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• W2169090274 abstract "Growth and differentiation of multicellular systems is orchestrated by spatially restricted gene expression programs in specialized subpopulations. The targeted manipulation of such processes by synthetic tools with high-spatiotemporal resolution could, therefore, enable a deepened understanding of developmental processes and open new opportunities in tissue engineering. Here, we describe the first red/far-red light-triggered gene switch for mammalian cells for achieving gene expression control in time and space. We show that the system can reversibly be toggled between stable on- and off-states using short light pulses at 660 or 740 nm. Red light-induced gene expression was shown to correlate with the applied photon number and was compatible with different mammalian cell lines, including human primary cells. The light-induced expression kinetics were quantitatively analyzed by a mathematical model. We apply the system for the spatially controlled engineering of angiogenesis in chicken embryos. The system's performance combined with cell- and tissue-compatible regulating red light will enable unprecedented spatiotemporally controlled molecular interventions in mammalian cells, tissues and organisms." @default.
• W2169090274 created "2016-06-24" @default.
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• W2169090274 date "2013-01-25" @default.
• W2169090274 modified "2023-10-16" @default.
• W2169090274 title "A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells" @default.
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• W2169090274 doi "https://doi.org/10.1093/nar/gkt002" @default.
• W2169090274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3627562" @default.
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