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• W2169087118 abstract "This work is motivated by experimental observations that cells on stretched substrate exhibit different responses to static and dynamic loads. A model of focal adhesion that can consider the mechanics of stress fiber, adhesion bonds, and substrate was developed at the molecular level by treating the focal adhesion as an adhesion cluster. The stability of the cluster under dynamic load was studied by applying cyclic external strain on the substrate. We show that a threshold value of external strain amplitude exists beyond which the adhesion cluster disrupts quickly. In addition, our results show that the adhesion cluster is prone to losing stability under high-frequency loading, because the receptors and ligands cannot get enough contact time to form bonds due to the high-speed deformation of the substrate. At the same time, the viscoelastic stress fiber becomes rigid at high frequency, which leads to significant deformation of the bonds. Furthermore, we find that the stiffness and relaxation time of stress fibers play important roles in the stability of the adhesion cluster. The essence of this work is to connect the dynamics of the adhesion bonds (molecular level) with the cell's behavior during reorientation (cell level) through the mechanics of stress fiber. The predictions of the cluster model are consistent with experimental observations." @default.
• W2169087118 created "2016-06-24" @default.
• W2169087118 creator A5021492848 @default.
• W2169087118 creator A5059971355 @default.
• W2169087118 creator A5075932294 @default.
• W2169087118 date "2008-10-01" @default.
• W2169087118 modified "2023-10-11" @default.
• W2169087118 title "Stability of Adhesion Clusters and Cell Reorientation under Lateral Cyclic Tension" @default.
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• W2169087118 doi "https://doi.org/10.1529/biophysj.108.131342" @default.
• W2169087118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2553124" @default.
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• W2169087118 hasPublicationYear "2008" @default.
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