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- W2169071211 abstract "Hexane and dichloromethane extracts of Platostoma africanum P. Beauv., a plant popularly employed in Nigeria in the treatment of rheumatic symptoms, were evaluated for anti-inflammatory and antioxidant activities. Acute inflammatory effects were studied in the egg-albumin-induced rat paw edema. Both extracts produced significant (p < 0.05) and dose-dependent inhibition of the egg-albumin-induced pedal edema with the 400 mg kg(-1) dose being markedly better than piroxicam. The hexane and dichloromethane extracts also showed significant antioxidant activity with the dichloromethane extract exhibiting an IC(50) comparable to that of BHT, a synthetic antioxidant. Phytochemical investigation of the extracts afforded eight acidic pentacyclic triterpenes, namely, ursolic acid, oleanolic acid, epimaslinic acid, maslinic acid, corosolic acid, hyptadienic, euscaphic acid and tomentic acid, and a mixture of beta-sitosterol and stigmasterol. These constituents are reported for the first time in the genus." @default.
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- W2169071211 date "2008-08-15" @default.
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- W2169071211 title "Anti-inflammatory and antioxidant activities and constituents of<i>Platostoma africanum</i>P. Beauv." @default.
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- W2169071211 doi "https://doi.org/10.1080/14786410802264004" @default.
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