FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169063756> ?p ?o ?g. }

• W2169063756 endingPage "A22" @default.
• W2169063756 startingPage "A22" @default.
• W2169063756 abstract "A 52-year-old woman was admitted for increasing severe pain in her feet during the previous month. Her symptoms began 2 years earlier when she noticed skin discoloration and occasional blisters in her feet that became worse before admission. Her medical history included dyslipidemia and hepatitis C virus (HCV) infection incompletely treated 4 years earlier. On physical examination, she had livedo reticularis (Figure A) with purple skin discoloration and blisters on the dorsum of the feet. In addition, severe distal necrosis of the toes with diminished pedal pulses was seen (Figure B). Significant laboratory results included positive serum mixed cryoglobulin type II titer, elevated rheumatoid factor (127 IU/mL), low C3 and C4 levels, and an HCV RNA viral load of 153,000 IU/mL. Skin biopsy of lower extremities confirmed leukocytoclastic vasculitis (Figure C). An arterial ultrasound of lower extremities showed mild-to-moderate plaques bilaterally with no significant stenosis. Angiographic studies showed aneurysms in the abdominal aorta and right common femoral artery. Clinical and laboratory findings were attributed to mixed cryoglobulinemia. The patient underwent bilateral amputation of lower extremities and treatment with pulse steroids. Cryoglobulinemia can be detected in 36%–55% of patients infected with HCV, but only 3% develop vasculitic manifestations.1Agnello V. Chung R.T. Kaplan L.M. A role for hepatitis C virus infection in type II cryoglobulinemia.N Engl J Med. 1992; 327: 1490-1495Crossref PubMed Scopus (1331) Google Scholar, 2Agnello V. De Rosa F.G. Extrahepatic disease manifestations of HCV infection: some current issues.J Hepatol. 2004; 40: 341-352Abstract Full Text Full Text PDF PubMed Scopus (140) Google Scholar The most common clinical manifestations are cutaneous vasculitis, arthritis, peripheral neuropathy, and glomerulonephritis.2Agnello V. De Rosa F.G. Extrahepatic disease manifestations of HCV infection: some current issues.J Hepatol. 2004; 40: 341-352Abstract Full Text Full Text PDF PubMed Scopus (140) Google Scholar Cutaneous vasculitis in mixed type II cryoglobulinemia is characterized by an orthostatic purpura in lower extremities caused by venous stasis and a nonspecific leukocytoclastic vasculitis with infiltration of skin, vessel walls, and microvascular thrombosis3Iannuzzella F. Vaglio A. Garini G. Management of hepatitis C virus-related mixed cryoglobulinemia.Am J Med. 2010; 123: 400-408Abstract Full Text Full Text PDF PubMed Scopus (49) Google Scholar; typically the presentation is not livedo or skin necrosis.4Brouet J.C. Clauvel J.P. Danon F. et al.Biologic and clinical significance of cryoglobulins: a report of 86 cases.Am J Med. 1974; 57: 775Abstract Full Text PDF PubMed Scopus (1443) Google Scholar The bilateral nature of the necrosis with insignificant arterial stenosis in this patient suggests diffuse systemic medium and small vessel disease. Endothelial dysfunction, atherosclerotic plaques, and vascular infiltration by immunocomplexes could cause this rapid presentation of bilateral foot necrosis. The virologic response to antiviral therapy in HCV patients is not affected by the concurrent presentation of mixed cryoglobulinemia, and small studies show an improvement of cutaneous symptoms.3Iannuzzella F. Vaglio A. Garini G. Management of hepatitis C virus-related mixed cryoglobulinemia.Am J Med. 2010; 123: 400-408Abstract Full Text Full Text PDF PubMed Scopus (49) Google Scholar, 5Polzien F. Schott P. Mihm S. et al.Interferon-alpha treatment of hepatitis C virus-associated mixed cryoglobulinemia.J Hepatol. 1997; 27: 63-71Abstract Full Text PDF PubMed Scopus (47) Google Scholar, 6Misiani R. Bellavita P. Fenili D. Interferon alfa-2a therapy in cryoglobulinemia with hepatitis C virus.N Engl J Med. 1994; 330: 75Crossref PubMed Scopus (639) Google Scholar Symptomatic response can be as high as 80% in patients receiving antiviral therapy, even when not associated with serologic response.7Joshi S. Kuczynski M. Heathcote E.J. Symptomatic and virological response to antiviral therapy in hepatitis C associated with extrahepatic complications of cryoglobulimia.Dig Dis Sci. 2007; 52: 2410-2417Crossref PubMed Scopus (24) Google Scholar However, the clinical remission is mostly limited to mild-to-moderate disease activity, and it is doubtful if it will improve symptoms in cases like ours with severe manifestations." @default.
