FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2169090256> ?p ?o ?g. }

• W2169090256 endingPage "4520" @default.
• W2169090256 startingPage "4511" @default.
• W2169090256 abstract "Vision in all vertebrates is dependent on an exchange of retinoids between the retinal pigment epithelium and the visual photoreceptors. It has been proposed that the interphotoreceptor retinoid-binding protein (IRBP) is essential for this intercellular exchange, and that it serves to prevent the potentially cytotoxic effects of retinoids. Although its precise function <i>in vivo</i> has yet to be defined, the early expression of IRBP suggests that it may also be required for normal photoreceptor development. To further assess the biological role of IRBP, we generated transgenic mice with targeted disruption of the IRBP gene (<i>IRBP</i>−/− mice). Specifically, homologous recombination was used to replace the first exon and promoter region of the IRBP gene with a phosphoglycerate kinase-promoted neomycin-resistant gene. Immunocytochemical and Western blot analyses demonstrated the absence of IRBP expression in the<i>IRBP</i>−/− mice. As early as postnatal day 11, histological examination of the retinas of <i>IRBP</i>−/− mice revealed a loss of photoreceptor nuclei and changes in the structural integrity of the receptor outer segments. At 30 d of age, the photoreceptor abnormalities in <i>IRBP</i>−/− mice were more severe, and electroretinographic recordings revealed a marked loss in photic sensitivity. In contrast, no morphological or electrophysiological changes were detected in age-matched heterozygotes. These observations indicate that normal photoreceptor development and function are highly dependent on the early expression of IRBP, and that in the absence of IRBP there is a slowly progressive degeneration of retinal photoreceptors." @default.
• W2169090256 created "2016-06-24" @default.
• W2169090256 creator A5002543910 @default.
• W2169090256 creator A5006034655 @default.
• W2169090256 creator A5009861309 @default.
• W2169090256 creator A5011761314 @default.
• W2169090256 creator A5024900490 @default.
• W2169090256 creator A5030710435 @default.
• W2169090256 creator A5030867430 @default.
• W2169090256 creator A5069241630 @default.
• W2169090256 creator A5072735381 @default.
• W2169090256 creator A5087775515 @default.
• W2169090256 date "1998-06-15" @default.
• W2169090256 modified "2023-09-24" @default.
• W2169090256 title "Early Onset Photoreceptor Abnormalities Induced by Targeted Disruption of the Interphotoreceptor Retinoid-Binding Protein Gene" @default.
• W2169090256 cites W1503520330 @default.
• W2169090256 cites W1546961042 @default.
• W2169090256 cites W1589587808 @default.
• W2169090256 cites W1602141111 @default.
• W2169090256 cites W1930334626 @default.
• W2169090256 cites W1972571085 @default.
• W2169090256 cites W1973007853 @default.
• W2169090256 cites W1973304749 @default.
• W2169090256 cites W1973886794 @default.
• W2169090256 cites W1975075223 @default.
• W2169090256 cites W1975358267 @default.
• W2169090256 cites W1976071843 @default.
• W2169090256 cites W1976805188 @default.
• W2169090256 cites W1983237714 @default.
• W2169090256 cites W1986127769 @default.
• W2169090256 cites W1993834457 @default.
• W2169090256 cites W2000890912 @default.
• W2169090256 cites W2007208973 @default.
• W2169090256 cites W2007545854 @default.
• W2169090256 cites W2009413307 @default.
• W2169090256 cites W2011947099 @default.
• W2169090256 cites W2013046627 @default.
• W2169090256 cites W2015194672 @default.
• W2169090256 cites W2017344454 @default.
• W2169090256 cites W2019461623 @default.
• W2169090256 cites W2022592544 @default.
• W2169090256 cites W2024664315 @default.
• W2169090256 cites W2037005388 @default.
• W2169090256 cites W2044721940 @default.
• W2169090256 cites W2045348184 @default.
• W2169090256 cites W204633197 @default.
• W2169090256 cites W2048188877 @default.
• W2169090256 cites W2051663781 @default.
• W2169090256 cites W2054326088 @default.
• W2169090256 cites W205550050 @default.
• W2169090256 cites W2056618475 @default.
• W2169090256 cites W2063260429 @default.
• W2169090256 cites W2063991093 @default.
• W2169090256 cites W2068593589 @default.
• W2169090256 cites W2069720648 @default.
• W2169090256 cites W2074007236 @default.
• W2169090256 cites W2074402178 @default.
• W2169090256 cites W2075921652 @default.
• W2169090256 cites W2084466106 @default.
• W2169090256 cites W2092493506 @default.
• W2169090256 cites W2095707637 @default.
• W2169090256 cites W2113045051 @default.
• W2169090256 cites W2139477501 @default.
• W2169090256 cites W2156704078 @default.
• W2169090256 cites W2187765224 @default.
• W2169090256 cites W4253196264 @default.
• W2169090256 cites W2406632037 @default.
• W2169090256 doi "https://doi.org/10.1523/jneurosci.18-12-04511.1998" @default.
• W2169090256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6792688" @default.
• W2169090256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9614228" @default.
• W2169090256 hasPublicationYear "1998" @default.
• W2169090256 type Work @default.
• W2169090256 sameAs 2169090256 @default.
• W2169090256 citedByCount "108" @default.
• W2169090256 countsByYear W21690902562012 @default.
• W2169090256 countsByYear W21690902562013 @default.
• W2169090256 countsByYear W21690902562014 @default.
• W2169090256 countsByYear W21690902562015 @default.
• W2169090256 countsByYear W21690902562016 @default.
• W2169090256 countsByYear W21690902562017 @default.
• W2169090256 countsByYear W21690902562018 @default.
• W2169090256 countsByYear W21690902562019 @default.
• W2169090256 countsByYear W21690902562020 @default.
• W2169090256 countsByYear W21690902562021 @default.
• W2169090256 countsByYear W21690902562022 @default.
• W2169090256 countsByYear W21690902562023 @default.
• W2169090256 crossrefType "journal-article" @default.
• W2169090256 hasAuthorship W2169090256A5002543910 @default.
• W2169090256 hasAuthorship W2169090256A5006034655 @default.
• W2169090256 hasAuthorship W2169090256A5009861309 @default.
• W2169090256 hasAuthorship W2169090256A5011761314 @default.
• W2169090256 hasAuthorship W2169090256A5024900490 @default.
• W2169090256 hasAuthorship W2169090256A5030710435 @default.
• W2169090256 hasAuthorship W2169090256A5030867430 @default.
• W2169090256 hasAuthorship W2169090256A5069241630 @default.
• W2169090256 hasAuthorship W2169090256A5072735381 @default.
• W2169090256 hasAuthorship W2169090256A5087775515 @default.
• W2169090256 hasBestOaLocation W21690902561 @default.

• next