Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169085089> ?p ?o ?g. }
- W2169085089 endingPage "490" @default.
- W2169085089 startingPage "477" @default.
- W2169085089 abstract "Polζ is an error-prone DNA polymerase that is critical for embryonic development and maintenance of genome stability. To analyze its suggested role in somatic hypermutation (SHM) and possible contribution to DNA double-strand break (DSB) repair in class switch recombination (CSR), we ablated Rev3, the catalytic subunit of Polζ, selectively in mature B cells in vivo. The frequency of somatic mutation was reduced in the mutant cells but the pattern of SHM was unaffected. Rev3-deficient B cells also exhibited pronounced chromosomal instability and impaired proliferation capacity. Although the data thus argue against a direct role of Polζ in SHM, Polζ deficiency directly interfered with CSR in that activated Rev3-deficient B cells exhibited a reduced efficiency of CSR and an increased frequency of DNA breaks in the immunoglobulin H locus. Based on our results, we suggest a nonredundant role of Polζ in DNA DSB repair through nonhomologous end joining." @default.
- W2169085089 created "2016-06-24" @default.
- W2169085089 creator A5012958604 @default.
- W2169085089 creator A5033821931 @default.
- W2169085089 creator A5033994830 @default.
- W2169085089 creator A5034117446 @default.
- W2169085089 creator A5057518210 @default.
- W2169085089 creator A5066680729 @default.
- W2169085089 creator A5067384764 @default.
- W2169085089 creator A5087283200 @default.
- W2169085089 date "2009-02-09" @default.
- W2169085089 modified "2023-09-26" @default.
- W2169085089 title "Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability" @default.
- W2169085089 cites W1504583071 @default.
- W2169085089 cites W1521082945 @default.
- W2169085089 cites W1585006893 @default.
- W2169085089 cites W1966075431 @default.
- W2169085089 cites W1966200086 @default.
- W2169085089 cites W1968963646 @default.
- W2169085089 cites W1973769556 @default.
- W2169085089 cites W1975431323 @default.
- W2169085089 cites W1975506497 @default.
- W2169085089 cites W1982406824 @default.
- W2169085089 cites W1982905137 @default.
- W2169085089 cites W1983365601 @default.
- W2169085089 cites W1992783373 @default.
- W2169085089 cites W2002043709 @default.
- W2169085089 cites W2008489452 @default.
- W2169085089 cites W2015414930 @default.
- W2169085089 cites W2018861546 @default.
- W2169085089 cites W2027083790 @default.
- W2169085089 cites W2028649337 @default.
- W2169085089 cites W2031263707 @default.
- W2169085089 cites W2036339686 @default.
- W2169085089 cites W2038560210 @default.
- W2169085089 cites W2058806464 @default.
- W2169085089 cites W2059574913 @default.
- W2169085089 cites W2063662558 @default.
- W2169085089 cites W2064194162 @default.
- W2169085089 cites W2065767588 @default.
- W2169085089 cites W2072289417 @default.
- W2169085089 cites W2080292702 @default.
- W2169085089 cites W2081243159 @default.
- W2169085089 cites W2081804926 @default.
- W2169085089 cites W2094094914 @default.
- W2169085089 cites W2100518470 @default.
- W2169085089 cites W2102129515 @default.
- W2169085089 cites W2103489555 @default.
- W2169085089 cites W2103900688 @default.
- W2169085089 cites W2103922165 @default.
- W2169085089 cites W2104809534 @default.
- W2169085089 cites W2106053750 @default.
- W2169085089 cites W2110394056 @default.
- W2169085089 cites W2111608707 @default.
- W2169085089 cites W2112640636 @default.
- W2169085089 cites W2114863275 @default.
- W2169085089 cites W2114983967 @default.
- W2169085089 cites W2120041375 @default.
- W2169085089 cites W2120490035 @default.
- W2169085089 cites W2136978195 @default.
- W2169085089 cites W2140823313 @default.
- W2169085089 cites W2144548083 @default.
- W2169085089 cites W2145836514 @default.
- W2169085089 cites W2146355613 @default.
- W2169085089 cites W2149515182 @default.
- W2169085089 cites W2150010396 @default.
- W2169085089 cites W2151893163 @default.
- W2169085089 cites W2155947081 @default.
- W2169085089 cites W2162206449 @default.
- W2169085089 cites W2165608602 @default.
- W2169085089 cites W2168558225 @default.
- W2169085089 cites W2169156878 @default.
- W2169085089 cites W2169474275 @default.
- W2169085089 cites W2171933020 @default.
- W2169085089 cites W2470508052 @default.
- W2169085089 doi "https://doi.org/10.1084/jem.20080669" @default.
- W2169085089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2646585" @default.
- W2169085089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19204108" @default.
- W2169085089 hasPublicationYear "2009" @default.
- W2169085089 type Work @default.
- W2169085089 sameAs 2169085089 @default.
- W2169085089 citedByCount "66" @default.
- W2169085089 countsByYear W21690850892012 @default.
- W2169085089 countsByYear W21690850892013 @default.
- W2169085089 countsByYear W21690850892014 @default.
- W2169085089 countsByYear W21690850892015 @default.
- W2169085089 countsByYear W21690850892016 @default.
- W2169085089 countsByYear W21690850892017 @default.
- W2169085089 countsByYear W21690850892018 @default.
- W2169085089 countsByYear W21690850892019 @default.
- W2169085089 countsByYear W21690850892020 @default.
- W2169085089 countsByYear W21690850892021 @default.
- W2169085089 countsByYear W21690850892022 @default.
- W2169085089 countsByYear W21690850892023 @default.
- W2169085089 crossrefType "journal-article" @default.
- W2169085089 hasAuthorship W2169085089A5012958604 @default.
- W2169085089 hasAuthorship W2169085089A5033821931 @default.
- W2169085089 hasAuthorship W2169085089A5033994830 @default.