FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169062009> ?p ?o ?g. }

• W2169062009 endingPage "3" @default.
• W2169062009 startingPage "3" @default.
• W2169062009 abstract "BACKGROUND: Respiratory symptoms, impaired lung function, and asthma have been reported in workers exposed to wood dust in a number of epidemiological studies. The underlying pathomechanisms, however, are not well understood. Here, we studied the effects of dust from pine (PD) and heat-treated pine (HPD) on the release of reactive oxygen species (ROS) and inflammatory mediators in rat alveolar macrophages. METHODS: Tumour necrosis factor-alpha (TNF-alpha) and macrophage inflammatory protein-2 (MIP-2) protein release, TNF-alpha and MIP-2 mRNA expression, and generation of ROS were studied as end points after treatment of rat alveolar macrophages with PD or HPD. In a separate series of experiments, the antioxidants glutathione and N-acetyl-L-cysteine were included in combination with wood dust. To determine the endogenous oxidative and antioxidant capacity of wood dusts, electron spin resonance (ESR) spectroscopy was used. RESULTS: After 4 h incubation, both PD and HPD elicited a significantly (p < 0.05) increased mRNA expression of TNF-alpha and MIP-2 as well as a concentration-dependent release of TNF-alpha and MIP-2 protein. Interestingly, PD induced a significantly higher TNF-alpha and MIP-2 production than HPD. Moreover, a significantly increased ROS production was observed in alveolar macrophages exposed to both PD and HPD. In the presence of the antioxidants glutathione and N-acetyl-L-cysteine, the PD- and HPD-induced release of ROS, TNF-alpha, and MIP-2 was significantly reduced. Finally, electron spin resonance analyses demonstrated a higher endogenous antioxidant capacity of HPD compared to PD. Endotoxin was not present in either dust sample. CONCLUSION: These results indicate that pine dust is able to induce expression of TNF-alpha and MIP-2 in rat alveolar macrophages by a mechanism that is, at least in part, mediated by ROS." @default.
• W2169062009 created "2016-06-24" @default.
• W2169062009 creator A5000924419 @default.
• W2169062009 creator A5046528033 @default.
• W2169062009 creator A5051278116 @default.
• W2169062009 creator A5052949222 @default.
• W2169062009 creator A5068521951 @default.
• W2169062009 creator A5083676765 @default.
• W2169062009 creator A5085566248 @default.
• W2169062009 date "2004-01-01" @default.
• W2169062009 modified "2023-09-23" @default.
• W2169062009 cites W1524166508 @default.
• W2169062009 cites W1944543056 @default.
• W2169062009 cites W1964288597 @default.
• W2169062009 cites W1983160685 @default.
• W2169062009 cites W2009194142 @default.
• W2169062009 cites W2012296679 @default.
• W2169062009 cites W2014903037 @default.
• W2169062009 cites W2027744025 @default.
• W2169062009 cites W2028793078 @default.
• W2169062009 cites W2032042910 @default.
• W2169062009 cites W2040436738 @default.
• W2169062009 cites W2044034965 @default.
• W2169062009 cites W2067934938 @default.
• W2169062009 cites W2076184158 @default.
• W2169062009 cites W2080102524 @default.
• W2169062009 cites W2081199041 @default.
• W2169062009 cites W2083845629 @default.
• W2169062009 cites W2086452129 @default.
• W2169062009 cites W2087530537 @default.
• W2169062009 cites W2089137409 @default.
• W2169062009 cites W2094484662 @default.
• W2169062009 cites W2097226799 @default.
• W2169062009 cites W2098100151 @default.
• W2169062009 cites W2100566062 @default.
• W2169062009 cites W2100750710 @default.
• W2169062009 cites W2104400074 @default.
• W2169062009 cites W2108096039 @default.
• W2169062009 cites W2109593620 @default.
• W2169062009 cites W2122905213 @default.
• W2169062009 cites W2130920625 @default.
• W2169062009 cites W2135246123 @default.
• W2169062009 cites W2136365927 @default.
• W2169062009 cites W2151805900 @default.
• W2169062009 cites W2162821429 @default.
• W2169062009 cites W157818517 @default.
• W2169062009 doi "https://doi.org/10.1186/1743-8977-1-3" @default.
• W2169062009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1074350" @default.
• W2169062009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15813983" @default.
• W2169062009 hasPublicationYear "2004" @default.
• W2169062009 type Work @default.
• W2169062009 sameAs 2169062009 @default.
• W2169062009 citedByCount "45" @default.
• W2169062009 countsByYear W21690620092012 @default.
• W2169062009 countsByYear W21690620092014 @default.
• W2169062009 countsByYear W21690620092015 @default.
• W2169062009 countsByYear W21690620092016 @default.
• W2169062009 countsByYear W21690620092017 @default.
• W2169062009 countsByYear W21690620092019 @default.
• W2169062009 countsByYear W21690620092020 @default.
• W2169062009 countsByYear W21690620092021 @default.
• W2169062009 countsByYear W21690620092022 @default.
• W2169062009 crossrefType "journal-article" @default.
• W2169062009 hasAuthorship W2169062009A5000924419 @default.
• W2169062009 hasAuthorship W2169062009A5046528033 @default.
• W2169062009 hasAuthorship W2169062009A5051278116 @default.
• W2169062009 hasAuthorship W2169062009A5052949222 @default.
• W2169062009 hasAuthorship W2169062009A5068521951 @default.
• W2169062009 hasAuthorship W2169062009A5083676765 @default.
• W2169062009 hasAuthorship W2169062009A5085566248 @default.
• W2169062009 hasBestOaLocation W21690620091 @default.
• W2169062009 hasConcept C153911025 @default.
• W2169062009 hasConcept C164027704 @default.
• W2169062009 hasConcept C16613235 @default.
• W2169062009 hasConcept C170217031 @default.
• W2169062009 hasConcept C17991360 @default.
• W2169062009 hasConcept C181199279 @default.
• W2169062009 hasConcept C185592680 @default.
• W2169062009 hasConcept C202751555 @default.
• W2169062009 hasConcept C203014093 @default.
• W2169062009 hasConcept C2776151105 @default.
• W2169062009 hasConcept C2776914184 @default.
• W2169062009 hasConcept C2778004101 @default.
• W2169062009 hasConcept C2778012055 @default.
• W2169062009 hasConcept C2778543330 @default.
• W2169062009 hasConcept C2779201268 @default.
• W2169062009 hasConcept C2779244956 @default.
• W2169062009 hasConcept C48349386 @default.
• W2169062009 hasConcept C538909803 @default.
• W2169062009 hasConcept C55493867 @default.
• W2169062009 hasConcept C86803240 @default.
• W2169062009 hasConceptScore W2169062009C153911025 @default.
• W2169062009 hasConceptScore W2169062009C164027704 @default.
• W2169062009 hasConceptScore W2169062009C16613235 @default.
• W2169062009 hasConceptScore W2169062009C170217031 @default.
• W2169062009 hasConceptScore W2169062009C17991360 @default.
• W2169062009 hasConceptScore W2169062009C181199279 @default.
• W2169062009 hasConceptScore W2169062009C185592680 @default.

• next