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• W2169048078 abstract "The haemolysis of sea bass Dicentrarchus labrax red blood cells (RBC) was initiated by tert ‐butyl‐hydroperoxide (t‐BHP). The onset of the haemolytic process was accelerated by increasing t‐BHP concentration. This process was preceded by a drop in the RBC glutathione content followed by the production of lipid peroxidation products. Also t‐BHP induced DNA fragmentation in RBC nuclei as measured by COMET assay. The addition of the antioxidant Trolox C® dose‐dependently delayed the onset of both lipid peroxidation and haemolysis, and protected GSH stores against t‐BHP‐induced depletion. DNA fragmentation was also pre‐vented by Trolox C®. These results indicate that t‐BHP induces haemolysis in sea bass RBC through the induction of oxidative stress. Such a simple model could prove useful for both fundamental and applied studies on marine fish antioxidant mechanisms." @default.
• W2169048078 created "2016-06-24" @default.
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• W2169048078 date "2002-07-01" @default.
• W2169048078 modified "2023-09-26" @default.
• W2169048078 title "Peroxide‐triggered erythrocytes haemolysis as a model for the study of oxidative damage in marine fishes" @default.
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• W2169048078 doi "https://doi.org/10.1111/j.1095-8649.2002.tb01737.x" @default.
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