FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169062047> ?p ?o ?g. }

• W2169062047 endingPage "375" @default.
• W2169062047 startingPage "367" @default.
• W2169062047 abstract "Plasmid-encoded resistance to broad-spectrum cephalosporins and aztreonam is becoming a widespread phenomenon in clinical medicine. These antibiotics are inactivated by an array of different extended-spectrum β-lactamases (ESBLs) which have evolved by point mutations of parental TEM or SHV β-lactamases. In a previous study conducted during 1994-1995, SHV-2, SHV-2a and SHV-5 β-lactamases were found among Klebsiella pneumoniae isolates in Dubrava University Hospital. High prevalence of ESBLs among K. pneumoniae strains in this hospital (20%) required further investigation. In this investigation, β-lactamases from 42 K. pneumoniae strains collected in 1997 and 15 in 2004 from Dubrava University Hospital, were characterized in order to study the evolution of plasmid-encoded resistance to extended-spectrum cephalosporins and aztreonam in that hospital over a prolonged study period. Susceptibility to antibiotics was determined by diskdiffusion and broth microdilution method. β-lactamases were characterized by isoelectric focusing, determination of hydrolysis of β-lactam substrates, polymerase chain reaction and sequencing of blaSHV genes. All K. pneumoniae strains and their Escherichia coli transconjugants produced β-lactamase with an isoelectric point of 8.2. Based on sequencing of blaSHV genes enzymes of all transconjugants were identified as SHV-5 β-lactamase which conferred on the producing isolates high level of ceftazidime and aztreonam resistance. In this study, an outbreak of nosocomial infections caused by SHV-5 producing K. pneumoniae was described in 1997 which evolved to endemic spread of SHV-5 producing K. pneumoniae due to multiple plasmid transfer in the Dubrava University Hospital. The strains from 1997 and 2004 were not clonally related. Hospital hygiene measures should be applied in order to control the spread of epidemic strains through the hospital wards and the consumption of the broad-spectrum cephalosporins needs to be restricted to reduce the selection pressure which enables the proliferation of ESBL producers in hospital." @default.
• W2169062047 created "2016-06-24" @default.
• W2169062047 creator A5005615375 @default.
• W2169062047 creator A5008781637 @default.
• W2169062047 creator A5009762201 @default.
• W2169062047 creator A5022180113 @default.
• W2169062047 creator A5025612280 @default.
• W2169062047 creator A5064581165 @default.
• W2169062047 creator A5072641940 @default.
• W2169062047 creator A5081286380 @default.
• W2169062047 date "2005-08-01" @default.
• W2169062047 modified "2023-09-26" @default.
• W2169062047 title "Epidemic and Endemic Spread ofKlebsiella pneumoniaeProducing SHV-5 Beta-Lactamase in Dubrava University Hospital, Zagreb, Croatia" @default.
• W2169062047 cites W145635331 @default.
• W2169062047 cites W1658270518 @default.
• W2169062047 cites W1855450948 @default.
• W2169062047 cites W1937785817 @default.
• W2169062047 cites W1955612312 @default.
• W2169062047 cites W1966411105 @default.
• W2169062047 cites W1975618013 @default.
• W2169062047 cites W1983448974 @default.
• W2169062047 cites W1989925309 @default.
• W2169062047 cites W2002178722 @default.
• W2169062047 cites W2010182973 @default.
• W2169062047 cites W2019410656 @default.
• W2169062047 cites W2025953236 @default.
• W2169062047 cites W2029061482 @default.
• W2169062047 cites W2052840797 @default.
• W2169062047 cites W2063245322 @default.
• W2169062047 cites W2067895776 @default.
• W2169062047 cites W2078340635 @default.
• W2169062047 cites W2087310867 @default.
• W2169062047 cites W2087946388 @default.
• W2169062047 cites W2090055765 @default.
• W2169062047 cites W2095670637 @default.