• W2169063756 created "2016-06-24" @default.
• W2169063756 creator A5012943349 @default.
• W2169063756 creator A5022411275 @default.
• W2169063756 creator A5044808426 @default.
• W2169063756 date "2011-09-01" @default.
• W2169063756 modified "2023-09-26" @default.
• W2169063756 title "Bilateral Foot Necrosis Caused by Hepatitis C Virus–Induced Mixed Type II Cryoglobulinemia" @default.
• W2169063756 cites W1985104325 @default.
• W2169063756 cites W2018427484 @default.
• W2169063756 cites W2022648937 @default.
• W2169063756 cites W2040551777 @default.
• W2169063756 cites W2158977173 @default.
• W2169063756 cites W2312265932 @default.
• W2169063756 cites W2324507396 @default.
• W2169063756 doi "https://doi.org/10.1016/j.cgh.2011.05.004" @default.
• W2169063756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21699801" @default.
• W2169063756 hasPublicationYear "2011" @default.
• W2169063756 type Work @default.
• W2169063756 sameAs 2169063756 @default.
• W2169063756 citedByCount "0" @default.
• W2169063756 crossrefType "journal-article" @default.
• W2169063756 hasAuthorship W2169063756A5012943349 @default.
• W2169063756 hasAuthorship W2169063756A5022411275 @default.
• W2169063756 hasAuthorship W2169063756A5044808426 @default.
• W2169063756 hasBestOaLocation W21690637561 @default.
• W2169063756 hasConcept C126322002 @default.
• W2169063756 hasConcept C141071460 @default.
• W2169063756 hasConcept C16005928 @default.
• W2169063756 hasConcept C203014093 @default.
• W2169063756 hasConcept C2522874641 @default.
• W2169063756 hasConcept C2775934546 @default.
• W2169063756 hasConcept C2776015282 @default.
• W2169063756 hasConcept C2776408679 @default.
• W2169063756 hasConcept C2776455275 @default.
• W2169063756 hasConcept C2776626339 @default.
• W2169063756 hasConcept C2778922544 @default.
• W2169063756 hasConcept C2779134260 @default.
• W2169063756 hasConcept C2779974317 @default.
• W2169063756 hasConcept C2780439664 @default.
• W2169063756 hasConcept C71924100 @default.
• W2169063756 hasConcept C90924648 @default.
• W2169063756 hasConceptScore W2169063756C126322002 @default.
• W2169063756 hasConceptScore W2169063756C141071460 @default.
• W2169063756 hasConceptScore W2169063756C16005928 @default.
• W2169063756 hasConceptScore W2169063756C203014093 @default.
• W2169063756 hasConceptScore W2169063756C2522874641 @default.
• W2169063756 hasConceptScore W2169063756C2775934546 @default.
• W2169063756 hasConceptScore W2169063756C2776015282 @default.
• W2169063756 hasConceptScore W2169063756C2776408679 @default.
• W2169063756 hasConceptScore W2169063756C2776455275 @default.
• W2169063756 hasConceptScore W2169063756C2776626339 @default.
• W2169063756 hasConceptScore W2169063756C2778922544 @default.
• W2169063756 hasConceptScore W2169063756C2779134260 @default.
• W2169063756 hasConceptScore W2169063756C2779974317 @default.
• W2169063756 hasConceptScore W2169063756C2780439664 @default.
• W2169063756 hasConceptScore W2169063756C71924100 @default.
• W2169063756 hasConceptScore W2169063756C90924648 @default.
• W2169063756 hasIssue "9" @default.
• W2169063756 hasLocation W21690637561 @default.
• W2169063756 hasLocation W21690637562 @default.
• W2169063756 hasOpenAccess W2169063756 @default.
• W2169063756 hasPrimaryLocation W21690637561 @default.
• W2169063756 hasRelatedWork W115156286 @default.
• W2169063756 hasRelatedWork W1515913494 @default.
• W2169063756 hasRelatedWork W2061912547 @default.
• W2169063756 hasRelatedWork W2086973706 @default.
• W2169063756 hasRelatedWork W2297218150 @default.
• W2169063756 hasRelatedWork W2473610180 @default.
• W2169063756 hasRelatedWork W2537134414 @default.
• W2169063756 hasRelatedWork W2978404290 @default.
• W2169063756 hasRelatedWork W3207834286 @default.
• W2169063756 hasRelatedWork W4367281953 @default.
• W2169063756 hasVolume "9" @default.
• W2169063756 isParatext "false" @default.
• W2169063756 isRetracted "false" @default.
• W2169063756 magId "2169063756" @default.
• W2169063756 workType "article" @default.