FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169071674> ?p ?o ?g. }

• W2169071674 endingPage "617" @default.
• W2169071674 startingPage "607" @default.
• W2169071674 abstract "Recent findings suggest that bone marrow (BM) cells have the capacity to differentiate into a variety of cell types including endocrine cells of the pancreas. We report that BM derived cells, when cultured under defined conditions, were induced to trans-differentiate into insulin-producing cells. Furthermore, these insulin-producing cells formed aggregates that, upon transplantation into mice, acquired architecture similar to islets of Langerhans. These aggregates showed endocrine gene expression for insulin (I and II), glucagon, somatostatin and pancreatic polypeptide. Immunohistochemistry also confirmed that these aggregates were positive for insulin, somatostatin, pancreatic polypeptide and C-peptide. Also, Western and ELISA analysis demonstrated expression of proinsulin and/or secretion of active insulin upon glucose challenge. Subcapsular renal transplantation of these aggregates into hyperglycemic mice lowered circulating blood glucose levels and maintained comparatively normal glucose levels for up to 90 days post-transplantation. Graft removal resulted in rapid relapse and death in experimental animals. In addition, electron microscopy revealed these aggregates had acquired ultrastructure typically associated with mature beta (beta) cells. These results demonstrate that adult BM cells are capable of trans-differentiating into a pancreatic lineage in vitro and may represent a pool of cells for the treatment of diabetes mellitus." @default.
• W2169071674 created "2016-06-24" @default.
• W2169071674 creator A5013075148 @default.
• W2169071674 creator A5029251378 @default.
• W2169071674 creator A5031272746 @default.
• W2169071674 creator A5040832219 @default.
• W2169071674 creator A5083745204 @default.
• W2169071674 creator A5085703981 @default.
• W2169071674 date "2004-03-22" @default.
• W2169071674 modified "2023-10-16" @default.
• W2169071674 title "Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes" @default.
• W2169071674 cites W1518831632 @default.
• W2169071674 cites W1559343962 @default.
• W2169071674 cites W1565526431 @default.
• W2169071674 cites W1964720896 @default.
• W2169071674 cites W1973278012 @default.
• W2169071674 cites W1982022033 @default.
• W2169071674 cites W1985397695 @default.
• W2169071674 cites W1990854759 @default.
• W2169071674 cites W1991248271 @default.
• W2169071674 cites W1991374176 @default.
• W2169071674 cites W1996884864 @default.
• W2169071674 cites W2008477650 @default.
• W2169071674 cites W201311939 @default.
• W2169071674 cites W2025784989 @default.
• W2169071674 cites W2030771547 @default.
• W2169071674 cites W2034639280 @default.
• W2169071674 cites W2050551968 @default.
• W2169071674 cites W2056150103 @default.
• W2169071674 cites W2059066863 @default.
• W2169071674 cites W2074045232 @default.
• W2169071674 cites W2076770967 @default.
• W2169071674 cites W2079733011 @default.
• W2169071674 cites W2089154676 @default.
• W2169071674 cites W2098338322 @default.
• W2169071674 cites W2107660103 @default.
• W2169071674 cites W2109794889 @default.
• W2169071674 cites W2120695887 @default.
• W2169071674 cites W2121172969 @default.
• W2169071674 cites W2123480703 @default.
• W2169071674 cites W2131388270 @default.
• W2169071674 cites W2146383332 @default.
• W2169071674 cites W2158048826 @default.
• W2169071674 cites W2328786770 @default.
• W2169071674 cites W4232574208 @default.
• W2169071674 cites W4243820570 @default.
• W2169071674 doi "https://doi.org/10.1038/labinvest.3700074" @default.
• W2169071674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15034596" @default.
• W2169071674 hasPublicationYear "2004" @default.
• W2169071674 type Work @default.
• W2169071674 sameAs 2169071674 @default.
• W2169071674 citedByCount "269" @default.
• W2169071674 countsByYear W21690716742012 @default.
• W2169071674 countsByYear W21690716742013 @default.
• W2169071674 countsByYear W21690716742014 @default.
• W2169071674 countsByYear W21690716742015 @default.
• W2169071674 countsByYear W21690716742016 @default.
• W2169071674 countsByYear W21690716742017 @default.
• W2169071674 countsByYear W21690716742018 @default.
• W2169071674 countsByYear W21690716742019 @default.
• W2169071674 countsByYear W21690716742020 @default.
• W2169071674 countsByYear W21690716742021 @default.
• W2169071674 countsByYear W21690716742022 @default.
• W2169071674 countsByYear W21690716742023 @default.
• W2169071674 crossrefType "journal-article" @default.
• W2169071674 hasAuthorship W2169071674A5013075148 @default.
• W2169071674 hasAuthorship W2169071674A5029251378 @default.
• W2169071674 hasAuthorship W2169071674A5031272746 @default.
• W2169071674 hasAuthorship W2169071674A5040832219 @default.
• W2169071674 hasAuthorship W2169071674A5083745204 @default.
• W2169071674 hasAuthorship W2169071674A5085703981 @default.
• W2169071674 hasBestOaLocation W21690716741 @default.
• W2169071674 hasConcept C103395026 @default.
• W2169071674 hasConcept C126322002 @default.
• W2169071674 hasConcept C134018914 @default.
• W2169071674 hasConcept C152091265 @default.
• W2169071674 hasConcept C165220095 @default.
• W2169071674 hasConcept C2776297358 @default.
• W2169071674 hasConcept C2778108375 @default.
• W2169071674 hasConcept C2778563252 @default.
• W2169071674 hasConcept C2778764654 @default.
• W2169071674 hasConcept C2779306644 @default.
• W2169071674 hasConcept C2779855799 @default.
• W2169071674 hasConcept C2780007613 @default.
• W2169071674 hasConcept C2911091166 @default.
• W2169071674 hasConcept C46699223 @default.
• W2169071674 hasConcept C555293320 @default.
• W2169071674 hasConcept C71315377 @default.
• W2169071674 hasConcept C71924100 @default.
• W2169071674 hasConcept C86803240 @default.
• W2169071674 hasConcept C90061646 @default.
• W2169071674 hasConceptScore W2169071674C103395026 @default.
• W2169071674 hasConceptScore W2169071674C126322002 @default.
• W2169071674 hasConceptScore W2169071674C134018914 @default.
• W2169071674 hasConceptScore W2169071674C152091265 @default.
• W2169071674 hasConceptScore W2169071674C165220095 @default.
• W2169071674 hasConceptScore W2169071674C2776297358 @default.
• W2169071674 hasConceptScore W2169071674C2778108375 @default.

• next