• W2169062047 cites W2119630062 @default.
• W2169062047 cites W2124226097 @default.
• W2169062047 cites W2153219626 @default.
• W2169062047 cites W71214772 @default.
• W2169062047 doi "https://doi.org/10.1179/joc.2005.17.4.367" @default.
• W2169062047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16167514" @default.
• W2169062047 hasPublicationYear "2005" @default.
• W2169062047 type Work @default.
• W2169062047 sameAs 2169062047 @default.
• W2169062047 citedByCount "11" @default.
• W2169062047 countsByYear W21690620472012 @default.
• W2169062047 countsByYear W21690620472015 @default.
• W2169062047 countsByYear W21690620472017 @default.
• W2169062047 crossrefType "journal-article" @default.
• W2169062047 hasAuthorship W2169062047A5005615375 @default.
• W2169062047 hasAuthorship W2169062047A5008781637 @default.
• W2169062047 hasAuthorship W2169062047A5009762201 @default.
• W2169062047 hasAuthorship W2169062047A5022180113 @default.
• W2169062047 hasAuthorship W2169062047A5025612280 @default.
• W2169062047 hasAuthorship W2169062047A5064581165 @default.
• W2169062047 hasAuthorship W2169062047A5072641940 @default.
• W2169062047 hasAuthorship W2169062047A5081286380 @default.
• W2169062047 hasConcept C104317684 @default.
• W2169062047 hasConcept C159047783 @default.
• W2169062047 hasConcept C176947019 @default.
• W2169062047 hasConcept C2777058267 @default.
• W2169062047 hasConcept C2779631663 @default.
• W2169062047 hasConcept C2780416669 @default.
• W2169062047 hasConcept C2780950330 @default.
• W2169062047 hasConcept C3019249092 @default.
• W2169062047 hasConcept C501593827 @default.
• W2169062047 hasConcept C547475151 @default.
• W2169062047 hasConcept C55493867 @default.
• W2169062047 hasConcept C64778159 @default.
• W2169062047 hasConcept C71924100 @default.
• W2169062047 hasConcept C86803240 @default.
• W2169062047 hasConcept C89423630 @default.
• W2169062047 hasConcept C94665300 @default.
• W2169062047 hasConceptScore W2169062047C104317684 @default.
• W2169062047 hasConceptScore W2169062047C159047783 @default.
• W2169062047 hasConceptScore W2169062047C176947019 @default.
• W2169062047 hasConceptScore W2169062047C2777058267 @default.
• W2169062047 hasConceptScore W2169062047C2779631663 @default.
• W2169062047 hasConceptScore W2169062047C2780416669 @default.
• W2169062047 hasConceptScore W2169062047C2780950330 @default.
• W2169062047 hasConceptScore W2169062047C3019249092 @default.
• W2169062047 hasConceptScore W2169062047C501593827 @default.
• W2169062047 hasConceptScore W2169062047C547475151 @default.
• W2169062047 hasConceptScore W2169062047C55493867 @default.
• W2169062047 hasConceptScore W2169062047C64778159 @default.
• W2169062047 hasConceptScore W2169062047C71924100 @default.
• W2169062047 hasConceptScore W2169062047C86803240 @default.
• W2169062047 hasConceptScore W2169062047C89423630 @default.
• W2169062047 hasConceptScore W2169062047C94665300 @default.
• W2169062047 hasIssue "4" @default.
• W2169062047 hasLocation W21690620471 @default.
• W2169062047 hasLocation W21690620472 @default.
• W2169062047 hasOpenAccess W2169062047 @default.
• W2169062047 hasPrimaryLocation W21690620471 @default.
• W2169062047 hasRelatedWork W1889432453 @default.
• W2169062047 hasRelatedWork W2009267332 @default.
• W2169062047 hasRelatedWork W2010182973 @default.
• W2169062047 hasRelatedWork W2024015098 @default.

• next