/10.4049/jimmunol.0803309" @default.
- W2169044384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19414795" @default.
- W2169044384 hasPublicationYear "2009" @default.
- W2169044384 type Work @default.
- W2169044384 sameAs 2169044384 @default.
- W2169044384 citedByCount "82" @default.
- W2169044384 countsByYear W21690443842012 @default.
- W2169044384 countsByYear W21690443842013 @default.
- W2169044384 countsByYear W21690443842014 @default.
- W2169044384 countsByYear W21690443842015 @default.
- W2169044384 countsByYear W21690443842016 @default.
- W2169044384 countsByYear W21690443842017 @default.
- W2169044384 countsByYear W21690443842018 @default.
- W2169044384 countsByYear W21690443842019 @default.
- W2169044384 countsByYear W21690443842020 @default.
- W2169044384 countsByYear W21690443842021 @default.
- W2169044384 countsByYear W21690443842022 @default.
- W2169044384 countsByYear W21690443842023 @default.
- W2169044384 crossrefType "journal-article" @default.