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- W2169073569 abstract "Formation of macrophage-derived foam cells is a hallmark in earlier stages of atherosclerosis (AS). Increased cholesterol efflux from macrophage foam cells promote atherosclerotic regression. In the present study, lysophosphatidylcholine (LPC) promoting cholesterol efflux from macrophage foam cells was observed, and the mechanism underlying the action was investigated. Macrophage foam cells from mice were incubated with different concentrations of LPC (10, 20, 40, 80 µM), and the free cholesterol in medium increased but total intracellular cholesterol decreased. At the same time, the expression of PPARγ, LXRα, ABCA1 was enhanced in a dose-dependent manner. The treatment of macrophage foam cells with 40 µM LPC for 12, 24 and 48 h promoted cellular cholesterol efflux in a time-dependent manner, meanwhile expression of PPARγ, LXRα, ABCA1 was also raised respectively. Addition of different specific inhibitors of PPARγ (GW9662), LXRα (GGPP), ABCA1 (DIDS) to the foam cells significantly suppressed LPC-induced cholesterol efflux. Also treatment with specific inhibitors of PPARγ or LXRα decreased ABCA1 mRNA and protein expressions. LPC (40 µM)-induced cholesterol efflux was significantly lower in macrophage foam cells from apoE deficient mice than from normal C57BL/6J mice. In contrast, 10 µg apoAI-induced cholesterol efflux from foam cells remained in apoE deficient mice. The present results indicate that LPC promotes cholesterol efflux from macrophage foam cells via a PPARγ-LXRα-ABCA1-dependent pathway. Furthermore, apoE may be involved in this process. Copyright © 2006 John Wiley & Sons, Ltd." @default.
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- W2169073569 date "2006-01-01" @default.
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- W2169073569 title "Lysophosphatidylcholine promotes cholesterol efflux from mouse macrophage foam cells via PPARγ-LXRα-ABCA1-dependent pathway associated with apoE" @default.
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- W2169073569 doi "https://doi.org/10.1002/cbf.1374" @default.
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